Dispensing system for administering beneficial agent formulation to ruminants

Claim 2

A dispensing device for delivering a beneficial agent formulation to an aqueous environment of use, the dispensing device comprising: (a) wall means for surrounding and forming an internal compartment, said wall means comprising in at least a part a semipermeable composition permeable to the passage of aqueous fluid present in the environment of use; (b) a beneficial agent formulation in the compartment, which beneficial agent formulation exhibits an osmotic pressure gradient across the semipermeable wall against an aqueous fluid present in the environment of use and forms with the aqueous fluid that enters the compartment through the wall a dispensable aqueous beneficial agent formulation; (c) means in the compartment for absorbing aqueous fluid from the environment of use for occupying an increasing amount of space in the compartment; (d) means in the compartment for increasing the weight of the dispensing device, said means having a density from 1 to 8 and in contact with at least one of said beneficial agent formulation or said means for absorbing aqueous fluid; and, (e) means in the wall connecting the exterior of the dispensing device with the compartment for delivering the beneficial agent aqueous formulation to the environment of use.

Claim 3

The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the means in the compartment for increasing the weight of the dispensing device comprises a unit body shaped and sized for occupying a selected area of the internal compartment.

Claim 4

The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the means in the wall connecting the exterior of the device with the compartment comprises at least one passageway in the wall.

Claim 5

The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the means in the wall connecting the exterior of the device with the compartment comprises at least two passageways in the wall.

Claim 6

The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the beneficial agent formulation comprises a member selected from the group consisting of an osmagent and an osmopolymer.

Claim 7

The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the means for absorbing fluid is an expandable hydrogel.

Claim 8

The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the beneficial agent formulation comprises a member selected from the group consisting of mebendazole, levamisole, albendazole, cambendazole, fenbendazole, parbendazole, oxfendazole, thiabendazole, tichlorfan, praziquantel, morantel, pyrantel, avermectin, ivermectin, oxantel, piperazine, diethylcarbamazine, tetramisole, polaxalene, selenium, and zearalanol.

Claim 9

A dispensing device for delivering a beneficial agent formulation to an aqueous-fluid environment of use, wherein the dispensing device comprises: (a) wall means for surrounding and forming an internal compartment, said wall comprising in at least a part a composition pervious to the passage of an aqueous fluid present in the environment of use; (b) means in the compartment for absorbing and imbibing aqueous fluid into the compartment for expanding and occupying an increasing volume of the compartment; (c) a beneficial agent formulation in the compartment, said beneficial agent formulation imbibing aqueous fluid into the compartment for forming with the beneficial agent a dispensable aqueous-like formulation; (d) means in the compartment for increasing the weight of the dispensing device, said means having a density from 1 to 8 and comprising a solid unit body and positioned between the beneficial agent formulation and the means for expanding in the compartment, and wherein upon the means for expanding absorbs and imbibes aqueous fluid said means expands and pushes said means for increasing the weight of the dispensing device against said beneficial agent aqueous formulation, whereby said beneficial agent aqueous formulation is pushed into; (e) passageway means in the dispensing device for delivering the beneficial agent aqueous formulation to the environment of use.

Claim 10

A dispensing device for delivering a beneficial agent formulation to an aqueous-fluid environment of use, wherein the dispensing device comprises: (a) wall means for surrounding and forming an internal compartment, said wall comprising in at least a part a composition pervious to the passage of an aqueous fluid present in the environment of use; (b) means in the compartment for absorbing and imbibing aqueous fluid into the compartment for expanding and occupying an increasing volume of the compartment; (c) a beneficial agent formulation in the compartment, said beneficial agent formulation imbibing aqueous fluid into the compartment for forming with the beneficial agent a dispensable aqueous-like formulation; (d) means in the compartment for increasing the weight of the dispensing device, said means having a density from 1 to 8 and comprising a solid unit body and positioned between the beneficial agent formulation and the means for expanding in the compartment, and wherein upon the means for expanding absorbs and imbibes aqueous fluid said means expands and pushes said means for increasing the weight of the dispensing device against said beneficial agent aqueous formulation, whereby said beneficial agent aqueous formulation is pushed into; (e) passageway means in the dispensing device for delivering the beneficial agent aqueous formulation to the environment of use.