US5698402A
Expired / Lapsed
US
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Methods for diagnosing benign prostatic hyperplasia
Assignee: Dianon Systems Inc
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Filing: 1995-02-23
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Granted: 1997-12-16
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Expires: 2015-02-23
Abstract
Abstract The present invention relates to a method for diagnosing benign prostatic hyperplasia (BPH) in a male human patient without requiring a biopsy. The total prostate specific antigen (PSA) level in the blood or serum of the patient is measured. If the patient has a total PSA level of between 2.5 ng/ml, (4.0 ng/ml for those 60 years or over), and 10.0 ng/ml, then the free PSA level in the blood or serum of the patient is measured. The proportion of free PSA to total PSA is calculated. If this proportion is equal to or greater than about 25%, then the patient is diagnosed as having BPH.
Inventors
- 👤 Albert A. Luderer
- 👤 Grant D. Carlson
- 👤 Robert P. Thiel
- 👤 Thomas F. Soriano
- 👤 William J. Kramp
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 11:34
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/68; G01N33/53; G01N33/575; G01N33/57555
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
106 words
A method for diagnosing benign prostatic hyperplasia (BPH) in a male human patient under 60 years old without requiring a prostate biopsy comprising: a) measuring the total prostate specific antigen (PSA) level in the blood or serum of the patient; b) measuring the free PSA level in the blood or serum of a patient only if said patient has a total PSA level of between 2.5 ng/ml and 10.0 ng/ml; c) calculating the proportion of free PSA to total PSA; and d) diagnosing the patient as having BPH if the calculated proportion of free PSA to total PSA is equal to or greater than about 25%.
Claim 2
Independent Claim
106 words
A method for diagnosing benign prostatic hyperplasia (BPH) in a male human patient under 60 years old without requiring a prostate biopsy comprising: a) measuring the total prostate specific antigen (PSA) level in the blood or serum of the patient; b) measuring the free PSA level in the blood or serum of a patient only if said patient has a total PSA level of between 2.5 ng/ml and 10.0 ng/ml; c) calculating the proportion of free PSA to total PSA; and d) diagnosing the patient as having BPH if the calculated proportion of free PSA to total PSA is equal to or greater than about 25%.
Claim 3
Independent Claim
107 words
A method for diagnosing benign prostatic hyperplasia (BPH) in a male human patient at least 60 years old without requiring a prostate biopsy comprising: a) measuring the total prostate specific antigen (PSA) level in the blood or serum of the patient; b) measuring the free PSA level in the blood or serum of a patient only if said patient has a total PSA level of between 4.0 ng/ml and 10.0 ng/ml; c) calculating the proportion of free PSA to total PSA; and d) diagnosing the patient as having BPH if the calculated proportion of free PSA to total PSA is equal to or greater than about 25%.
Claim 4
Independent Claim
107 words
A method for diagnosing benign prostatic hyperplasia (BPH) in a male human patient at least 60 years old without requiring a prostate biopsy comprising: a) measuring the total prostate specific antigen (PSA) level in the blood or serum of the patient; b) measuring the free PSA level in the blood or serum of a patient only if said patient has a total PSA level of between 4.0 ng/ml and 10.0 ng/ml; c) calculating the proportion of free PSA to total PSA; and d) diagnosing the patient as having BPH if the calculated proportion of free PSA to total PSA is equal to or greater than about 25%.
References Cited (Backward Citations)
US5501983A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-12-15 | 2001-06-16 | 2001-12-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-12-15 | 2005-06-16 | 2005-12-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-12-15 | 2009-06-16 | 2009-12-16 | $7700.00 | Window Closed / Lapsed |