Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension

Claim 1

A compound of the formula ##STR147## wherein X is an imino acid of the formula ##STR148## R 3 is hydrogen, lower alkyl, halogen, keto, hydroxy, ##STR149## azido, amino, ##STR150## a 1- or 2-naphthyl of the formula ##STR151## --(CH 2 ) m -cycloalkyl, ##STR152## --O--lower alkyl, ##STR153## a 1- or 2-naphthyloxy of the formula ##STR154## --S--lower alkyl, ##STR155## or a 1- or 2-naphthylthio of the formula ##STR156## R 4 is keto, halogen, ##STR157## --O--lower alkyl, a 1- or 2-naphthyloxy of the formula ##STR158## --S--lower alkyl, ##STR159## or a 1- or 2-naphthylthio of the formula ##STR160## R 5 is keto or ##STR161## R 7 is halogen or --Y--R 13 ; R 10 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, chloro, bromo, fluoro, trifluoromethyl, hydroxy, phenyl, phenoxy, phenylthio, or phenylmethyl; R 11 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, chloro, bromo, fluoro, trifluoromethyl, or hydroxy; m is zero, one, two or three; p is one, two or three provided that p is more than one only if R 10 or R 11 is hydrogen, methyl, methoxy, chloro, or fluoro; R 12 is hydrogen or lower alkyl of 1 to 4 carbons; Y is oxygen or sulfur; R 13 is lower alkyl of 1 to 4 carbons, ##STR162## or the R 13 groups join to complete an unsubstituted 5- or 6-membered ring or said ring in which one or more of the carbons has a lower alkyl of 1 to 4 carbons or a di(lower alkyl of 1 to 4 carbons) substituent; n is an integer of from 4 to 8; n' is zero or one; R 2 is hydrogen, lower alkyl, halo substituted lower alkyl, benzyl or phenethyl; R 1 and R 6 are independently selected from hydrogen, lower alkyl, benzyl, benzhydryl, or ##STR163## wherein R 14 is hydrogen, lower alkyl, cycloalkyl or phenyl, and R 15 is hydrogen, lower alkyl, lower alkoxy, phenyl, or R 14 and R 15 taken together are --(CH 2 ) 2 --, --(CH 2 ) 3 --, --CH═CH--, or ##STR164## and when either or both of R 1 and R 6 are hydrogen a basic addition salt or an amino acid addition salt thereof.