US4859470A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dosage form for delivering diltiazem
Assignee: Alza Corp
•
Filing: 1988-06-02
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Granted: 1989-08-22
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Expires: 2008-06-02
Abstract
Abstract A device is disclosed for delivering diltiazem at a controlled and substantially zero order rate over a prolonged period of time.
Inventors
- 👤 George V. Guittard
- 👤 Patrick S. L. Wong
- 👤 Felix Theeuwes
- 👤 Richard Cortese
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 08:22
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2072; A61K9/2086; A61K9/209; A61K9/0002; A61K9/0004; A61K31/00; A61K31/33; A61K31/395; A61K31/55; A61P; A61P9/00; A61P9/08; A61P9/10
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
160 words
A device for delivering diltiazem, comprising: (a) a wall that surrounds and forms; (b) a compartment; (c) a diltiazem composition in the compartment comprising from 70 wt % to 96 wt % of a member selected from the group consisting of diltiazem and its pharmaceutically acceptable salts, from 0.5 wt % to 15 wt % of a polyacrylic acid comprising a 2,500,000 to 4,000,000 molecular weight, from 0.5 wt % to 20 wt % of poly(ethylene oxide) comprising a 4,000,000 to 5,500,000 molecular weight and from 0.5 wt % to 20 wt % of a poly(vinylpyrrolidone) comprising a 35,000 to 40,000 molecular weight; (d) a push composition in the compartment comprising 70 wt % to 95 wt % poly(ethylene oxide) comprising a 6,200,000 to 7,500,000 molecular weight, from 1 wt % to 15 wt % of a hydroxypropylmethylcellulose comprising a 9,000 to 16,000 molecular weight; and, (e) at least one passageway in the wall for delivering diltiazem from the device.
Claim 2
Independent Claim
160 words
A device for delivering diltiazem, comprising: (a) a wall that surrounds and forms; (b) a compartment; (c) a diltiazem composition in the compartment comprising from 70 wt % to 96 wt % of a member selected from the group consisting of diltiazem and its pharmaceutically acceptable salts, from 0.5 wt % to 15 wt % of a polyacrylic acid comprising a 2,500,000 to 4,000,000 molecular weight, from 0.5 wt % to 20 wt % of poly(ethylene oxide) comprising a 4,000,000 to 5,500,000 molecular weight and from 0.5 wt % to 20 wt % of a poly(vinylpyrrolidone) comprising a 35,000 to 40,000 molecular weight; (d) a push composition in the compartment comprising 70 wt % to 95 wt % poly(ethylene oxide) comprising a 6,200,000 to 7,500,000 molecular weight, from 1 wt % to 15 wt % of a hydroxypropylmethylcellulose comprising a 9,000 to 16,000 molecular weight; and, (e) at least one passageway in the wall for delivering diltiazem from the device.
Claim 3
Dependent Claim
24 words
The device for delivering diltiazem according to claim 1, wherein the diltiazem is delivering at a substantially zero order rate of delivery over time.
Claim 4
Dependent Claim
16 words
The device for delivering diltiazem according to claim 1, wherein the wall comprises a cellulose acetate.
Claim 5
Dependent Claim
14 words
The device for delivering diltiazem according to claim 1, wherein the wall comprises hydroxypropylmethylcellulose.
Claim 6
Dependent Claim
21 words
The device for delivering diltiazem according to claim 1, wherein the wall comprises cellulose acetate having an acetyl content of 39.8%.
Claim 7
Dependent Claim
15 words
The device for delivering diltiazem according to claim 1, wherein the wall comprises ethyl cellulose.
Claim 8
Dependent Claim
20 words
The device for delivering diltiazem according to claim 1, wherein the wall comprises at least in part a microporous composition.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-08-21 | 1993-02-20 | 1993-08-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-08-21 | 1997-02-20 | 1997-08-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-08-21 | 2001-02-20 | 2001-08-22 | $7700.00 | Window Closed / Lapsed |