Phosphinylalkanoyl substituted imino acids and their use in hypotensive compositions

Claim 1

A compound of the formula ##STR66## and a pharmaceutically acceptable salt thereof wherein X is ##STR67## R 1 is straight or branched chain alkyl of 1 to 10 carbons, halo substituted lower alkyl wherein lower alkyl is straight or branched chain of 1 to 7 carbons, cycloalkyl-(CH 2 ) m -- wherein cycloalkyl is a saturated ring of 3 to 7 carbon atoms, ##STR68## R 2 is hydrogen, straight or branched chain lower alkyl of 1 to 7 carbons, halo substituted lower alkyl wherein lower alkyl is straight or branched chain of 1 to 7 carbons, benzyl, or phenethyl; R 3 and R 4 are independently selected from the group consisting of hydrogen, straight or branched chain lower alkyl of 1 to 7 carbons, benzyl, benzhydryl, and ##STR69## wherein R 6 is hydrogen, straight or branched chain alkyl of 1 to 10 carbons, cycloalkyl which is a saturated ring of 3 to 7 carbon atoms, or phenyl, and R 7 is hydrogen, straight or branched chain alkyl of 1 to 10 carbons, cycloalkyl which is a saturated ring of 3 to 7 carbon atoms, lower alkoxy of 1 to 7 carbons, phenyl, benzyl, phenethyl, or R 6 and R 7 taken together are --(CH 2 ) 2 --, --(CH 2 ) 3 --, --CH═CH--, or ##STR70## n is zero to one; m is zero or an integer from 1 to 7; R 5 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, chloro, bromo, fluoro, trifluoromethyl, or hydroxy; and p is one, two or three provided that p is more than one only if R 5 is hydrogen, methyl, methoxy, chloro, or fluoro.