Phosphorus containing compounds and hypotensive use thereof

Claim 1

A compound of the formula ##STR463## and a pharmaceutically acceptable salt thereof wherein: R 1 and R 2 are independently selected from the group consisting of hydrogen, lower alkyl, halo substituted lower alkyl, ##STR464## and amino substituted lower alkyl; q is zero or an integer from 1 to 7; R 23 is hydrogen, lower alkyl, halo substituted lower alkyl, ##STR465## R 7 is hydrogen, lower alkyl, halogen, keto, hydroxy, ##STR466## a 1- or 2-naphthyl of the formula ##STR467## a 1- or 2-naphthyloxy of the formula ##STR468## or a 1- or 2-naphthylthio of the formula ##STR469## R 8 is keto, halogen, ##STR470## --O--lower alkyl, a 1- or 2-naphthyloxy of the formula ##STR471## or a 1- or 2-naphthylthio of the formula ##STR472## R 9 is keto or ##STR473## R 10 is halogen or --Y--R 16 ; R 13 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy or 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, chloro, bromo, fluoro, trifluoromethy;, hydroxy, phenyl, phenoxy, phenylthio, or phenylmethyl; R 14 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, chloro, bromo, fluoro, trifluoromethyl, or hydroxy; m is zero, one, two or three; p is one, two or three provided that p is more than one only if R 13 or R 14 is hydrogen, methyl, methoxy, chloro or fluoro; R 15 is hydrogen or lower alkyl of 1 to 4 carbons; Y is oxygen or sulfur; R 16 is lower alkyl of 1 to 4 carbons or ##STR474## r is an integer from 1 to 4; R 3 and R 6 are independently selected from the group consisting of hydrogen, lower alkyl, benzyl, benzhydryl, and ##STR475## wherein R 17 is hydrogen, lower alkyl, or phenyl, and R 18 is hydrogen, lower alkyl, lower alkoxy, phenyl, or R 17 and R 18 taken together are --(CH 2 ) 2 --, --(CH 2 ) 3 --, --CH═CH--, or ##STR476## R 19 is lower alkyl, benzyl, or phenethyl; and R 20 is hydrogen, lower alkyl, benzyl or phenethyl.