US4174389A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Ophthalmic use of collagenase
Assignee: Individual
•
Filing: 1977-05-13
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Granted: 1979-11-13
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Expires: 1997-05-13
Abstract
Abstract A method for the selective lysis of collagen fibrils located in the ocular region of a mammal comprising injecting into said ocular region an effective amount of a pharmacologically suitable solution comprising collagenase; and contacting said fibrils with said solution for a period of time sufficient to lyse said fibrils.
Inventors
- 👤 Louise A. Cope
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 20:55
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/43; A61K38/46; A61K38/48; A61K38/4886
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
82 words
A method for the selective lysis of collagen fibrils located in the vitreous of the ocular region of a mammal comprising: injecting intravitreally a small but effective amount of a pharmacologically suitable solution comprising a concentrated amount of collagenase; contacting said fibrils with said solution; flushing the intravitreal region by injecting an effective amount of an inactivator of collagenase solution; and removing said collagenase solution from said intravitreal region before said solution damages other ocular structures not intended to be affected thereby.
Claim 2
Independent Claim
82 words
A method for the selective lysis of collagen fibrils located in the vitreous of the ocular region of a mammal comprising: injecting intravitreally a small but effective amount of a pharmacologically suitable solution comprising a concentrated amount of collagenase; contacting said fibrils with said solution; flushing the intravitreal region by injecting an effective amount of an inactivator of collagenase solution; and removing said collagenase solution from said intravitreal region before said solution damages other ocular structures not intended to be affected thereby.
Claim 3
Dependent Claim
24 words
The method of claim 1 wherein said steps of injecting an inactivator of collagenase solution and removing said collagenase solution are performed substantially simultaneously.
Claim 4
Independent Claim
117 words
A method for the selective lysis of collagen fibrils located in the vitreous of the ocular region of a mammal comprising: preparing a pharmacologically suitable solution comprising collagenase produced from the bacterium Clostridium histolyticum by addmixing a concentrated amount of said collagenase with a solution having a pH of about 7.40 and containing a sufficient amount of calcium ions to activate said collagenase; injecting intravitreally a small but effective amount of said pharmacologically suitable solution comprising a concentrated amount of collagenase; flushing the intravitreal region by injecting an effective amount of an inactivator of collagenase solution; and removing said collagenase from said intravitreal region before said solution damages other ocular structures not intended to be affected thereby.
Claim 5
Independent Claim
117 words
A method for the selective lysis of collagen fibrils located in the vitreous of the ocular region of a mammal comprising: preparing a pharmacologically suitable solution comprising collagenase produced from the bacterium Clostridium histolyticum by addmixing a concentrated amount of said collagenase with a solution having a pH of about 7.40 and containing a sufficient amount of calcium ions to activate said collagenase; injecting intravitreally a small but effective amount of said pharmacologically suitable solution comprising a concentrated amount of collagenase; flushing the intravitreal region by injecting an effective amount of an inactivator of collagenase solution; and removing said collagenase from said intravitreal region before said solution damages other ocular structures not intended to be affected thereby.
Claim 6
Dependent Claim
24 words
The method of claim 3 wherein said steps of injecting an inactivator of collagenase solution and removing said collagenase solution are performed substantially simultaneously.
Claim 7
Independent Claim
71 words
A method for the selective lysis of collagen fibrils located in the anterior chamber of the ocular region of a mammal comprising: injecting into said anterior chamber a small but effective amount of a pharmacologically suitable solution comprising a concentrated amount of collagenase; contacting said fibrils with said solution; and removing said collagenase solution from said anterior chamber before said solution damages other ocular structures not intended to be affected thereby.
Claim 8
Independent Claim
71 words
A method for the selective lysis of collagen fibrils located in the anterior chamber of the ocular region of a mammal comprising: injecting into said anterior chamber a small but effective amount of a pharmacologically suitable solution comprising a concentrated amount of collagenase; contacting said fibrils with said solution; and removing said collagenase solution from said anterior chamber before said solution damages other ocular structures not intended to be affected thereby.
Claim 9
Dependent Claim
15 words
The method of claim 5 wherein said collagenase is naturally removed from said anterior chamber.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-11-12 | 1983-05-14 | 1983-11-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-11-12 | 1987-05-14 | 1987-11-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-11-12 | 1991-05-14 | 1991-11-13 | $7700.00 | Window Closed / Lapsed |