US4555506A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Phosphorus containing compounds and use as hypotensives
Assignee: ER Squibb and Sons LLC
•
Filing: 1981-12-24
•
Granted: 1985-11-26
•
Expires: 2001-12-24
Abstract
Abstract Phosphorus containing compounds of the formula ##STR1## wherein X is a substituted or unsubstituted imino or amino acid and A is ##STR2## These compounds possess angiotensin converting enzyme activity and are thus useful as hypertensive agents.
Inventors
- 👤 Donald S. Karanewsky
- 👤 Edward W. Petrillo, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 05:56
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/6561; C07F9/65615; A; A61; A61P; A61P9/00; A61P9/12; C07F9/28; C07F9/30; C07F9/301; C07F9/306; C07F9/32; C07F9/3205; C07F9/3211; C07F9/3241; C07F9/38; C07F9/3804; C07F9/3808; C07F9/3882; C07F9/40; C07F9/4003; C07F9/4006; C07F9/4056; C07F9/44; C07F9/4461; C07F9/4484; C07F9/4492; C07F9/48; C07F9/4808; C07F9/4816; C07F9/553; C07F9/5537; C07F9/568; C07F9/572; C07F9/5728; C07F9/576; C07F9/59; C07F9/62; C07F9/645; C07F9/6503; C07F9/6506; C07F9/6536; C07F9/6539
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
28 words
A compound of the formula ##STR454## wherein R 2 is phenylmethyl; and R 3 and R 6 are the same and each is hydrogen, sodium, potassium, or lithium.
Claim 2
Dependent Claim
28 words
A compound of the formula ##STR454## wherein R 2 is phenylmethyl; and R 3 and R 6 are the same and each is hydrogen, sodium, potassium, or lithium.
Claim 3
Dependent Claim
8 words
The compound of claim 1, (S)-1-[[[2-(benzoylamino)-3-phenylpropyl]hydroxyphosphinyl]acetyl]-L-proline, dilithium salt.
Claim 4
Dependent Claim
39 words
A composition useful for treating hypertension comprising a pharmaceutically acceptable carrier and a hypotensive agent or pharmaceutically acceptable salt thereof of the formula ##STR455## wherein R 2 , R 3 and R 6 are as defined in claim 1.
Claim 5
Dependent Claim
21 words
The method of alleviating hypertension in a mammalian specie which comprises administering an effective amount of the composition of claim 3.
Claim 6
Dependent Claim
28 words
A compound of the formula ##STR456## wherein R 2 is phenylethyl; and R 3 and R 6 are the same and each is hydrogen, sodium, potassium or lithium.
Claim 7
Dependent Claim
28 words
A compound of the formula ##STR456## wherein R 2 is phenylethyl; and R 3 and R 6 are the same and each is hydrogen, sodium, potassium or lithium.
Claim 8
Dependent Claim
39 words
A composition useful for treating hypertension comprising a pharmaceutically acceptable carrier and a hypotensive agent or pharmaceutically acceptable salt thereof of the formula ##STR457## wherein R 2 , R 3 and R 6 are as defined in claim 5.
Claim 9
Dependent Claim
21 words
The method of alleviating hypertension in a mammaliam specie which comprises administering an effective amount of the composition of claim 6.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-11-25 | 1989-05-27 | 1989-11-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-11-25 | 1993-05-27 | 1993-11-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-11-25 | 1997-05-27 | 1997-11-26 | $7700.00 | Window Closed / Lapsed |