US5100429A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Endovascular stent and delivery system
Assignee: Medtronic Vascular Inc
•
Filing: 1989-10-20
•
Granted: 1992-03-31
•
Expires: 2009-10-20
Abstract
Abstract An uncured or partially cured, collagen-based material is delivered to a selected site in a blood vessel and is crosslinked in the blood vessel by laser energy or other suitable energy to form an endovascular stent. The collagen-based material can be delivered to the blood vessel as a coating on an inflatable balloon mounted on the distal end of a catheter. The collagen-based material can also be delivered to the blood vessel in liquid form and forced through a porous balloon to form a tubular configuration. The collagen-based material is preferably crosslinked by laser radiation carried through an optical fiber to a diffusing tip located within the balloon. In another embodiment, an endovascular stent is formed by rolling a flexible sheet of biologically-compatible material onto an outside surface of an inflatable balloon. A crosslinkable collagen-based adhesive is used to adhere overlapping portions of the sheet together in the blood vessel and can be used to attach the stent to an inside surface of the blood vessel. The collagen-based adhesive is crosslinked in the blood vessel by application of laser energy or other suitable energy. A photodegradable adhesive can be used on an inside surface of the stent to releasably attach the stent to the inflatable balloon.
Inventors
- 👤 Edward L. Sinofsky
- 👤 Gary L. Boseck
- 👤 Edward I. McNamara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:31
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/82; A61F2/92; A61F2/95; A61F2/958; A61B; A61B17/00; A61B17/00491; A61B2017/005; A61B2017/00513; A61B2017/00517; A61F2/02; A61F2/04; A61F2/06; A61F2/07; A61F2220/00; A61F2220/0008; A61F2220/0025; A61F2220/005; A61M; A61M25/00; A61M25/10; A61M25/1011; A61M2025/1013; Y; Y10; Y10S; Y10S128/00; Y10S128/08
Claims Analysis
Total Claims: 47
Claim 1
Independent Claim
116 words
A method for treating a selected region of a blood vessel, comprising the steps of: applying a crosslinkable adhesive material to one side of a flexible sheet of biologically-compatible material; rolling the sheet of biologically-compatible material so that portions of the sheet overlap to form a generally tubular body, said tubular body having said crosslinkable adhesive material between overlapping portions of the sheet; delivering the tubular body to the selected region of the blood vessel; and applying energy to the tubular body at the selected region of the blood vessel so as to crosslink the adhesive material and cause overlapping portions of the sheet to adhere together to thereby form a stent in the blood vessel.
Claim 2
Independent Claim
116 words
A method for treating a selected region of a blood vessel, comprising the steps of: applying a crosslinkable adhesive material to one side of a flexible sheet of biologically-compatible material; rolling the sheet of biologically-compatible material so that portions of the sheet overlap to form a generally tubular body, said tubular body having said crosslinkable adhesive material between overlapping portions of the sheet; delivering the tubular body to the selected region of the blood vessel; and applying energy to the tubular body at the selected region of the blood vessel so as to crosslink the adhesive material and cause overlapping portions of the sheet to adhere together to thereby form a stent in the blood vessel.
Claim 3
Dependent Claim
22 words
A method as defined in claim 1 wherein the step of applying a crosslinkable adhesive material includes applying a crosslinkable collagen-based material.
Claim 4
Dependent Claim
39 words
A method as defined in claim 1 wherein the step of rolling the sheet of biologically-compatible material includes rolling the sheet onto an outer surface of an inflatable balloon located at or near the distal end of a catheter.
Claim 5
Dependent Claim
32 words
A method as defined in claim 3 wherein the step of delivering the tubular body includes advancing the catheter through the blood vessel until the balloon is positioned at the selected region.
Claim 6
Dependent Claim
39 words
A method as defined in claim 4 further including the step of inflating the balloon to thereby increase the diameter of the tubular body and urge the tubular body into contact with an inside surface of the blood vessel.
Claim 7
Dependent Claim
21 words
A method as defined in claim 1 wherein the step of applying energy includes applying light energy to the tubular body.
Claim 8
Dependent Claim
22 words
A method as defined in claim 1 wherein the step of applying energy includes applying diffused laser energy to the tubular body.
Claim 9
Dependent Claim
53 words
A method as defined in claim 3 further including the step of applying a photodegradable adhesive to the other side of the sheet of biologically-compatible material prior to the step of rolling the sheet onto an inflatable balloon so that said tubular body is adhered to said inflatable balloon by said photodegradable adhesive.
Claim 10
Dependent Claim
48 words
A method as defined in claim 8 wherein the step of applying energy to the tubular body includes applying energy i a first wavelength range selected to degrade said photodegradable adhesive and release said tubular body from said inflatable balloon in the selected region of the blood vessel.
Claim 11
Dependent Claim
69 words
A method as defined in claim 9 wherein said photodegradable adhesive includes a fluorescent material that is stimulated by energy in said first wavelength range to emit energy in a second wavelength range required for crosslinking of said crosslinkable adhesive material so that said photodegradable adhesive is degraded by energy in said first wavelength range and said crosslinkable adhesive material is crosslinked by energy emitted by said fluorescent material.
Claim 12
Dependent Claim
32 words
A method as define din claim 2 wherein said collagen-based material comprises a collagen containing riboflavin and the step of applying energy includes applying energy int he visible or near-ultraviolet wavelength range.
Claim 13
Dependent Claim
14 words
A method as defined in claim 8 wherein said photodegradable adhesive comprises a polyamide.
Claim 14
Dependent Claim
13 words
A method as defined in claim 8 wherein said photodegradable adhesive comprises nitrocellulose.
Claim 15
Dependent Claim
15 words
A method as defined in claim 10 wherein said fluorescent material comprises a laser dye.
Claim 16
Dependent Claim
14 words
A method as defined in claim 1 wherein said sheet has a continuous surface.
Claim 17
Dependent Claim
17 words
A method as defined in claim 1 wherein said sheet is patterned with a plurality of openings.
Claim 18
Dependent Claim
44 words
A method as defined in claim 1 wherein said crosslinkable adhesive material is applied to an outside surface of said tubular body and wherein the step of applying energy to the tubular body causes the tubular body to be attached to the blood vessel.
Claim 19
Dependent Claim
148 words
A combination of a stent and an apparatus for placing a stent in a selected region of a blood vessel, comprising: a flexible, elongated tube having an inflatable balloon at or near its distal end; a generally tubular body comprising a sheet of biologically-compatible material rolled onto said balloon so that portions of the sheet overlap, said tubular body having a crosslinkable adhesive material between overlapping portions of the sheet, said tubular body being releaseably adhered to the outside surface of said balloon; means for inflating said balloon to thereby urge said tubular body into contact with an inside surface of said blood vessel; and means for applying energy to the tubular body at the selected region of the blood vessel with said balloon inflated so as to crosslink the crosslinkable adhesive material and cause overlapping portions of the sheet to adhere together to thereby form a stent.
Claim 20
Dependent Claim
148 words
A combination of a stent and an apparatus for placing a stent in a selected region of a blood vessel, comprising: a flexible, elongated tube having an inflatable balloon at or near its distal end; a generally tubular body comprising a sheet of biologically-compatible material rolled onto said balloon so that portions of the sheet overlap, said tubular body having a crosslinkable adhesive material between overlapping portions of the sheet, said tubular body being releaseably adhered to the outside surface of said balloon; means for inflating said balloon to thereby urge said tubular body into contact with an inside surface of said blood vessel; and means for applying energy to the tubular body at the selected region of the blood vessel with said balloon inflated so as to crosslink the crosslinkable adhesive material and cause overlapping portions of the sheet to adhere together to thereby form a stent.
Claim 21
Dependent Claim
13 words
Apparatus as defined in claim 18 wherein said biologically-compatible material comprises polylactic acid.
Claim 22
Dependent Claim
15 words
Apparatus as defined in claim 18 wherein said crosslinkable adhesive material comprises a collagen-based material.
Claim 23
Dependent Claim
15 words
Apparatus as defined in claim 20 wherein said collagen-based material comprises a collagen containing riboflavin.
Claim 24
Dependent Claim
18 words
Apparatus as defined in claim 18 wherein said means for applying energy includes mean for applying light energy.
Claim 25
Dependent Claim
19 words
Apparatus as defined in claim 18 wherein said means for applying energy includes means for applying diffused laser energy.
Claim 26
Dependent Claim
20 words
Apparatus as defined in claim 18 wherein said tubular body is releaseably adhered to said balloon with a photodegradable adhesive.
Claim 27
Dependent Claim
13 words
Apparatus as defined in claim 24 wherein said photodegradable adhesive comprises a polyamide.
Claim 28
Dependent Claim
12 words
Apparatus as defined in claim 24 wherein said photodegradable adhesive comprises nitrocellulose.
Claim 29
Dependent Claim
61 words
Apparatus as defined in claim 24 wherein said photodegradable adhesive includes a fluorescent material that is stimulated by energy in a first wavelength range selected to degrade said photodegradable adhesive and release said stent, said fluorescent material emitting energy in a second wavelength range required for crosslinking of said crosslinkable adhesive material when stimulated by energy in said first wavelength range.
Claim 30
Dependent Claim
41 words
Apparatus as defined in claim 18 wherein said tubular body has said crosslinkable adhesive material on an outside surface thereof and said means for applying energy to the tubular body causes the tubular body to be attached to the blood vessel.
Claim 31
Dependent Claim
13 words
Apparatus as defined in claim 18 wherein said sheet has a continuous surface.
Claim 32
Dependent Claim
16 words
Apparatus as defined in claim 18 wherein said sheet is patterned with a plurality of openings.
Claim 33
Dependent Claim
43 words
An endovascular stent in a selected region of a blood vessel comprising a tubular body formed as a rolled sheet of biologically-compatible material wherein portions of the sheet overlap, said tubular body having a crosslinked adhesive material between overlapping portions of the sheet.
Claim 34
Dependent Claim
43 words
An endovascular stent in a selected region of a blood vessel comprising a tubular body formed as a rolled sheet of biologically-compatible material wherein portions of the sheet overlap, said tubular body having a crosslinked adhesive material between overlapping portions of the sheet.
Claim 35
Dependent Claim
15 words
An endovascular stent as defined in claim 31 wherein said biologically-compatible material comprises a polymer.
Claim 36
Dependent Claim
16 words
An endovascular stent as defined in claim 31 wherein said biologically compatible material comprises polylactic acid.
Claim 37
Dependent Claim
17 words
An endovascular stent as defined in claim 31 wherein said crosslinked adhesive material comprises a collagen-based material.
Claim 38
Dependent Claim
17 words
An endovascular stent as defined in claim 34 wherein said collagen-based material comprises a collagen containing riboflavin.
Claim 39
Dependent Claim
21 words
An endovascular stent as defined in claim 31 further including a photodegradable adhesive on an inside surface of said tubular body.
Claim 40
Dependent Claim
15 words
An endovascular stent as defined in claim 36 wherein said photodegradable material comprises a polyamide.
Claim 41
Dependent Claim
14 words
An endovascular stent as defined in claim 36 wherein said photodegradable material comprises nitrocellulose.
Claim 42
Dependent Claim
63 words
An endovascular stent as defined in claim 36 wherein said photodegradable adhesive includes a fluorescent material that is stimulated by energy in a first wavelength range selected to degrade said photodegradable adhesive and release said stent, said fluorescent material emitting energy in a second wavelength range required for crosslinking of said crosslinkable adhesive material when stimulated by energy in said first wavelength range.
Claim 43
Dependent Claim
22 words
An endovascular stent as defined in claim 31 wherein said tubular body has said crosslinked adhesive material on an outside surface thereof.
Claim 44
Dependent Claim
15 words
An endovascular stent as defined in claim 31 wherein said sheet has a continuous surface.
Claim 45
Dependent Claim
18 words
An endovascular stent as defined in claim 31 wherein said sheet is patterned with a plurality of openings.
Claim 46
Dependent Claim
18 words
An endovascular stent as defined in claim 42 wherein said tubular configuration comprises a plurality of interconnected rings.
Claim 47
Dependent Claim
24 words
An endovascular stent as defined in claim 43 wherein interconnected rings have different widths to provide variable flexibility along the length of the stent.
References Cited (Backward Citations)
US3173418A
Cited
US3563925A
Cited
US3625745A
Cited
US3808113A
Cited
US3949073A
Cited
US4060081A
Cited
US4390519A
Cited
US4319363A
Cited
US4641653A
Cited
US4378017A
Cited
US4403612A
Cited
US4597762A
Cited
US4553545A
Cited
US4417576A
Cited
US4485096A
Cited
US4423725A
Cited
US4578067A
Cited
US4704131A
Cited
US4445892A
Cited
US4773899A
Cited
US4478658A
Cited
US4503569A
Cited
US4695281A
Cited
US4589882A
Cited
US4642118A
Cited
US4605406A
Cited
US4553974A
Cited
US4799479A
Cited
US4577631A
Cited
US4732152A
Cited
US4763653A
Cited
US4708718A
Cited
US4923464A
Cited
US4733665A
Cited
US4733665B1
Cited
US4733665C2
Cited
US4740207A
Cited
US4878492A
Cited
US4877030A
Cited
WO1989012478A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-03-31 | 1995-09-30 | 1996-03-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-03-31 | 1999-09-30 | 2000-03-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-03-31 | 2003-09-30 | 2004-03-31 | $7700.00 | Window Closed / Lapsed |