US4468519A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Esters of phosphinylalkanoyl substituted prolines
Assignee: ER Squibb and Sons LLC
•
Filing: 1982-06-14
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Granted: 1984-08-28
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Expires: 2002-06-14
Abstract
Abstract Hypotensive activity is exhibited by compounds having the formula ##STR1## and salts thereof wherein R 1 is alkyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl; R 2 is cycloalkyl, 3-cyclohexenyl or 2-alkyl-3-cyclohexenyl; R 3 is alkyl, cycloalkyl, phenyl or alkoxy; R 4 is hydrogen or alkyl; one of R 5 and R 6 is hydrogen and the other is alkyl-X-, phenyl-X-, alkoxy, phenyloxy, phenyl, cycloalkyl, alkyl, or phenylalkyl; or together R 5 and R 6 are --XCH 2 CH 2 X--; R 7 is hydrogen or ##STR2## and n is 0 or 1.
Inventors
- 👤 John Krapcho
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 08:18
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/6561; A; A61; A61P; A61P9/00; A61P9/12; C07F9/28; C07F9/30; C07F9/32; C07F9/3258; C07F9/3264; C07F9/553; C07F9/572; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
93 words
A compound having the formula ##STR55## or a salt thereof, wherein R 1 is alkyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl; R 2 is cycloalkyl, 3-cyclohexenyl, or 2-alkyl-3-cyclohexenyl; R 3 is alkyl, cycloalkyl, phenyl or alkoxy; R 4 is hydrogen or alkyl; one of R 5 and R 6 is hydrogen and the other is alkyl-X-, phenyl-X-, alkoxy, phenyloxy, phenyl, cycloalkyl, alkyl, or phenylalkyl; or together R 5 and R 6 are --XCH 2 CH 2 X--; and X is --S--, ##STR56## R 7 is hydrogen or ##STR57## and n is 0 or 1.
Claim 2
Dependent Claim
93 words
A compound having the formula ##STR55## or a salt thereof, wherein R 1 is alkyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl; R 2 is cycloalkyl, 3-cyclohexenyl, or 2-alkyl-3-cyclohexenyl; R 3 is alkyl, cycloalkyl, phenyl or alkoxy; R 4 is hydrogen or alkyl; one of R 5 and R 6 is hydrogen and the other is alkyl-X-, phenyl-X-, alkoxy, phenyloxy, phenyl, cycloalkyl, alkyl, or phenylalkyl; or together R 5 and R 6 are --XCH 2 CH 2 X--; and X is --S--, ##STR56## R 7 is hydrogen or ##STR57## and n is 0 or 1.
Claim 3
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 2 is cycloalkyl.
Claim 4
Dependent Claim
14 words
A compound in accordance with claim 1 wherein R 2 is 3-cyclohexenyl or 2-alkyl-3-cyclohexenyl.
Claim 5
Dependent Claim
12 words
A compound in accordance with claim 2 wherein R 1 is 4-phenylbutyl.
Claim 6
Dependent Claim
12 words
A compound in accordance with claim 2 wherein R 4 is hydrogen.
Claim 7
Dependent Claim
12 words
A compound in accordance with claim 2 wherein R 7 is hydrogen.
Claim 8
Dependent Claim
11 words
A compound in accordance with claim 2 wherein n is 0.
Claim 9
Dependent Claim
28 words
A compound in accordance with claim 1 wherein R 1 is 4-phenylbutyl, R 2 is cyclohexyl, R 4 is hydrogen, R 7 is hydrogen and n is 0.
Claim 10
Dependent Claim
13 words
The compound in accordance with claim 1, (S)-7-[[[cyclohexyl(1-oxopropoxy)methoxy](4-phenylbutyl)phosphinyl]acetyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid, or a salt thereof.
References Cited (Backward Citations)
US4105776A
Cited
US4316906A
Cited
US4168267A
Cited
US4311697A
Cited
US4316905A
Cited
US4337201A
Cited
US4374131A
Cited
US4381297A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-08-28 | 1988-02-27 | 1988-08-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-08-28 | 1992-02-27 | 1992-08-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-08-28 | 1996-02-27 | 1996-08-28 | $7700.00 | Window Closed / Lapsed |