Patent US2401434A successfully refreshed from Google Patents.
US3972995A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dosage form
Assignee: Wyeth LLC
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Filing: 1975-04-14
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Granted: 1976-08-03
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Expires: 1995-04-14
Abstract
Abstract The disclosure is directed to dosage forms for buccal administration of a drug and are directly applicable to the interior surfaces of the mouth. The dosage form is comprised of a support member, which is water insoluble, waterproof and flexible, a moisture activated, adhesive precursor applied to one surface of the support member and an active ingredient applied to the central portion of the support member either directly or dispersed in a matrix. In one embodiment, a recess is provided in the support member to receive the active ingredient. When the dosage form is applied directly to the interior surface of the mouth, contact with saliva activates the adhesive and causes the support member to adhere to the interior surface of the mouth, thereby exposing the active ingredient to a limited area of the oral mucosa while isolating the active ingredient from the remainder of the oral environment.
Inventors
- 👤 Andrew G. Tsuk
- 👤 Frederick H. Martin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:17
CPC Classifications
A; A61; A61M; A61M31/00; A61M31/002; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/006; A61K9/70
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
115 words
A buccal dosage form for buccal administration of a buccally effective medicament comprising: a. a preshaped, planar, water-insoluble support member comprised of an inert flexible film; b. a concave recess defined in a portion of one surface of said support member further defining a planar margin of the support member surface surrounding the concave recess, c. a moisture-activated adhesive precurser comprised of a hydrocolloid admixed with polyvinylpyrrolidone applied to at least the planar margin of the support member surface surrounding the concave recess. d. a medicament effective buccally supported in said concave recess, the top surface of said medicament being below or coplanar with the margin of said support member surface surrounding the concave recess.
Claim 2
Dependent Claim
115 words
A buccal dosage form for buccal administration of a buccally effective medicament comprising: a. a preshaped, planar, water-insoluble support member comprised of an inert flexible film; b. a concave recess defined in a portion of one surface of said support member further defining a planar margin of the support member surface surrounding the concave recess, c. a moisture-activated adhesive precurser comprised of a hydrocolloid admixed with polyvinylpyrrolidone applied to at least the planar margin of the support member surface surrounding the concave recess. d. a medicament effective buccally supported in said concave recess, the top surface of said medicament being below or coplanar with the margin of said support member surface surrounding the concave recess.
Claim 3
Dependent Claim
155 words
A buccal dosage form for buccal administration of a buccally effective medicament comprising: a. a preshaped, planar water-insoluble support member comprised of a film of ethylcellulose plasticized with castor oil; b. a concave recess defined in a portion of one surface of said support member further defining a planar margin of the surface of said support member surrounding the concave recess, c. a moisture-impervious layer comprised of an isobutyleneisoprene copolymer applied to the side of said support member wherein the concave recess is defined; d. a moisture activated adhesive precursor comprised of finely powdered Karaya gum in a viscous solution of polyvinylpyrrolidone in polyethylene glycol applied to at least the planar margin of the support member surface surrounding the concave recess; e. a medicament effective buccally supported in said concave recess, the top surface of said medicament being below or coplanar with the margin of the surface of said support member surrounding the concave surface.
Claim 4
Dependent Claim
155 words
A buccal dosage form for buccal administration of a buccally effective medicament comprising: a. a preshaped, planar water-insoluble support member comprised of a film of ethylcellulose plasticized with castor oil; b. a concave recess defined in a portion of one surface of said support member further defining a planar margin of the surface of said support member surrounding the concave recess, c. a moisture-impervious layer comprised of an isobutyleneisoprene copolymer applied to the side of said support member wherein the concave recess is defined; d. a moisture activated adhesive precursor comprised of finely powdered Karaya gum in a viscous solution of polyvinylpyrrolidone in polyethylene glycol applied to at least the planar margin of the support member surface surrounding the concave recess; e. a medicament effective buccally supported in said concave recess, the top surface of said medicament being below or coplanar with the margin of the surface of said support member surrounding the concave surface.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-08-03 | 1980-02-02 | 1980-08-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-08-03 | 1984-02-02 | 1984-08-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-08-03 | 1988-02-02 | 1988-08-03 | $7700.00 | Window Closed / Lapsed |