US5030732A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Aminoethylphosphinic acid derivatives
Assignee: Merck and Co Inc
•
Filing: 1988-03-03
•
Granted: 1991-07-09
•
Expires: 2008-03-03
Abstract
Abstract Disclosed are some new aminoethylphosphinic acid derivatives useful as antibacterial agents.
Inventors
- 👤 Yoshiharu Morita
- 👤 Yasuo Hoshide
- 👤 Ryoichi Ando
- 👤 Masao Taniguchi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 08:04
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06191; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/30; C07F9/301; A; A61; A61K; A61K38/00; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
50 words
A compound represented by Formula I, ##STR13## in which X is hydrogen, acyl or amino acid Y is hydrogen, unsubstituted or substituted alkylacyl wherein said alkyl substitutent is selected from the group consisting of amino, alkoxy and hydroxy; amino acid and R 1 and R 2 is hydrogen or alkyl.
Claim 2
Dependent Claim
50 words
A compound represented by Formula I, ##STR13## in which X is hydrogen, acyl or amino acid Y is hydrogen, unsubstituted or substituted alkylacyl wherein said alkyl substitutent is selected from the group consisting of amino, alkoxy and hydroxy; amino acid and R 1 and R 2 is hydrogen or alkyl.
Claim 3
Dependent Claim
36 words
The compound according to claim 1 in which the structure is represented by Formula III, ##STR14## in which R 1 is hydrogen or alkyl, R 4 is alkyl or benzylthioalkyl, and R 5 is amino acid.
Claim 4
Dependent Claim
34 words
The compound according to claim 2, in which R 1 in Formula III is hydrogen, R 4 is n-propyl or benzylthiomethyl, and R 5 is alanyl, phenylalanyl, leucyl, isoleucyl, norvalyl, sarcosyl, sarcosylalanyl or alanylalanyl.
Claim 5
Dependent Claim
27 words
A compound represented by Formula I: ##STR15## in which R 1 is hydrogen or alkyl, and R 6 is an amino acid residue with or without protection.
Claim 6
Dependent Claim
27 words
A compound represented by Formula I: ##STR15## in which R 1 is hydrogen or alkyl, and R 6 is an amino acid residue with or without protection.
Claim 7
Dependent Claim
23 words
The compound according to claim 4 in which R 1 is hydrogen and R 6 is lysyl, seryl, alanyl, norvalyl, o-benzylseryl, or S-benzylcysteine.
Claim 8
Dependent Claim
25 words
The compound according to claim 1 being: (1-aminoethyl) (2-amino-2-carboxyethyl)phosphinic acid; (1-aminoethyl) (2-L-norvalylamino-2-carboxyethyl) phosphinic acid; (1-aminoethyl) (2-L-methionylamino-2-carboxyethyl) phosphinic acid; (1-aminoethyl) (2-L-alanyl-L-norvalylamino-2-carboxyethyl)phosphinic acid; or (1-aminoethyl) (2-L-norvalyl-L-norvalylamino-2-carboxyethyl)phosphinic acid.
References Cited (Backward Citations)
US4147780A
Cited
US4160452A
Cited
US4256108A
Cited
US4265874A
Cited
US4539208A
Cited
US4374131A
Cited
US4416833A
Cited
EP0091594A1
Cited
EP0161546A1
Cited
EP0209848A2
Cited
EP0210545A2
Cited
US4715994A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-07-08 | 1995-01-07 | 1995-07-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-07-08 | 1999-01-07 | 1999-07-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-07-08 | 2003-01-07 | 2003-07-09 | $7700.00 | Window Closed / Lapsed |