US4772474A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dispenser with internal arrangement of lamina means for dispensing beneficial agent
Assignee: Alza Corp
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Filing: 1986-08-11
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Granted: 1988-09-20
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Expires: 2006-08-11
Abstract
Abstract A dispensing system is disclosed comprising a wall surrounding a lumen. The lumen comprises (1) a thermo responsive composition comprising a beneficial agent, (2) means for occupying space in the lumen for pushing the thermo responsive composition from the dispensing system, and (3) means for enhancing the amount of the beneficial agent dispensed from the system positioned between the thermo responsive composition and the means for occupying space.
Inventors
- 👤 James B. Eckenhoff
- 👤 Richard Cortese
- 👤 Felix A. Landrau
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 00:49
CPC Classifications
A; A61; A61M; A61M31/00; A61M31/002; A61K; A61K9/00; A61K9/0002; A61K9/0004
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
157 words
A delivery system for delivering a beneficial agent formulation to an environment of use, the delivery system comprising: (a) a wall that surrounds and defines an internal lumen, the wall comprising a semipermeable composition that is permeable to the passage of fluid and substantially impermeable to the passage of a beneficial agent; (b) a hydrogel composition in the lumen which expands and occupies an increased volume of the lumen upon imbibing fluid; (c) a heat sensitive beneficial agent formulation in the lumen that forms a dispensable formulation at a temperature of at least 25° C.; (d) lamina means in the lumen for lessening the incidence of mixing of the heat-sensitive beneficial agent formulation with the hydrogel composition, said lamina means being positioned between the heat-sensitive beneficial agent formulation and the hydrogel composition; and (e) means in the delivery system for communicating with the lumen for delivering the beneficial agent formulation to the environement of use over time.
Claim 2
Dependent Claim
157 words
A delivery system for delivering a beneficial agent formulation to an environment of use, the delivery system comprising: (a) a wall that surrounds and defines an internal lumen, the wall comprising a semipermeable composition that is permeable to the passage of fluid and substantially impermeable to the passage of a beneficial agent; (b) a hydrogel composition in the lumen which expands and occupies an increased volume of the lumen upon imbibing fluid; (c) a heat sensitive beneficial agent formulation in the lumen that forms a dispensable formulation at a temperature of at least 25° C.; (d) lamina means in the lumen for lessening the incidence of mixing of the heat-sensitive beneficial agent formulation with the hydrogel composition, said lamina means being positioned between the heat-sensitive beneficial agent formulation and the hydrogel composition; and (e) means in the delivery system for communicating with the lumen for delivering the beneficial agent formulation to the environement of use over time.
Claim 3
Dependent Claim
35 words
The delivery system for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the means in the delivery system for delivering the beneficial agent comprises at least one passageway.
Claim 4
Dependent Claim
37 words
The delivery system for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the wall that surrounds and defines the internal lumen comprises in at least a part a microporous member.
Claim 5
Dependent Claim
37 words
The delivery system for delivering the beneficial agent formulation to the environment of use according to claim 1, where the wall means that surrounds and defines the compartment comprises in at least a part an impermeable member.
Claim 6
Dependent Claim
39 words
The delivery system for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the wall that surrounds and defines the internal lumen comprises a microporous member laminated in part by a semipermeable member.
Claim 7
Dependent Claim
25 words
The delivery system for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the hydrogel composition contains an osmagnet.
Claim 8
Dependent Claim
59 words
The delivery system for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the wall comprises a member selected from the group consisting of a cellulose ester, cellulose diester, cellulose triester, cellulose ether, cellulose ester-ether, cellulose acylate, cellulose diacylate, cellulose triacylate, cellulose acetate, cellulose acetate butyrate, cellulose propionate morpholinobutrate, and cellulose acetate phthalate.
Claim 9
Dependent Claim
49 words
The delivery system for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the delivery system further comprises means in the lumen for maintaining the delivery system in the environment of use over time, said means having a density of at least 1.2.
Claim 10
Dependent Claim
25 words
The delivery system for delivering a beneficial agent formulation to the environment of use according to claim 1, wherein the beneficical agent formulation comprises avermectin.
Claim 11
Dependent Claim
25 words
The delivery system for delivering a beneficial agent formulation to the environment of use according to claim 1, wherein the beneficial agent formulation comprises ivermectin.
Claim 12
Dependent Claim
36 words
The delivery system for delivering a beneficial agent formulation to the environment of use according to claim 1, wherein the heat-sensitive beneficial agent formulation comprises a block copolymer comprising 1,2-butylene oxide and ethylene oxide and ivermectin.
Claim 13
Dependent Claim
32 words
The delivery system for delivering a beneficial agent formulation to the environment of use according to claim 1, wherein the heat sensitive beneficial agent formulation comprises a food grade wax and ivermectin.
Claim 14
Dependent Claim
28 words
The delivery system for delivering a beneficial agent formulation to the environment of use according to claim 1, wherein the wall comprises cellulose acetate butyrate and polyethylene glycol.
Claim 15
Dependent Claim
52 words
The delivery system for delivering a beneficial agent formulaion to the environment of use according to claim 8, wherein the means for maintaining the delivery system in the environment of use comprises a member selected from the group consisting of iron, steel, iron magnesium alloy, and a mixture of cobalt and iron.
Claim 16
Dependent Claim
36 words
The delivery system for delivering a beneficial agent formulation to the environment of use according to claim 1, further comprising a body member located between the wall and at least the heat sensitive beneficial agent formulation.
Claim 17
Dependent Claim
24 words
The delivery system for delivering a beneficial agent formulation to the environment of use according to claim 15, wherein the body member comprises gelatin.
Claim 18
Dependent Claim
26 words
The delivery system for delivering a beneficial agent formulation to the environment of use according to claim 1, wherein the lamina means comprises a single lamina.
Claim 19
Dependent Claim
27 words
The delivery system for delivering a beneficial agent formulation to the environment of use according to claim 8, wherein the lamina means comprises a plurality of laminae.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-09-20 | 1992-03-21 | 1992-09-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-09-20 | 1996-03-21 | 1996-09-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-09-20 | 2000-03-21 | 2000-09-20 | $7700.00 | Window Closed / Lapsed |