US4416833A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Substituted carbonyl phosphinyl-alkanoyl compounds
Assignee: ER Squibb and Sons LLC
•
Filing: 1982-11-26
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Granted: 1983-11-22
•
Expires: 2002-11-26
Abstract
Abstract Compounds of the formula ##STR1## wherein X is an imino acid or ester are disclosed as useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.
Inventors
- 👤 Donald S. Karanewsky
- 👤 Edward W. Petrillo, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 06:44
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/6536; C07F9/6539; C07F9/553; C07F9/572; C07F9/6561; C07F9/65615
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
143 words
A compound of the formula ##STR253## wherein n is zero or one; R 5 is hydrogen, lower alkyl, halo substituted lower alkyl, benzyl, or phenethyl; R 3 is hydrogen, lower alkyl, benzyl, or benzhydryl; R 4 is hydrogen, lower alkyl, halo substituted lower alkyl, ##STR254## R 1 and R 2 are independently selected from the group consisting of hydrogen, lower alkyl, halo substituted lower alkyl, ##STR255## R 13 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, chloro, bromo, fluoro, trifluoromethyl, hydroxy, phenyl, phenoxy, phenylthio, or phenylmethyl; q is zero or an integer from 1 to 7; m is zero, one, two or three; and p is one, two or three provided that p is more than one only if R 13 is hydrogen, methyl, methoxy, chloro, or fluoro.
Claim 2
Dependent Claim
143 words
A compound of the formula ##STR253## wherein n is zero or one; R 5 is hydrogen, lower alkyl, halo substituted lower alkyl, benzyl, or phenethyl; R 3 is hydrogen, lower alkyl, benzyl, or benzhydryl; R 4 is hydrogen, lower alkyl, halo substituted lower alkyl, ##STR254## R 1 and R 2 are independently selected from the group consisting of hydrogen, lower alkyl, halo substituted lower alkyl, ##STR255## R 13 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, chloro, bromo, fluoro, trifluoromethyl, hydroxy, phenyl, phenoxy, phenylthio, or phenylmethyl; q is zero or an integer from 1 to 7; m is zero, one, two or three; and p is one, two or three provided that p is more than one only if R 13 is hydrogen, methyl, methoxy, chloro, or fluoro.
Claim 3
Dependent Claim
18 words
A compound of claim 1 wherein n is zero; R 2 is hydrogen; and R 5 is hydrogen.
Claim 4
Dependent Claim
64 words
A compound of claim 2 wherein R 4 is lower alkyl of 1 to 7 carbons, trifluoromethyl, ##STR256## cyclopentyl, cyclohexyl, ##STR257## R 3 is hydrogen, lower alkyl, or benzyl; R 1 is lower alkyl of 1 to 7 carbons, or ##STR258## q is zero or an integer from 1 to 4; and R 13 is hydrogen, methyl, methoxy, methylthio, chloro, bromo, fluoro, or hydroxy.
Claim 5
Dependent Claim
23 words
The compound of claim 3 wherein R 4 is phenyl; R 1 is ##STR259## and R 3 is --C 2 H 5 .
Claim 6
Dependent Claim
29 words
The compound of claim 3 wherein R 4 is phenyl; R 1 is --(CH 2 ) 5 --CH 3 ; and R 3 is --C 2 H 5 .
Claim 7
Dependent Claim
29 words
The compound of claim 3 wherein R 4 is --(CH 2 ) 4 --CH 3 ; R 1 is ##STR260## and R 3 is --C 2 H 5 .
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-11-21 | 1987-05-23 | 1987-11-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-11-21 | 1991-05-23 | 1991-11-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-11-21 | 1995-05-23 | 1995-11-22 | $7700.00 | Window Closed / Lapsed |