Patent US3826963A successfully refreshed from Google Patents.
US4226848A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and preparation for administration to the mucosa of the oral or nasal cavity
Assignee: Teijin Ltd
•
Filing: 1979-03-02
•
Granted: 1980-10-07
•
Expires: 1999-03-02
Abstract
Abstract A method for administering a medicament which comprises adhering to the mucosa of the oral or nasal cavity a pharmaceutical preparation comprising (a) a water-swellable and mucosa-adhesive polymeric matrix comprising about 50 to about 95% by weight of a cellulose ether and about 50 to about 5% by weight of a homo- or copolymer of acrylic acid or a pharmaceutically acceptable salt thereof, and (b) dispersed therein, pharmaceutically effective amount of the medicament, said preparation releasing continuously the medicament at a controlled rate; and causing the released medicament to be absorbed through the mucosa or enterally; said mucosa-adhesive preparation; and process for said preparation.
Inventors
- 👤 Tsuneji Nagai
- 👤 Yoshiharu Machida
- 👤 Yoshiki Suzuki
- 👤 Hiroshi Ikura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:26
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0043; A61K9/0053; A61K9/006; A61K47/00; A61K47/30; A61K47/32; A61K47/36; A61K47/38
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
95 words
A method for administering a medicament which comprises adhering to the mucosa of the nasal cavity a pharmaceutical preparation comprising (a) a water-swellable and mucosa-adhesive polymeric matrix comprising about 50 to about 95% by weight of a cellulose ether and about 50 to about 5% by weight of a homo- or copolymer of acrylic acid or a pharmaceutically acceptable salt thereof, and (b) dispersed therein, a pharmaceutically effective amount of the medicament, said preparation releasing continuously the medicament at a controlled rate; and causing the released medicament to be absorbed through the mucosa or enterally.
Claim 2
Independent Claim
95 words
A method for administering a medicament which comprises adhering to the mucosa of the nasal cavity a pharmaceutical preparation comprising (a) a water-swellable and mucosa-adhesive polymeric matrix comprising about 50 to about 95% by weight of a cellulose ether and about 50 to about 5% by weight of a homo- or copolymer of acrylic acid or a pharmaceutically acceptable salt thereof, and (b) dispersed therein, a pharmaceutically effective amount of the medicament, said preparation releasing continuously the medicament at a controlled rate; and causing the released medicament to be absorbed through the mucosa or enterally.
Claim 3
Dependent Claim
42 words
The method of claim 1 wherein said polymeric matrix comprises about 65 to about 90% by weight of the cellulose ether and about 35 to about 10% by weight of the homo- or copolymer of acrylic acid or its pharmaceutically acceptable salt.
Claim 4
Dependent Claim
20 words
The method of claim 1 wherein the cellulose ether is a lower alkyl or hydroxy lower alkyl ether of cellulose.
Claim 5
Dependent Claim
25 words
The method of claim 1 wherein the cellulose ether is selected from the group consisting of methyl cellulose, hydroxyethyl cellulose, hydroxypropylmethyl cellulose and hydroxypropyl cellulose.
Claim 6
Dependent Claim
32 words
The method of claim 1 wherein the cellulose ether is hydroxypropyl cellulose having a viscosity, determined at 20° C. for a 2% by weight aqueous solution thereof, of 3 to 10,000 centipoises.
Claim 7
Dependent Claim
54 words
The method of claim 1 wherein the polymer of acrylic acid has a viscosity of 360 to 165,000 centipoises when it is measured at 25.0±5° C. for an aqueous solution of the sodium salt of the polymer having a pH of 7 to 7.5 and a concentration of 0.2% by weight as free polymer.
Claim 8
Dependent Claim
17 words
The method of claim 1 wherein the pharmaceutical preparation further comprises an excipient dispersed in the matrix.
Claim 9
Dependent Claim
58 words
The method of claim 1 wherein the medicament is selected from the group consisting of analgesic and anti-inflammatory agents, anti-inflammatory enzyme preparations, anti-inflammatory steroids, antihistamines, antibiotics, antibacterial agents, chemotherapeutic agents, local anaesthesias, cardiac tonics, vasodilators, antitussive and expectorants, oral antiseptics, enzyme proteins, hypoglycemic agents, hemostats, hormones, hypotensive agents, sedatives or tranquilizers, anti-tumor agents, gastro intestinal drugs and antacids.
Claim 10
Dependent Claim
22 words
The method of claim 1 wherein the pharmaceutical preparation is in the form of tablets, granules, fine granules, powders and dental cone.
References Cited (Backward Citations)
US2997399A
Cited
US3511791A
Cited
US3440065A
Cited
US3833518A
Cited
US3868259A
Cited
US3868432A
Cited
US4059686A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-10-07 | 1984-04-07 | 1984-10-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-10-07 | 1988-04-07 | 1988-10-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-10-07 | 1992-04-07 | 1992-10-07 | $7700.00 | Window Closed / Lapsed |