US4024871A
Expired / Lapsed
US
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Antimicrobial sutures
Assignee: Ethicon Inc
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Filing: 1975-07-23
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Granted: 1977-05-24
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Expires: 1995-07-23
Abstract
Abstract Multifilament suture strands are impregnated with an antimicrobial agent and top coated with a segmented polyurethane polymer. The coated sutures possess antimicrobial properties which are retained during use over extended periods of time.
Inventors
- 👤 Martin Stephenson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:52
CPC Classifications
A; A61; A61L; A61L17/00; A61L17/005; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/406
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
38 words
A surgical suture exhibiting antimicrobial properties comprising a multifilament suture strand impregnated with an antimicrobial agent and its entire surface coated with a substantially continuous layer of a segmented polyurethane, said polyurethane initially being free of antimicrobial agent.
Claim 2
Dependent Claim
38 words
A surgical suture exhibiting antimicrobial properties comprising a multifilament suture strand impregnated with an antimicrobial agent and its entire surface coated with a substantially continuous layer of a segmented polyurethane, said polyurethane initially being free of antimicrobial agent.
Claim 3
Dependent Claim
25 words
A suture of claim 1 wherein the antimicrobial agent is soluble in a solvent which is compatible with both the antimicrobial agent and the suture.
Claim 4
Dependent Claim
14 words
A suture of claim 2 wherein the antimicrobial agent is water or alcohol soluble.
Claim 5
Dependent Claim
14 words
A suture of claim 1 wherein the antimicrobial agent is anionic, cationic, or nonionic.
Claim 6
Dependent Claim
47 words
A suture of claim 1 wherein the antimicrobial agent is selected from the group consisting of tetracycline hydrochloride, neomycin sulfate, chloramphenicol, streptomycin sulfate, potassium penicillin, polymixin B sulfate, oxytetracycline hydrochloride, gentamycin sulfate, sodium cephalothin, nitrofurazone, rifamycin, benzethonium chloride, sodium oxacillin, dihydrostreptomycin sulfate, disodium carbenicillin, and sodium furadantin.
Claim 7
Dependent Claim
25 words
A suture of claim 1 wherein the concentration of antimicrobial agent impregnating the suture is from about 0.2 to 5 percent by weight of suture.
Claim 8
Dependent Claim
16 words
A suture of claim 1 wherein the multifilament suture is a braided, twisted, or covered suture.
Claim 9
Dependent Claim
18 words
A suture of claim 1 wherein the multifilament suture is a silk, cotton, linen, polyolefin or polyester suture.
Claim 10
Dependent Claim
24 words
A suture of claim 1 wherein the layer of segmented polyurethane comprises from about 5 to 10 percent of the weight of the suture.
Claim 11
Dependent Claim
14 words
A suture of claim 1 wherein the segmented polyurethane is a spandex type polymer.
Claim 12
Dependent Claim
55 words
A suture of claim 10 wherein the segmented polyurethane is comprised of soft segments derived from polymers having a melting point below about 50° C. and a molecular weight above about 600, and hard segments derived from polymers having a melting point above about 200° C. and a molecular weight in the fiber forming range.
Claim 13
Dependent Claim
76 words
A suture of claim 11 wherein the segmented polyurethane is derived from the reaction of a polytetramethylene ether glycol of a molecular weight about 1800 with p,p'-methylenediphenyl diisocyanate in a ratio of about 1.7 moles of diisocyanate per mole of polyether glycol, to form a prepolymer and the prepolymer is extended with about a stoichiometric amount of a mixture of about 80 mole percent ethylenediamine and 20 mole percent 1,3-cyclohexylene-diamine and about 7 mole percent diethylamine.
Claim 14
Independent Claim
74 words
A method for preparing an antimicrobial suture comprising the steps of a. impregnating the suture with a solution of an antimicrobial agent; b. coating the entire surface of the impregnated suture with a solution of a segmented polyurethane polymer in a solvent, said solution being substantially free of antimicrobial agent; and c. drying the coated suture to remove the solvent and provide the impregnated suture with a substantially continuous covering of segmented polyurethane polymer.
Claim 15
Independent Claim
74 words
A method for preparing an antimicrobial suture comprising the steps of a. impregnating the suture with a solution of an antimicrobial agent; b. coating the entire surface of the impregnated suture with a solution of a segmented polyurethane polymer in a solvent, said solution being substantially free of antimicrobial agent; and c. drying the coated suture to remove the solvent and provide the impregnated suture with a substantially continuous covering of segmented polyurethane polymer.
Claim 16
Dependent Claim
21 words
A method of claim 13 wherein the impregnated suture contains from 0.2 to about 5 percent by weight of antimicrobial agent.
Claim 17
Dependent Claim
22 words
A method of claim 13 wherein the coated suture contains from about 5 to 10 percent by weight of segmented polyurethane polymer.
Claim 18
Dependent Claim
18 words
A method of claim 13 wherein the impregnated suture is dried prior to coating with said polyurethane polymer.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-23 | 1980-11-22 | 1981-05-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-23 | 1984-11-22 | 1985-05-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-23 | 1988-11-22 | 1989-05-24 | $7700.00 | Window Closed / Lapsed |