US4789662A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for the treatment of periodontal pockets with a composition comprising collagen and an antiseptic or anti-inflammatory substance
Assignee: Pierre Fabre Medicament SA
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Filing: 1986-12-19
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Granted: 1988-12-06
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Expires: 2006-12-19
Abstract
Abstract The present invention relates to a composition consisting of an association of collagen with an antiseptic and/or antiinflammatory active principle, the process for its preparation and its use for the production of a pharmaceutical composition. The pharmaceutical composition according to the invention comprises collagen as the vehicle and at least one antiseptic and/or inflammatory substance as the active principle. Application to the topical treatment of periodontal complaints.
Inventors
- 👤 Genevieve Thomas-Leurquin
- 👤 Anne Gayot
- 👤 Pierre Poitou
- 👤 Serge Basquin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 18:33
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/30; A61K47/42; A61K31/00; A61K31/13; A61K31/155; A61K38/00; A61K38/16; A61K38/17; A61K38/39; A61K8/00; A61K8/18; A61K8/30; A61K8/64; A61K8/65; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0063; A61Q; A61Q11/00; Y; Y10; Y10S; Y10S128/00; Y10S128/08
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
59 words
The method of treating a patient having at least one periodontal pocket which comprises introducing into said pocket a pharmaceutical composition comprising collagen as the vehicle and at least one antiseptic or anti-inflammatory substance as the active principle and maintaining said pharmaceutical composition in said pocket until said collagen is absorbed therefrom, said composite being in a flexible form.
Claim 2
Independent Claim
59 words
The method of treating a patient having at least one periodontal pocket which comprises introducing into said pocket a pharmaceutical composition comprising collagen as the vehicle and at least one antiseptic or anti-inflammatory substance as the active principle and maintaining said pharmaceutical composition in said pocket until said collagen is absorbed therefrom, said composite being in a flexible form.
Claim 3
Dependent Claim
23 words
A method as claimed in claim 1, wherein the said active principle is selected from the group consisting of chlorhexidine and its salts.
Claim 4
Dependent Claim
23 words
The method of claim 2 wherein said active principle is selected from the group consisting of chlorhexidine diacetate, chlorhexidine digluconate and chlorhexidine dihydrochloride.
Claim 5
Dependent Claim
17 words
A method as claimed in claim 2, wherein the weight ratio collagen/chlorhexidine is betwene 1:1 and 3:1.
Claim 6
Dependent Claim
18 words
A method as claimed in claim 4 in which said composition is in the form of a film.
Claim 7
Dependent Claim
18 words
A method as claimed in claim 4, in which said composition is in the form of a lyophilizate.
Claim 8
Dependent Claim
18 words
A method as claimed in claim 4, in which said composition is in the form of an implant.
Claim 9
Dependent Claim
23 words
A method as claimed in claim 2, in which the active principle concentration is between 0.5 mg and 5 mg per unit dose.
Claim 10
Dependent Claim
19 words
A method as claimed in claim 2, wherein the collagen used is a non-decrosslinked native collagen of bovine origin.
Claim 11
Independent Claim
95 words
A method as claimed in 1 wherein said pharmaceutical composition is prepared by the following steps: (a) the collagen is solubilized in acetic acid until a solution with a collagen concentration of between 0.5 g and 5 per 100 g of solution is obtained; (b) the active principle is solubilized in distilled water until a solution with an active principle concentration of between 1 g and 2 g per 100 g of solution is obtained; and (c) the two solutions obtained after steps (a) and (b) are mixed together and the solvents are then removed.
References Cited (Backward Citations)
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US4291013A
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US4517173A
Cited
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Cited
GB2131293A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-12-06 | 1992-06-06 | 1992-12-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-12-06 | 1996-06-06 | 1996-12-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-12-06 | 2000-06-06 | 2000-12-06 | $7700.00 | Window Closed / Lapsed |