Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive

Claim 1

A compound of the formula ##STR293## and pharmceutically acceptable salts thereof wherein: ##STR294## R 1 is alkyl of 1 to 10 carbons, amino substituted lower alkyl, halo substituted lower alkyl, ##STR295## --(CH 2 ) q -cycloalkyl containing 3 to 7 carbons in the cycloalkyl portion, ##STR296## wherein q is zero or an interger from 1 to 7: R 11 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alklthio of 1 to 4 carbons, chloro, bromo, fluoro, trifluoromethyl, hydroxy, phenyl, phenoxy, phenylthio, or phenylmethyl; p is one, two or three provided that p is more than one only if R 11 is hydrogen, methyl, methoxy, chloro, or fluoro; R 19 and R 20 are independently selected from the group consisting of hydrogen, lower alkyl, halo substituted lower alkyl, ##STR297## --(CH 2 ) m -cycloalkyl containing 3 to 7 carbons in the cycloalkyl portion ##STR298## m is zero, one, two or three, wherein R 11 and p are as defined above; R 2 is hydrogen, lower alkyl, halo substituted lower alkyl, ##STR299## --(CH 2 ) r --NH 2 , --(CH 2 ) r --S--lower alkyl, ##STR300## wherein r is an integer from 1 to 4; R 3 and R 6 are independently selected from hydrogen, lower alkyl, benzyl, benzhydryl, alkali metal or ##STR301## wherein R 15 is hydrogen, lower alkyl, cycloalkyl containing 3 to 7 carbons, or phenyl, and R 16 is hydrogen, lower alkyl, lower alkoxy, phenyl, or R 15 and R 16 taken together are --(CH 2 ) 2 --, --(CH 2 ) 3 , --CH═CH--or ##STR302##