US4645668A
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Method for the prevention and treatment of scars with enzymes
Assignee: BIO-SPECIFICAS NV INDUSTRIAL PARK KAVEL 1 T/M 5 BRIEVENGAT CURACAO NETHERLANDS ANTILLES A NETHERLANDS ANTILLES CORP
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Filing: 1985-03-27
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Granted: 1987-02-24
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Expires: 2005-03-27
Abstract
Abstract The method for preventing and for treating mammalian cicatrices such as keloids, acne scars, hypertrophic scars, wrinkles, cellulite and neoplastic fibrosis which comprises intra-dermal injection of effective amounts of a pharmacologically suitable solution of the enzymes collagenase, elastase, papain, plasminogen activator, plasmin, mast cell protease or lysosomal hydrolase, individually, and one or more of such enzymes in combination with the enzyme hyaluronidase.
Inventors
- 👤 Sheldon R. Pinnell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:25
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/43; A61K38/46; A61K38/48; A61K38/4886; A61K38/51
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
38 words
A method for the dissolution of mammalian cicatrices which comprises administering an effective amount of an enzyme selected from the group consisting of elastase, papain, plasminogen activator, plasmin, mast cell protease and lysosomol hydrolase directly into the lesion.
Claim 2
Independent Claim
38 words
A method for the dissolution of mammalian cicatrices which comprises administering an effective amount of an enzyme selected from the group consisting of elastase, papain, plasminogen activator, plasmin, mast cell protease and lysosomol hydrolase directly into the lesion.
Claim 3
Dependent Claim
14 words
The method of claim 1 wherein the elastase is electrophoretically purified porcine pancreatic elastase.
Claim 4
Dependent Claim
18 words
The method of claim 1 wherein the elastase is human neutrophilic polymorphonuclear leukocyte elastase purified by affinity chromatography.
Claim 5
Dependent Claim
18 words
The method of claim 1 wherein the elastases is purified from the conditioned medium of thioglycollate-elicited mouse macrophages.
Claim 6
Dependent Claim
19 words
The method of claim 1 wherein the plasmin is bovine or human plasmin prepared by activating plasminogen with urokinase.
Claim 7
Dependent Claim
24 words
The method of claim 1 wherein the mast cell protease is the highly purified neutral extract from the media of cultured metastatic tumor cells.
Claim 8
Independent Claim
48 words
A method for the dissolution of mammalian cicatrices which comprises administering an effective amount of an enzyme selected from the group consisting of elastase, papain, plasminogen activator, plasmin, mast cell protease and lysosomal hydrolase in combination with an effective amount of the enzyme collagenase directly into the lesion.
Claim 9
Independent Claim
48 words
A method for the dissolution of mammalian cicatrices which comprises administering an effective amount of an enzyme selected from the group consisting of elastase, papain, plasminogen activator, plasmin, mast cell protease and lysosomal hydrolase in combination with an effective amount of the enzyme collagenase directly into the lesion.
Claim 10
Independent Claim
48 words
A method for the dissolution of mammalian cicatrices which comprises administering an effective amount of an enzyme selected from the group consisting of elastase, papain, plasminogen activator, plasmin, mast cell protease and lysosomal hydrolase in combination with an effective amount of the enzyme hyaluronidase directly into the lesion.
Claim 11
Independent Claim
48 words
A method for the dissolution of mammalian cicatrices which comprises administering an effective amount of an enzyme selected from the group consisting of elastase, papain, plasminogen activator, plasmin, mast cell protease and lysosomal hydrolase in combination with an effective amount of the enzyme hyaluronidase directly into the lesion.
Claim 12
Independent Claim
53 words
A method for the prevention of mammalian cicatrices which comprises administering an effective amount of an enzyme selected from the group consisting of elastase, papain, plasminogen activator, plasmin, mast cell protease and lysosomal hydrolase in combination with an effective amount of the enzyme collagenase directly into the affected area during the healing process.
Claim 13
Independent Claim
53 words
A method for the prevention of mammalian cicatrices which comprises administering an effective amount of an enzyme selected from the group consisting of elastase, papain, plasminogen activator, plasmin, mast cell protease and lysosomal hydrolase in combination with an effective amount of the enzyme collagenase directly into the affected area during the healing process.
Claim 14
Independent Claim
53 words
A method for the prevention of mammalian cicatrices which comprises administering an effective amount of an enzyme selected from the group consisting of elastase, papain, plasminogen activator, plasmin, mast cell protease and lysosomal hydrolase in combination with an effective amount of the enzyme hyaluronidase directly into the affected area during the healing process.
Claim 15
Independent Claim
53 words
A method for the prevention of mammalian cicatrices which comprises administering an effective amount of an enzyme selected from the group consisting of elastase, papain, plasminogen activator, plasmin, mast cell protease and lysosomal hydrolase in combination with an effective amount of the enzyme hyaluronidase directly into the affected area during the healing process.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1990-02-23 | 1990-08-25 | 1991-02-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-02-23 | 1994-08-25 | 1995-02-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-02-23 | 1998-08-25 | 1999-02-24 | $7700.00 | Window Closed / Lapsed |