Combination of thienamycin-type antibiotics with dipeptidase inhibitors

Claim 1

An antibacterial composition comprising a combination of thienamycin-type compound of the formula ##STR73## wherein X is CH 2 or S; R 2 is H; --S--C 1 --C 6 alkyl; --S--(CH 2 ) 2 --NHR 3 wherein R 3 is H, acetyl, formimidoyl, or acetimidoyl; --S(O)--CH═CHNHCOCH 3 ; or --S--CH═CHNHCOCH 3 and R 6 is H or ##STR74## wherein R 7 is H, OH or sulfonyloxy and a dipeptidase (3.C.3.413.11) inhibitor compound of the following formula ##STR75## wherein R 2 and R 3 are hydrocarbon radicals in the range respectively of 3-10 and 1-15 carbon atoms; in either one of these R 2 or R 3 hydrocarbon chains 1-6 hydrogens may be replaced by halogens or a nonterminal methylene may be replaced by oxygen or sulfur, including oxidized forms of the latter; additionally, a terminal hydrogen in R 3 can also be replaced by hydroxyl or thiol, which may be acylated or carbamoylated; or the hydrogen can be replaced by amino, which may be derivatized as in an acylamino, ureido, amidino, guanidino, or alkyl or substituted alkyl amino group, including quaternary nitrogen groupings; or, there may be replacement by acid groups such as carboxylic, phosphonic or sulfonic acid groups or esters or amides thereof, or cyano; or combinations thereof, such as a terminal amino acid grouping; and R 1 is hydrogen or lower alkyl (C 1-6 ) or dialkylaminoalkyl, or a pharmaceutically acceptable cation, the ratio of the thienamycin-type compound to the dipeptidase inhibitor being within the range of about 1:3 to about 30:1.