US4524065A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for the prevention and treatment of scars with enzymes
Assignee: BIO-SPECIFICS NV A NETHERLANDS ANTILLES CORP
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Filing: 1983-08-04
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Granted: 1985-06-18
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Expires: 2003-08-04
Abstract
Abstract A method for the prevention of and for the dissolution of mammalian cicatrices such as acne scars, keloids and other hypertrophic scars comprising intralesional injection of effective amounts of a pharmacologically suitable solution of the enzyme collagenase, by itself, and collagenase in combination with the enzyme hyaluronidase.
Inventors
- 👤 Sheldon R. Pinnell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:10
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/43; A61K38/46; A61K38/48; A61K38/4886; A61K38/51
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
22 words
A method for the dissolution of mammalian cicatrices which comprises administering an effective amount of the enzyme collagenase directly into the lesion.
Claim 2
Independent Claim
22 words
A method for the dissolution of mammalian cicatrices which comprises administering an effective amount of the enzyme collagenase directly into the lesion.
Claim 3
Dependent Claim
27 words
The method of claim 1 wherein the collagenase is a culture of a special strain of clostridium histolyticum chromatographically purified to be free of detectable protease activity.
Claim 4
Dependent Claim
18 words
The method of claim 1 wherein the collagenase is administered in the range of 50 to 500 units.
Claim 5
Dependent Claim
20 words
The method of claim 1 wherein the collagenase is administered in a series of intralesional injections at spaced time intervals.
Claim 6
Dependent Claim
11 words
The method of claim 1 wherein the cicatrix is a keloid.
Claim 7
Dependent Claim
12 words
The method of claim 1 wherein the cicatrix is a hypertrophic scar.
Claim 8
Dependent Claim
12 words
The method of claim 1 wherein the cicatrix is an acne scar.
Claim 9
Dependent Claim
12 words
The method of claim 1 wherein the cicatrix is a depressed scar.
Claim 10
Dependent Claim
11 words
The method of claim 1 wherein the cicatrix is a wrinkle.
Claim 11
Dependent Claim
10 words
The method of claim 1 wherein the cicatrix is cellulite.
Claim 12
Dependent Claim
11 words
The method of claim 1 wherein the cicatrix is neoplastic fibrosis.
Claim 13
Independent Claim
32 words
A method for the dissolution of mammalian cicatrices which comprises administering an effective amount of the enzyme collagenase in combination with an effective amount of the enzyme hyaluronidase directly into the lesion.
Claim 14
Independent Claim
32 words
A method for the dissolution of mammalian cicatrices which comprises administering an effective amount of the enzyme collagenase in combination with an effective amount of the enzyme hyaluronidase directly into the lesion.
Claim 15
Dependent Claim
30 words
The method of claim 12 wherein the collagenase is administered in the range of 50 to 500 units in combination with hyaluronidase in the range of 25 to 250 units.
Claim 16
Dependent Claim
11 words
The method of claim 12 wherein the cicatrix is a keloid.
Claim 17
Dependent Claim
12 words
The method of claim 12 wherein the cicatrix is a hypertrophic scar.
Claim 18
Dependent Claim
12 words
The method of claim 12 wherein the cicatrix is an acne scar.
Claim 19
Dependent Claim
12 words
The method of claim 12 wherein the cicatrix is a depressed scar.
Claim 20
Dependent Claim
11 words
The method of claim 12 wherein the cicatrix is a wrinkle.
Claim 21
Dependent Claim
10 words
The method of claim 12 wherein the cicatrix is cellulite.
Claim 22
Dependent Claim
11 words
The method of claim 12 wherein the cicatrix is neoplastic fibrosis.
Claim 23
Independent Claim
27 words
A method for the prevention of mammalian cicatrices which comprises administering an effective amount of the enzyme collagenase directly into the affected area during the healing process.
Claim 24
Independent Claim
27 words
A method for the prevention of mammalian cicatrices which comprises administering an effective amount of the enzyme collagenase directly into the affected area during the healing process.
Claim 25
Dependent Claim
18 words
The method of claim 21 wherein the collagenase is administered in the range of 50 to 500 units.
Claim 26
Independent Claim
37 words
A method for the prevention of mammalian cicatrices which comprises administering an effective amount of the enzyme collagenase in combination with an effective amount of the enzyme hyaluronidase directly into the affected area during the healing process.
Claim 27
Independent Claim
37 words
A method for the prevention of mammalian cicatrices which comprises administering an effective amount of the enzyme collagenase in combination with an effective amount of the enzyme hyaluronidase directly into the affected area during the healing process.
Claim 28
Dependent Claim
30 words
The method of claim 23 wherein the collagenase is administered in the range of 50 to 500 units in combination with hyaluronidase in the range of 25 to 250 units.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-06-17 | 1988-12-17 | 1989-06-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-06-17 | 1992-12-17 | 1993-06-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-06-17 | 1996-12-17 | 1997-06-18 | $7700.00 | Window Closed / Lapsed |