Phosphinylmethylaminocarbonyl imino acid compounds useful for treating hypertension

Claim 1

A compound of the formula ##STR185## and pharmaceutically acceptable salts thereof wherein: X is an imino acid of the formula ##STR186## R 1 is hydrogen, lower alkyl, halo substituted lower alkyl, amino substituted lower alkyl, benzyl, or phenethyl; R 2 and R 4 are independently selected from the group consisting of hydrogen, lower alkyl, benzyl, benzhydryl, and ##STR187## wherein R 17 is hydrogen, alkyl, cycloalkyl, or phenyl, and R 18 is hydrogen, alkyl, cycloalkyl, phenyl, benzyl, phenethyl, or R 17 and R 18 taken together are --(CH 2 ) 2 --, --(CH 2 ) 3 --, --CH═CH--, or ##STR188## and R 3 is alkyl, halo substituted lower alkyl, amino substituted lower alkyl, cycloalkyl--(CH 2 ) n --, ##STR189## R 13 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, chloro, bromo, fluoro, trifluoromethyl, hydroxy, phenyl, phenoxy, phenylthio, or benzyl; p is one, two or three provided that p is more than one only if R 13 is hydrogen, methyl, methoxy, chloro, or fluoro; and n is zero or an integer from 1 to 7.