US4927633A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dispenser for delivering drug to livestock
Assignee: Alza Corp
•
Filing: 1987-06-24
•
Granted: 1990-05-22
•
Expires: 2007-06-24
Abstract
Abstract A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space, (2) heat responsive means containing a beneficial agent in the spece, (3) means for increasing the amount of beneficial agent delivered from the device in the space, (4) expandable means in the space, (5) an optional dense means in the space, and (6) means in the housing for delivering the beneficial agent from the dispensing device.
Inventors
- 👤 James B. Eckenhoff
- 👤 Richard Cortese
- 👤 Felix A. Landrau
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 09:06
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0068; A61K9/0002; A61K9/0004; A61M; A61M31/00; A61M31/002
Claims Analysis
Total Claims: 43
Claim 1
Independent Claim
141 words
A dispensing device for delivering a beneficial agent formulation to an environment of use, the dispensing device comprising (a) a wall that defines an internal space, said wall comprising in at least a part a composition that permits the passage of fluid; (b) a beneficial agent formulation in the space, said formulation comprising selenium; (c) an expandable composition in the space for urging the beneficial agent formulation from the device; (d) a layer of a composition comprising means for maintaining the identity of the beneficial agent formulation and the expandable composition in the space between the beneficial agent formulation and the expandable composition; (e) a density member in the space comprising a density for maintaining the device in the environment of use; and (f) exit means in the wall for dispensing the beneficial selenium to the environment of use over time.
Claim 2
Dependent Claim
141 words
A dispensing device for delivering a beneficial agent formulation to an environment of use, the dispensing device comprising (a) a wall that defines an internal space, said wall comprising in at least a part a composition that permits the passage of fluid; (b) a beneficial agent formulation in the space, said formulation comprising selenium; (c) an expandable composition in the space for urging the beneficial agent formulation from the device; (d) a layer of a composition comprising means for maintaining the identity of the beneficial agent formulation and the expandable composition in the space between the beneficial agent formulation and the expandable composition; (e) a density member in the space comprising a density for maintaining the device in the environment of use; and (f) exit means in the wall for dispensing the beneficial selenium to the environment of use over time.
Claim 3
Dependent Claim
35 words
The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the selenium is a member selected from the group consisting of selenium disulfide and sodium selenite.
Claim 4
Dependent Claim
29 words
The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the wall composition comprises cellulose acetate butyrate and cellulose acetate.
Claim 5
Dependent Claim
34 words
The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the wall comprises cellulose acetate butyrate, cellulose acetate, tributyl citrate, triethyl citrate, and polyethylene glycol.
Claim 6
Dependent Claim
35 words
The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the expandable composition comprises a member selected from the group consisting of carboxymethylcellulose and sodium carboxymethylcellulose.
Claim 7
Dependent Claim
28 words
The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the expandable composition comprises sodium carboxymethylcellulose and sodium chloride.
Claim 8
Dependent Claim
148 words
A dispensing device for delivering a beneficial agent formulation to an environment of use, the dispensing device comprising: (a) a wall that defines an internal space, said wall comprising in at least a part a composition that permits the passage of fluid; (b) a beneficial agent formulation in the space, said formulation comprising selenium; (c) an expandable composition in the space for urging the beneficial agent formulation from the device, said expandable composition comprising a carboxyvinyl polymer; (d) a layer of a composition comprising means for maintaining the identity of the beneficial agent formulation and the expandable composition in the space between the beneficial agent formulation and the expandable composition; (e) a density member in the space comprising a density for maintaining the device in the environment of use; and (f) exit means in the wall for dispensing the beneficial selenium to the environment of use over time.
Claim 9
Dependent Claim
148 words
A dispensing device for delivering a beneficial agent formulation to an environment of use, the dispensing device comprising: (a) a wall that defines an internal space, said wall comprising in at least a part a composition that permits the passage of fluid; (b) a beneficial agent formulation in the space, said formulation comprising selenium; (c) an expandable composition in the space for urging the beneficial agent formulation from the device, said expandable composition comprising a carboxyvinyl polymer; (d) a layer of a composition comprising means for maintaining the identity of the beneficial agent formulation and the expandable composition in the space between the beneficial agent formulation and the expandable composition; (e) a density member in the space comprising a density for maintaining the device in the environment of use; and (f) exit means in the wall for dispensing the beneficial selenium to the environment of use over time.
Claim 10
Dependent Claim
36 words
The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 7, wherein the selenium is a member selected from the group consisting of selenium, selenium disulfide and sodium selenite.
Claim 11
Dependent Claim
28 words
A dispensing device for delivering the beneficial agent formulation to an environment of use according to claim 7, wherein the wall comprises cellulose acetate butyrate and cellulose acetate.
Claim 12
Dependent Claim
34 words
The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 7, wherein the wall comprises cellulose acetate butyrate, cellulose acetate, tributyl citrate, triethyl citrate and polyethylene glycol.
Claim 13
Dependent Claim
26 words
The dispensing device for delivering the beneficial agent to the environment of use according to claim 7, wherein the exit means comprises a plurality of pores.
Claim 14
Dependent Claim
141 words
A dispensing device for delivering a beneficial agent formulation to an environment of use the dispensing device comprising: (a) a wall that defines an internal space, said wall comprising in at least a part a composition that permits the passage of fluid; (b) a beneficial agent formulation in the space, said formulation comprising avermectin; (c) an expandable composition in the space for urging the beneficial agent formulation from the device; (d) a layer of a composition comprising means for maintaining the identity of the beneficial agent formulation and the expandable composition in the space between the beneficial agent formulation and the expandable composition; (e) a density member in the space comprising a density for maintaining the device in the environment of use; and (f) exit means in the wall for dispensing the beneficial avermectin to the environment of use over time.
Claim 15
Dependent Claim
141 words
A dispensing device for delivering a beneficial agent formulation to an environment of use the dispensing device comprising: (a) a wall that defines an internal space, said wall comprising in at least a part a composition that permits the passage of fluid; (b) a beneficial agent formulation in the space, said formulation comprising avermectin; (c) an expandable composition in the space for urging the beneficial agent formulation from the device; (d) a layer of a composition comprising means for maintaining the identity of the beneficial agent formulation and the expandable composition in the space between the beneficial agent formulation and the expandable composition; (e) a density member in the space comprising a density for maintaining the device in the environment of use; and (f) exit means in the wall for dispensing the beneficial avermectin to the environment of use over time.
Claim 16
Dependent Claim
28 words
A dispensing device for delivering the beneficial agent formulation to an environment of use according to claim 12, wherein the wall comprises cellulose acetate butyrate and cellulose acetate.
Claim 17
Dependent Claim
34 words
The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 12, wherein the wall comprises cellulose acetate butyrate, cellulose acetate, tributyl citate, triethyl citrate, and polyethylene glycol.
Claim 18
Dependent Claim
35 words
The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 12 wherein the expandable composition comprises a member selected from the group consisting of carboxymethylcellulose and sodium carboxymethylcellulose.
Claim 19
Dependent Claim
28 words
The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 12, wherein the expandable member comprises sodium carboxymethylcellulose and sodium chloride.
Claim 20
Dependent Claim
26 words
The dispensing device for delivering the beneficial agent to the environment of use according to claim 12, wherein the exit means comprises a plurality of pores.
Claim 21
Dependent Claim
22 words
The dispensing device for delivering the beneficial agent to the environment of use according to claim 12, wherein the avermectin is ivermectin.
Claim 22
Dependent Claim
148 words
A dispensing device for delivering a beneficial agent formulation to an environment of use, the dispensing device comprising: (a) a wall that defines an internal space, said wall comprising in at least a part a composition that permits the passage of fluid; (b) a beneficial agent formulation in the space, said formulation comprising avermectin; (c) an expandable composition in the space for urging the beneficial agent formulation from the device, said expandable composition comprising a carboxyvinyl polymer; (d) a layer of a composition comprising means for maintaining the identity of the beneficial agent formulation and the expandable composition in the space between the beneficial agent formulation and the expandable composition; (e) a density member in the space comprising a density for maintaining the device in the environment of use; and (f) exit means in the wall for dispensing the beneficial avermectin to the environment of use over time.
Claim 23
Dependent Claim
148 words
A dispensing device for delivering a beneficial agent formulation to an environment of use, the dispensing device comprising: (a) a wall that defines an internal space, said wall comprising in at least a part a composition that permits the passage of fluid; (b) a beneficial agent formulation in the space, said formulation comprising avermectin; (c) an expandable composition in the space for urging the beneficial agent formulation from the device, said expandable composition comprising a carboxyvinyl polymer; (d) a layer of a composition comprising means for maintaining the identity of the beneficial agent formulation and the expandable composition in the space between the beneficial agent formulation and the expandable composition; (e) a density member in the space comprising a density for maintaining the device in the environment of use; and (f) exit means in the wall for dispensing the beneficial avermectin to the environment of use over time.
Claim 24
Dependent Claim
28 words
A dispensing device for delivering the beneficial agent formulation to an environment of use according to claim 19, wherein the wall comprises cellulose acetate butyrate and cellulose acetate.
Claim 25
Dependent Claim
34 words
The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 19, wherein the wall comprises cellulose acetate butyrate, cellulose acetate, tributyl citrate, triethyl citrate, and polyethylene glycol.
Claim 26
Dependent Claim
21 words
The dispensing device for delivering the beneficial agent formulation according to claim 19, wherein the carboxyvinyl polymer is a carboxypolymethylene polymer.
Claim 27
Dependent Claim
27 words
The dispensing device for delivering the beneficial agent formulation according to claim 19, wherein the carboxyvinyl polymer is a polymer of acrylic acid cross-linked with polyallyl sucrose.
Claim 28
Dependent Claim
28 words
The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 19, wherein the expandable composition comprises carboxyvinyl polymer and sodium chloride.
Claim 29
Dependent Claim
30 words
The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 19, wherein the expandable composition comprises carboxyvinyl polymer, sodium chloride, and polyvinyl pyrrolidone.
Claim 30
Dependent Claim
32 words
The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 19, wherein the expandable composition comprises carboxyvinyl polymer, sodium chloride, polyvinyl pyrrolidone, and magnesium stearate.
Claim 31
Dependent Claim
27 words
The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 19, wherein the exit means comprises a plurality of pores.
Claim 32
Dependent Claim
23 words
The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 19, wherein the avermectin is ivermectin.
Claim 33
Dependent Claim
92 words
A dispensing device for delivering a beneficial agent to an environment of use, the dispensing device comprising: (a) a wall; (b) an internal lumen defined by the wall; (c) a beneficial agent formulation comprising a lasolocid in the lumen; (d) a composition in the lumen for pushing the beneficial agent formulation from the device; (e) a density member in the lumen comprising a density for maintaining the device in the environment of use; and, (f) exit means in the device for dispensing the beneficial lasolocid to the environment of use over time.
Claim 34
Dependent Claim
92 words
A dispensing device for delivering a beneficial agent to an environment of use, the dispensing device comprising: (a) a wall; (b) an internal lumen defined by the wall; (c) a beneficial agent formulation comprising a lasolocid in the lumen; (d) a composition in the lumen for pushing the beneficial agent formulation from the device; (e) a density member in the lumen comprising a density for maintaining the device in the environment of use; and, (f) exit means in the device for dispensing the beneficial lasolocid to the environment of use over time.
Claim 35
Dependent Claim
71 words
The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 29, wherein the composition for pushing the beneficial agent formulation comprises a member selected from the group consisting of carboxymethylcellulose, sodium carboxymethylcellulose, a composition comprising carboxymethylcellulose and sodium chloride, a composition comprising a carboxyvinyl polymer, sodium chloride and polyvinyl pyrrolidone, and a composition comprising a carboxyvinyl polymer, sodium chloride, polyvinyl pyrrolidone and magnesium stearate.
Claim 36
Dependent Claim
27 words
The dispensing device for delivering the beneficial agent to the environment of use according to claim 29, wherein the wall comprises cellulose acetate butyrate and cellulose acetate.
Claim 37
Dependent Claim
26 words
The dispensing device for delivering the beneficial agent to the environment of use according to claim 29, wherein the wall comprises tributyl citrate and triethyl citrate.
Claim 38
Dependent Claim
124 words
A dispensing device for delivering a beneficial agent to an environment of use, the dispensing device comprising: (a) a wall; (b) an internal lumen defined by the wall; (c) a beneficial agent comprising an ionophere in the lumen; (d) means in the lumen for pushing the beneficial ionophere from the device; (e) means for maintaining the identity of the beneficial ionophere and the means for pushing the ionophere from the device, said means for maintaining the identity in the lumen between the beneficial ionophere and the means for pushing; (f) a density member in the lumen for maintaining the device in the environment of use; and, (g) exit means in the device for dispensing the beneficial ionophere to the environment of use over time.
Claim 39
Dependent Claim
124 words
A dispensing device for delivering a beneficial agent to an environment of use, the dispensing device comprising: (a) a wall; (b) an internal lumen defined by the wall; (c) a beneficial agent comprising an ionophere in the lumen; (d) means in the lumen for pushing the beneficial ionophere from the device; (e) means for maintaining the identity of the beneficial ionophere and the means for pushing the ionophere from the device, said means for maintaining the identity in the lumen between the beneficial ionophere and the means for pushing; (f) a density member in the lumen for maintaining the device in the environment of use; and, (g) exit means in the device for dispensing the beneficial ionophere to the environment of use over time.
Claim 40
Dependent Claim
66 words
The dispensing device for delivering the beneficial ionophere to the environment of use according to claim 33, wherein the means for pushing comprise a member selected from the group consisting of carboxymethylcellulose, sodium carboxymethylcellulose, a composition comprising carboxymethylcellulose and sodium chloride, a composition comprising a carboxyvinyl polymer, sodium chloride and polyvinyl pyrrolidone, and a composition comprising a carboxyvinyl polymer, sodium chloride, polyvinyl pyrrolidone and magnesium stearate.
Claim 41
Dependent Claim
27 words
The dispensing device for delivering the beneficial ionophere to the environment of use according to claim 33, wherein the wall comprises cellulose acetate butyrate and cellulose acetate.
Claim 42
Dependent Claim
26 words
The dispensing device for delivering the beneficial ionophere to the environment of use according to claim 33, wherein the wall comprises tributyl citrate and triethyl citrate.
Claim 43
Dependent Claim
34 words
The dispensing device for delivering the beneficial ionophere to the environment of use according to claim 33, wherein the ionophere is a member selected from the group consisting of lasalocid, salinomycin, virginiamycin and ronnel.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-05-21 | 1993-11-20 | 1994-05-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-05-21 | 1997-11-20 | 1998-05-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-05-21 | 2001-11-20 | 2002-05-22 | $7700.00 | Window Closed / Lapsed |