Patent US5108756A successfully refreshed from Google Patents.
US5108756A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dispensing devices powered by lyotropic liquid crystals
Assignee: Pfizer Inc
•
Filing: 1990-11-08
•
Granted: 1992-04-28
•
Expires: 2010-11-08
Abstract
Abstract This invention relates to devices useful for the controlled delivery of one or more beneficial agents to an environment of use. More specifically, this invention concerns such devices which are powered by lyotropic liquid crystals. This invention also relates to the controlled delivery of one or more beneficial agents to an aqueous environment of use through the use of such lyotropic liquid crystal powered dispensing devices. Also disclosed are methods for the controlled delivery of one or more beneficial agents to an aqueous environment of use which comprise administering to or otherwise placing the devices of this invention in the environment of use.
Inventors
- 👤 William J. Curatolo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 22:09
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0002; A61K9/0004
Claims Analysis
Total Claims: 52
Claim 1
Independent Claim
54 words
A dispensing device which comprises: (a) a mixture comprising a beneficial agent and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and (b) a coating containing a plurality of pores which coating surrounds the mixture.
Claim 2
Dependent Claim
54 words
A dispensing device which comprises: (a) a mixture comprising a beneficial agent and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and (b) a coating containing a plurality of pores which coating surrounds the mixture.
Claim 3
Dependent Claim
14 words
The dispensing device according to claim 1 wherein the beneficial agent is a drug.
Claim 4
Dependent Claim
15 words
The dispensing device according to claim 2 wherein the lyotropic liquid crystal is a phospholipid.
Claim 5
Dependent Claim
13 words
The dispensing device according to claim 3 wherein the coating comprises cellulose acetate.
Claim 6
Dependent Claim
25 words
The dispensing device according to claim 2 wherein the lyotropic liquid crystal is a salt of a fatty acid and the coating comprises cellulose acetate.
Claim 7
Dependent Claim
31 words
The dispensing device according to claim 2 wherein the lyotropic liquid crystal comprises a mixture of a phospholipid and a salt of a fatty acid and the coating comprises cellulose acetate.
Claim 8
Dependent Claim
16 words
The dispensing device according to claim 1 wherein the mixture additionally comprises an osmotically effective solute.
Claim 9
Dependent Claim
58 words
A dispensing device which comprises: (a) a mixture comprising a beneficial agents and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and (b) a coating which surrounds the mixture and which comprises a polymer and one or more porosigens.
Claim 10
Dependent Claim
58 words
A dispensing device which comprises: (a) a mixture comprising a beneficial agents and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and (b) a coating which surrounds the mixture and which comprises a polymer and one or more porosigens.
Claim 11
Dependent Claim
14 words
The dispensing device according to claim 8 wherein the beneficial agent is a drug.
Claim 12
Dependent Claim
15 words
The dispensing device according to claim 8 wherein the lyotropic liquid crystal is a phospholipid.
Claim 13
Dependent Claim
14 words
The dispensing device according to claim 10 wherein the coating polymer is cellulose acetate.
Claim 14
Dependent Claim
17 words
The dispensing device according to claim 11 wherein the porosigen is one or more water soluble polymers.
Claim 15
Dependent Claim
26 words
The dispensing device according to claim 12 wherein the water soluble polymer is selected from the group consisting of hydroxypropyl cellulose, polyethylene glycol and polyethylene oxide.
Claim 16
Dependent Claim
23 words
The dispensing device according to claim 11 wherein the porosigens are one or more water soluble polymers and one or more inorganic salts.
Claim 17
Dependent Claim
30 words
The dispensing device according to claim 11 wherein the porosigens are one or more water soluble polymers and one or more water soluble particulate organic compounds and the salts thereof.
Claim 18
Dependent Claim
24 words
The dispensing device according to claim 15 wherein the water soluble polymer is polyethylene glycol-600 and the water soluble particulate organic compound is sucrose.
Claim 19
Dependent Claim
28 words
The dispensing device according to claim 11 wherein the porosigen is one or more inorganic salts or one or more water soluble particulate organic compounds and salts thereof.
Claim 20
Dependent Claim
25 words
The dispensing device according to claim 9 wherein the lyotropic liquid crystal is a salt of a fatty acid and the coating comprises cellulose acetate.
Claim 21
Dependent Claim
31 words
The dispensing device according to claim 9 wherein the lyotropic liquid crystal comprises a mixture of a phospholipid and a salt of a fatty acid and the coating comprises cellulose acetate.
Claim 22
Dependent Claim
16 words
The dispensing device according to claim 8 wherein the mixture additionally comprises an osmotically effective solute.
Claim 23
Dependent Claim
101 words
A dispensing device which comprises: (a) a first layer comprising a mixture of a beneficial agent and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and (b) a second layer comprising a lyotropic liquid crystal which second layer is adjacent to the first layer and comprises an area in contact with the first layer; and (c) a coating containing at least one hole adjacent to the first layer which coating surrounds the first and second layers except for said area in contact.
Claim 24
Dependent Claim
101 words
A dispensing device which comprises: (a) a first layer comprising a mixture of a beneficial agent and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and (b) a second layer comprising a lyotropic liquid crystal which second layer is adjacent to the first layer and comprises an area in contact with the first layer; and (c) a coating containing at least one hole adjacent to the first layer which coating surrounds the first and second layers except for said area in contact.
Claim 25
Dependent Claim
17 words
The dispensing device according to claim 21 wherein the first layer additionally comprises an osmotically effective solute.
Claim 26
Dependent Claim
17 words
The dispensing device according to claim 21 wherein the second layer additionally comprises an osmotically effective solute.
Claim 27
Dependent Claim
20 words
The dispensing device according to claim 21 wherein the first and second layers each additionally comprise an osmotically effective solute.
Claim 28
Dependent Claim
23 words
The dispensing device according to claim 21 wherein the coating containing at least one hole comprises a polymer and one or more porosigens.
Claim 29
Dependent Claim
54 words
A dispensing device which comprises: (a) a mixture comprising a beneficial agent and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and (b) a coating containing a least one hole which coating surrounds the mixture.
Claim 30
Dependent Claim
54 words
A dispensing device which comprises: (a) a mixture comprising a beneficial agent and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and (b) a coating containing a least one hole which coating surrounds the mixture.
Claim 31
Dependent Claim
14 words
The dispensing device according to claim 26 wherein the beneficial agent is a drug.
Claim 32
Dependent Claim
15 words
The dispensing device according to claim 27 wherein the lyotropic liquid crystal is a phospholipid.
Claim 33
Dependent Claim
13 words
The dispensing device according to claim 28 wherein the coating comprises cellulose acetate.
Claim 34
Dependent Claim
16 words
The dispensing device according to claim 26 wherein the mixture additionally comprises an osmotically effective solute.
Claim 35
Dependent Claim
16 words
The dispensing device according to claim 26 wherein at least one hole passes through the device.
Claim 36
Dependent Claim
96 words
A dispensing device which comprises: (a) a first layer comprising a mixture of a beneficial agent and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and (b) a second layer comprising a lyotropic liquid crystal which second layer is adjacent to the first layer and comprising an area in contact with the first layer; and (c) a coating containing a plurality of pores which coating surrounds the first and second layers except for said area in contact.
Claim 37
Dependent Claim
96 words
A dispensing device which comprises: (a) a first layer comprising a mixture of a beneficial agent and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and (b) a second layer comprising a lyotropic liquid crystal which second layer is adjacent to the first layer and comprising an area in contact with the first layer; and (c) a coating containing a plurality of pores which coating surrounds the first and second layers except for said area in contact.
Claim 38
Dependent Claim
17 words
The dispensing device according to claim 32 wherein the first layer additionally comprises an osmotically effective solute.
Claim 39
Dependent Claim
17 words
The dispensing device according to claim 32 wherein the second layer additionally comprises an osmotically effective solute.
Claim 40
Dependent Claim
20 words
The dispensing device according to claim 32 wherein the first and second layers each additionally comprise an osmotically effective solute.
Claim 41
Dependent Claim
100 words
A dispensing device which comprises: (a) a first layer comprising a mixture of a beneficial agent and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and (b) a second layer comprising a lyotropic liquid crystal which second layer is adjacent to the first layer and comprises an area in contact with the first layer; and (c) a coating which surrounds the first and second layers except for said area in contact and which comprises a polymer and one or more porosigens.
Claim 42
Dependent Claim
100 words
A dispensing device which comprises: (a) a first layer comprising a mixture of a beneficial agent and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and (b) a second layer comprising a lyotropic liquid crystal which second layer is adjacent to the first layer and comprises an area in contact with the first layer; and (c) a coating which surrounds the first and second layers except for said area in contact and which comprises a polymer and one or more porosigens.
Claim 43
Dependent Claim
17 words
The dispensing device according to claim 36 wherein the first layer additionally comprises an osmotically effective solute.
Claim 44
Dependent Claim
17 words
The dispensing device according to claim 36 wherein the second layer additionally comprises an osmotically effective solute.
Claim 45
Dependent Claim
20 words
The dispensing device according to claim 36 wherein the first and second layers each additionally comprise an osmotically effective solute.
Claim 46
Dependent Claim
30 words
A method for the controlled delivery of one or more beneficial agents to an environment of use which comprises placing the device of claim 1 into the environment of use.
Claim 47
Dependent Claim
30 words
A method for the controlled delivery of one or more beneficial agents to an environment of use which comprises placing the device of claim 8 into the environment of use.
Claim 48
Dependent Claim
30 words
A method for the controlled delivery of one or more beneficial agents to an environment of use which comprises placing the device of claim 21 into the environment of use.
Claim 49
Dependent Claim
30 words
A method for the controlled delivery of one or more beneficial agents to an environment of use which comprises placing the device of claim 26 into the environment of use.
Claim 50
Dependent Claim
30 words
A method for the controlled delivery of one or more beneficial agents to an environment of use which comprises placing the device of claim 32 into the environment of use.
Claim 51
Dependent Claim
30 words
A method for the controlled delivery of one or more beneficial agents to an environment of use which comprises placing the device of claim 36 into the environment of use.
Claim 52
Dependent Claim
31 words
A method for the controlled delivery of a drug to an animal which comprises administering to the animal the device according to claim 8 wherein the beneficial agent is a drug.
References Cited (Backward Citations)
US3538214A
Cited
US3995631A
Cited
US3845770A
Cited
US4160020A
Cited
US4111202A
Cited
US4180073A
Cited
US4217898A
Cited
US4350271A
Cited
US4327725A
Cited
US4449988A
Cited
US4439196A
Cited
US4940576A
Cited
US4673405A
Cited
US4783337A
Cited
US4765989A
Cited
GB2140687A
Cited
GB2150830A
Cited
GB2155787A
Cited
US4927633A
Cited
US5000957A
Cited
US4684524A
Cited
US4678467A
Cited
US4615698A
Cited
EP0169105A2
Cited
US4608048A
Cited
US4685918A
Cited
EP0190969A2
Cited
US4627971A
Cited
US4666704A
Cited
US4772474A
Cited
US4966767A
Cited
US4963141A
Cited
US4955881A
Cited
US4784858A
Cited
EP0233009A2
Cited
US4867969A
Cited
GB2189995A
Cited
EP0248447A2
Cited
EP0250374B1
Cited
EP0253541A2
Cited
US4857336A
Cited
GB2193632A
Cited
DE3629994A1
Cited
EP0277092A1
Cited
US4892778A
Cited
US4876093A
Cited
US4915949A
Cited
US4859470A
Cited
US4902514A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-04-28 | 1995-10-28 | 1996-04-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-04-28 | 1999-10-28 | 2000-04-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-04-28 | 2003-10-28 | 2004-04-28 | $7700.00 | Window Closed / Lapsed |