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US5880112A Expired / Lapsed US ⏱️ 0.0 years remaining

Naaladase inhibitors

Assignee: Eisai Inc
•
Filing: 1997-04-08
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Granted: 1999-03-09
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Expires: 2017-04-08
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Abstract

Abstract The present disclosure relates to dipeptidase inhibitors, and more particularly, to N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) enzyme inhibitors which are proposed as novel agents for the treatment of prostate cancer. NAALADase is enzyme which is a membrane-bound metalloprotease which hydrolyzes the dipeptide, N-acetyl-L-aspartate-L-glutamate (NAAG) to yield glutamate and N-acetylaspartate. The compounds of the present invention include phosphinic acid derivatives that inhibit NAALADase enzyme activity and which have been found useful for inhibiting the growth of prostate cancer cells.

Inventors

  • 👤 Paul F. Jackson
  • 👤 Barbara S. Slusher

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-07 11:32
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/655; C07F9/6552; C07F9/28; C07F9/30; C07F9/301; C07F9/38; C07F9/40; C07F9/4071; C07F9/4075; C07F9/44; C07F9/4461; C07F9/4465; C07F9/553; C07F9/576; C07F9/58; C07F9/65515

Claims Analysis

Total Claims: 12
Claim 1
Independent Claim 255 words
A pharmaceutical composition which comprises: i) an effective amount of a compound having the formula: ##STR8## where R is a C 1 -C 9 straight or branched chain alkyl, C 2 -C 9 straight or branched chain alkenyl group, C 3 -C 8 cycloalkyl, C 5 -C 7 cycloalkenyl, phenyl, 1-napthyl, 2-napthyl, and phenyl (C 1 -C 4 alkyl), wherein said alkyl, alkenyl, cycloalkyl, cycloalkenyl, phenyl, 1-napthyl, 2-napthyl, or phenyl (C 1 -C 4 alkyl) groups are optionally substituted with a substituent selected from the group consisting of: C 3 -C 8 cycloalkyl, C 5 -C 7 cycloalkenyl, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, hydroxy, halo, hydroxyl, nitro, trifluoromethyl, C 1 -C 6 straight or branched chain alkyl or alkenyl, C 1 -C 4 alkoxy, C 2 -C 4 alkenyloxy, phenoxy, benzyloxy, amino, and Ar 1 , where Ar 1 is selected from the group consisting of 1-napthyl, 2-napthyl, and phenyl, and where Ar 1 has one to three substituents which are independently selected from the group consisting of hydrogen, halo, hydroxyl, nitro, trifluoromethyl, C 1 -C 6 straight or branched chain alkyl, C 2 -C 6 straight or branched chain alkenyl, C 1 -C 4 alkoxy or C 2 -C 4 alkenyloxy, phenoxy, benzyloxy, and amino; or a pharmaceutically acceptable salt, hydrate or mixture thereof; ii) an effective amount of an additional therapeutic agent selected from the group consisting of therapeutic hormones, chemotherapeutic agents, monoclonal antibodies, anti-angiogenisis agents, radiolabelled compounds, and a mixture thereof; and (iii) a suitable pharmaceutical carrier.
Claim 2
Dependent Claim 255 words
A pharmaceutical composition which comprises: i) an effective amount of a compound having the formula: ##STR8## where R is a C 1 -C 9 straight or branched chain alkyl, C 2 -C 9 straight or branched chain alkenyl group, C 3 -C 8 cycloalkyl, C 5 -C 7 cycloalkenyl, phenyl, 1-napthyl, 2-napthyl, and phenyl (C 1 -C 4 alkyl), wherein said alkyl, alkenyl, cycloalkyl, cycloalkenyl, phenyl, 1-napthyl, 2-napthyl, or phenyl (C 1 -C 4 alkyl) groups are optionally substituted with a substituent selected from the group consisting of: C 3 -C 8 cycloalkyl, C 5 -C 7 cycloalkenyl, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, hydroxy, halo, hydroxyl, nitro, trifluoromethyl, C 1 -C 6 straight or branched chain alkyl or alkenyl, C 1 -C 4 alkoxy, C 2 -C 4 alkenyloxy, phenoxy, benzyloxy, amino, and Ar 1 , where Ar 1 is selected from the group consisting of 1-napthyl, 2-napthyl, and phenyl, and where Ar 1 has one to three substituents which are independently selected from the group consisting of hydrogen, halo, hydroxyl, nitro, trifluoromethyl, C 1 -C 6 straight or branched chain alkyl, C 2 -C 6 straight or branched chain alkenyl, C 1 -C 4 alkoxy or C 2 -C 4 alkenyloxy, phenoxy, benzyloxy, and amino; or a pharmaceutically acceptable salt, hydrate or mixture thereof; ii) an effective amount of an additional therapeutic agent selected from the group consisting of therapeutic hormones, chemotherapeutic agents, monoclonal antibodies, anti-angiogenisis agents, radiolabelled compounds, and a mixture thereof; and (iii) a suitable pharmaceutical carrier.
Claim 3
Dependent Claim 27 words
A method of inhibiting prostatic adenocarcinoma tumor cell growth which comprises: administering to said tumor cell or cells an effective amount of a composition of claim 1.
Claim 4
Dependent Claim 23 words
A method of inhibiting NAALADase enzyme activity which comprises: administering to said NAALADase enzyme an effective amount of a composition of claim 1.
Claim 5
Dependent Claim 99 words
A pharmaceutical composition comprising: i) a compound selected from the group consisting of: 2- methylhydroxyphosphinyl!methyl!pentanedioic acid; 2- ethylhydroxyphosphinyl!methyl!pentanedioic acid; 2- propylhydroxyphosphinyl!methyl!pentanedioic acid; 2- butylhydroxyphosphinyl!!methyl!pentanedioic acid; 2- cylohexylhydroxyphosphinyl!methyl!pentanedioic acid; 2- phenylhydroxyphosphinyl!!methyl!pentanedioic acid; 2- (phenylmethyl) hydroxyphosphinyl!methyl!pentanedioic acid; 2- ((2-phenylethyl)methyl)hydroxyphosphinyl!methyl!pentanedioic acid; 2- ((3-phenylpropyl)methyl)hydroxyphosphinyl!methyl!pentanedioic acid; 2- ((3-phenylbutyl)methyl)hydroxyphosphinyl!methyl!pentanedioic acid; 2- ((2-phenylbutyl)methyl)hydroxyphosphinyl!methyl!pentanedioic acid; 2- (4-phenylbutyl) hydroxyphosphinyl!methyl!pentanedioic acid; 2- (aminomethyl) hydroxyphosphinyl!!methyl!pentanedioic acid; and a pharmaceutically acceptably salt, hydrate or mixture thereof; ii) an effective amount of an additional therapeutic agent selected from the group consisting of therapeutic hormones, chemotherapeutic agents, monoclonal antibodies, anti-angiogenesis agents, radiolabelled compounds, and a mixture thereof; and (iii) a suitable pharmaceutical carrier.
Claim 6
Dependent Claim 99 words
A pharmaceutical composition comprising: i) a compound selected from the group consisting of: 2- methylhydroxyphosphinyl!methyl!pentanedioic acid; 2- ethylhydroxyphosphinyl!methyl!pentanedioic acid; 2- propylhydroxyphosphinyl!methyl!pentanedioic acid; 2- butylhydroxyphosphinyl!!methyl!pentanedioic acid; 2- cylohexylhydroxyphosphinyl!methyl!pentanedioic acid; 2- phenylhydroxyphosphinyl!!methyl!pentanedioic acid; 2- (phenylmethyl) hydroxyphosphinyl!methyl!pentanedioic acid; 2- ((2-phenylethyl)methyl)hydroxyphosphinyl!methyl!pentanedioic acid; 2- ((3-phenylpropyl)methyl)hydroxyphosphinyl!methyl!pentanedioic acid; 2- ((3-phenylbutyl)methyl)hydroxyphosphinyl!methyl!pentanedioic acid; 2- ((2-phenylbutyl)methyl)hydroxyphosphinyl!methyl!pentanedioic acid; 2- (4-phenylbutyl) hydroxyphosphinyl!methyl!pentanedioic acid; 2- (aminomethyl) hydroxyphosphinyl!!methyl!pentanedioic acid; and a pharmaceutically acceptably salt, hydrate or mixture thereof; ii) an effective amount of an additional therapeutic agent selected from the group consisting of therapeutic hormones, chemotherapeutic agents, monoclonal antibodies, anti-angiogenesis agents, radiolabelled compounds, and a mixture thereof; and (iii) a suitable pharmaceutical carrier.
Claim 7
Dependent Claim 27 words
A method of inhibiting prostatic adenocarcinoma tumor cell growth which comprises: administering to said tumor cell or cells an effective amount of a composition of claim 4.
Claim 8
Dependent Claim 23 words
A method of inhibiting NAALADase enzyme activity which comprises: administering to said NAALADase enzyme an effective amount of a composition of claim 4.
Claim 9
Dependent Claim 73 words
A pharmaceutical composition comprising: i) a compound selected from the group consisting of: 2- methylhydroxyphosphinyl!methylpentanedioic acid; 2- ethylhydroxyphosphinyl!methyl!pentanedioic acid; 2- propylhydroxyphosphinyl!methyl!pentanedioic acid; 2- phenylhydroxyphosphinyl!methyl!pentanedioic acid; 2- phenylmethylhydroxyphosphinyl!methyl!pentanedioic acid; and a pharmaceutically acceptable salt, hydrate or a mixture thereof; ii) an effective amount of an additional therapeutic agent selected from the group consisting of therapeutic hormones, chemotherapeutic agents, monoclonal antibodies, anti-angiogenesis agents, radiolabelled compounds, and a mixture thereof; and (iii) a suitable pharmaceutical carrier.
Claim 10
Dependent Claim 73 words
A pharmaceutical composition comprising: i) a compound selected from the group consisting of: 2- methylhydroxyphosphinyl!methylpentanedioic acid; 2- ethylhydroxyphosphinyl!methyl!pentanedioic acid; 2- propylhydroxyphosphinyl!methyl!pentanedioic acid; 2- phenylhydroxyphosphinyl!methyl!pentanedioic acid; 2- phenylmethylhydroxyphosphinyl!methyl!pentanedioic acid; and a pharmaceutically acceptable salt, hydrate or a mixture thereof; ii) an effective amount of an additional therapeutic agent selected from the group consisting of therapeutic hormones, chemotherapeutic agents, monoclonal antibodies, anti-angiogenesis agents, radiolabelled compounds, and a mixture thereof; and (iii) a suitable pharmaceutical carrier.
Claim 11
Dependent Claim 27 words
A method of inhibiting prostatic adenocarcinoma tumor cell growth which comprises: administering to said tumor cell or cells an effective amount of a composition of claim 7.
Claim 12
Dependent Claim 23 words
A method of inhibiting NAALADase enzyme activity which comprises: administering to said NAALADase enzyme an effective amount of a composition of claim 7.

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 2002-03-08 2002-09-07 2003-03-09 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2006-03-08 2006-09-07 2007-03-09 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2010-03-08 2010-09-07 2011-03-09 $7700.00 Window Closed / Lapsed

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