Patent EP0428998A1 successfully refreshed from Google Patents.
US4764377A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Intra-pocket drug delivery devices for treatment of periodontal diseases
Assignee: ADA Forsyth Institute Inc
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Filing: 1987-02-13
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Granted: 1988-08-16
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Expires: 2007-02-13
Abstract
Abstract Therapeutic agent delivery devices and methods for using them in treatment of dental disease are disclosed. In the treatment of periodontal disease, a therapeutic agent such as tetracycline mixed in a polymeric matrix such as ethylene vinyl acetate copolymer is packed into the area to be treated and kept in place for a suitable time, during which the therapeutic agent diffuses out of the polymeric matrix, providing continuous therapy for the treatment site.
Inventors
- 👤 J. Max Goodson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:16
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0063; A61K6/00; A61K6/30; A61C; A61C19/00; A61C19/06; A61C19/063
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
137 words
A therapeutic agent delivery device suitable for continuously delivering a pharmacologically-effective level of therapeutic agent to the site of a periodontal infection within a periodontal pocket, comprising a therapeutic agent selected from the group consisting of immune-suppressive agents, immune-stimulatory agents, dentinal desensitizers, odor masking agents, immune reagents, antiinflammatory agents, antibacterials, anesthetics, nutritional agents, antioxidants, lipopolysaccharide complexing agents and peroxides; and a biocompatible polymeric material having a glass transition temperature of less than 37° C., said polymeric material containing said therapeutic material impregnated therein and being permeable to said therapeutic material, the combination of said therapeutic agent and said polymeric material being in the form of a fiber having a diameter of about 0.1 to 1 mm, and the polymeric material is a polymer selected from the group consisting of collagen, glycolic acid polymers, methacrylate polymers, and polylactides.
Claim 2
Dependent Claim
137 words
A therapeutic agent delivery device suitable for continuously delivering a pharmacologically-effective level of therapeutic agent to the site of a periodontal infection within a periodontal pocket, comprising a therapeutic agent selected from the group consisting of immune-suppressive agents, immune-stimulatory agents, dentinal desensitizers, odor masking agents, immune reagents, antiinflammatory agents, antibacterials, anesthetics, nutritional agents, antioxidants, lipopolysaccharide complexing agents and peroxides; and a biocompatible polymeric material having a glass transition temperature of less than 37° C., said polymeric material containing said therapeutic material impregnated therein and being permeable to said therapeutic material, the combination of said therapeutic agent and said polymeric material being in the form of a fiber having a diameter of about 0.1 to 1 mm, and the polymeric material is a polymer selected from the group consisting of collagen, glycolic acid polymers, methacrylate polymers, and polylactides.
Claim 3
Dependent Claim
18 words
The therapeutic agent delivery device of claim 1 wherein the fiber has a diameter of about 0.5 mm.
Claim 4
Dependent Claim
23 words
The therapeutic agent delivery device of claim 2 wherein said polymeric material contains 10 to 50 percent by weight of said therapeutic material.
Claim 5
Dependent Claim
21 words
The therapeutic agent delivery device of claim 2 wherein said polymeric material for a glass transition temperature less than 32° C.
Claim 6
Dependent Claim
21 words
The therapeutic agent delivery device of claim 2 wherein said polymeric material for a glass transition temperature less than 28° C.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-08-16 | 1992-02-15 | 1992-08-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-08-16 | 1996-02-15 | 1996-08-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-08-16 | 2000-02-15 | 2000-08-16 | $7700.00 | Window Closed / Lapsed |