US4180073A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Device for delivering drug to biological environment
Assignee: Alza Corp
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Filing: 1977-08-29
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Granted: 1979-12-25
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Expires: 1997-08-29
Abstract
Abstract A self-powered device for delivering drug is disclosed. The device comprises (1) a substantially rigid housing, (2) a collapsible container storing a drug and having a passageway for delivering the drug in the housing, and (3) an expandable laminate positioned between the housing and the container. The laminate comprises (a) a lamina formed of an absorbent material laminated to (b) a lamina placed adjacent to the container and formed of a swellable hydrophilic polymer. In operation, when the device is in a biological environment, fluid from the environment is imbibed by the laminate into the housing causing the laminate to expand and exert pressure on the container, thereby collapsing the container and concomitantly pumping drug through the passageway from the device at a correspondingly controlled rate over a prolonged period of time.
Inventors
- 👤 Alan S. Michaels
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 18:59
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0002; A61K9/0004; A61M; A61M31/00; A61M31/002
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
140 words
A drug delivery device comprising: (a) a drug; (b) a housing having a shape-retaining wall defining an internal space, said housing having at least one opening connecting the space with the exterior of the device; (c) a container in the housing, said container having a collapsible wall surrounding a reservoir for storing the drug and a passageway for delivering drug from the container to the exterior of the device; and, (d) a laminate in the housing surrounding the container comprising a lamina of an absorbent material and a lamina of a swellable hydrophilic cross-linked polymer, said laminate capable of imbibing fluid into the housing thereby causing the laminate to expand and exert pressure on the container which collapses said container and concomitantly pumps drug through the passageway from the device at a controlled rate over a prolonged period of time.
Claim 2
Dependent Claim
140 words
A drug delivery device comprising: (a) a drug; (b) a housing having a shape-retaining wall defining an internal space, said housing having at least one opening connecting the space with the exterior of the device; (c) a container in the housing, said container having a collapsible wall surrounding a reservoir for storing the drug and a passageway for delivering drug from the container to the exterior of the device; and, (d) a laminate in the housing surrounding the container comprising a lamina of an absorbent material and a lamina of a swellable hydrophilic cross-linked polymer, said laminate capable of imbibing fluid into the housing thereby causing the laminate to expand and exert pressure on the container which collapses said container and concomitantly pumps drug through the passageway from the device at a controlled rate over a prolonged period of time.
Claim 3
Dependent Claim
39 words
The drug delivery device according to claim 1, wherein the lamina formed of an absorbent material has a surface in contact with the housing and a surface in laminar arrangement with the lamina formed of the swellable hydrophilic polymer.
Claim 4
Dependent Claim
25 words
The drug delivery device according to claim 1, wherein the lamina formed of the swellable hydrophilic polymer has a surface in contact with the container.
Claim 5
Dependent Claim
35 words
The drug delivery device according to claim 1, wherein the lamina formed of the absorbent material is formed of a member selected from the group consisting of wool, cotton, straw, flax, paper and mixtures thereof.
Claim 6
Dependent Claim
42 words
The drug delivery device according to claim 1, wherein the container is formed of a member selected from the group consisting of natural rubber, gutta percha, cyclised rubber, synthetic isoprene rubber, butadiene rubber, styrene-butadiene rubber, nitrile rubber, chloroprene rubber and ethylene-propylene rubber.
Claim 7
Dependent Claim
43 words
The drug delivery device according to claim 1, wherein the swellable hydrophilic polymer is cross-linked and it is a member selected from the group consisting of cross-linked poly(hydroxyalkyl methacrylates), poly(N-vinyl-2-pyrrolidone), polyelectrolyte complexes, poly(vinyl alcohol) cross-linked with glyoxal, formaldehyde or glutaraldehyde, and cross-linked celluloses.
Claim 8
Dependent Claim
52 words
The drug delivery device according to claim 1, wherein the drug is a member selected from the group consisting of locally and systemically acting gastrointestinal, central nervous system, hypnotic, sedative, psychic energizer, tranquilizer, anticonvulsant, antiparkinson, muscle relaxant, analgesic, antipyretic, anti-inflammatory, anesthetic, antispasmodic, antimicrobial, antiviral, antiulcer, hormonal, sympathomimetic, diuretic, hypoglycemic, and anticontraceptive drug.
Claim 9
Dependent Claim
21 words
The drug delivery device according to claim 1, wherein the drug in the container is mixed with a pharmaceutically acceptable carrier.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-12-24 | 1983-06-25 | 1983-12-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-12-24 | 1987-06-25 | 1987-12-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-12-24 | 1991-06-25 | 1991-12-25 | $7700.00 | Window Closed / Lapsed |