Patent US4416833A successfully refreshed from Google Patents.
← Back to Patent Explorer
US4416833A Expired / Lapsed US ⏱️ 0.0 years remaining

Substituted carbonyl phosphinyl-alkanoyl compounds

Assignee: ER Squibb and Sons LLC
•
Filing: 1982-11-26
•
Granted: 1983-11-22
•
Expires: 2002-11-26
📄 Original PDF 🌐 Google Patents 🔄 Sync Now

Abstract

Abstract Compounds of the formula ##STR1## wherein X is an imino acid or ester are disclosed as useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.

Inventors

  • 👤 Donald S. Karanewsky
  • 👤 Edward W. Petrillo, Jr.

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-07 07:00
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/6536; C07F9/6539; C07F9/553; C07F9/572; C07F9/6561; C07F9/65615

Claims Analysis

Total Claims: 7
Claim 1
Independent Claim 143 words
A compound of the formula ##STR253## wherein n is zero or one; R 5 is hydrogen, lower alkyl, halo substituted lower alkyl, benzyl, or phenethyl; R 3 is hydrogen, lower alkyl, benzyl, or benzhydryl; R 4 is hydrogen, lower alkyl, halo substituted lower alkyl, ##STR254## R 1 and R 2 are independently selected from the group consisting of hydrogen, lower alkyl, halo substituted lower alkyl, ##STR255## R 13 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, chloro, bromo, fluoro, trifluoromethyl, hydroxy, phenyl, phenoxy, phenylthio, or phenylmethyl; q is zero or an integer from 1 to 7; m is zero, one, two or three; and p is one, two or three provided that p is more than one only if R 13 is hydrogen, methyl, methoxy, chloro, or fluoro.
Claim 2
Dependent Claim 143 words
A compound of the formula ##STR253## wherein n is zero or one; R 5 is hydrogen, lower alkyl, halo substituted lower alkyl, benzyl, or phenethyl; R 3 is hydrogen, lower alkyl, benzyl, or benzhydryl; R 4 is hydrogen, lower alkyl, halo substituted lower alkyl, ##STR254## R 1 and R 2 are independently selected from the group consisting of hydrogen, lower alkyl, halo substituted lower alkyl, ##STR255## R 13 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, chloro, bromo, fluoro, trifluoromethyl, hydroxy, phenyl, phenoxy, phenylthio, or phenylmethyl; q is zero or an integer from 1 to 7; m is zero, one, two or three; and p is one, two or three provided that p is more than one only if R 13 is hydrogen, methyl, methoxy, chloro, or fluoro.
Claim 3
Dependent Claim 18 words
A compound of claim 1 wherein n is zero; R 2 is hydrogen; and R 5 is hydrogen.
Claim 4
Dependent Claim 64 words
A compound of claim 2 wherein R 4 is lower alkyl of 1 to 7 carbons, trifluoromethyl, ##STR256## cyclopentyl, cyclohexyl, ##STR257## R 3 is hydrogen, lower alkyl, or benzyl; R 1 is lower alkyl of 1 to 7 carbons, or ##STR258## q is zero or an integer from 1 to 4; and R 13 is hydrogen, methyl, methoxy, methylthio, chloro, bromo, fluoro, or hydroxy.
Claim 5
Dependent Claim 23 words
The compound of claim 3 wherein R 4 is phenyl; R 1 is ##STR259## and R 3 is --C 2 H 5 .
Claim 6
Dependent Claim 29 words
The compound of claim 3 wherein R 4 is phenyl; R 1 is --(CH 2 ) 5 --CH 3 ; and R 3 is --C 2 H 5 .
Claim 7
Dependent Claim 29 words
The compound of claim 3 wherein R 4 is --(CH 2 ) 4 --CH 3 ; R 1 is ##STR260## and R 3 is --C 2 H 5 .

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1986-11-21 1987-05-23 1987-11-22 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1990-11-21 1991-05-23 1991-11-22 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1994-11-21 1995-05-23 1995-11-22 $7700.00 Window Closed / Lapsed

Assigned Categories & Tags

No categories assigned to this patent yet.

Assign Category Tag