US5075109A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of potentiating an immune response
Assignee: UAB Research Foundation
•
Filing: 1988-03-18
•
Granted: 1991-12-24
•
Expires: 2008-03-18
Abstract
Abstract A method of delivering a bioactive agent to an animal entailing the steps of encapsulating effective amounts of the agent in a biocompatible excipient to form microcapsules having a size ranging from between approximately one micrometer to approximately ten micrometers and admnistering effective amounts of the microcapsules to the animal. A pulsatile response is obtained, as well as mucosal and systemic immuity. Related compositions are also provided.
Inventors
- 👤 Thomas R. Tice
- 👤 Richard M. Gilley
- 👤 John H. Eldridge
- 👤 Jay K. Staas
- 👤 Melinda G. Hollingshead
- 👤 William M. Shannon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 05:54
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K31/215; A61K31/216; A61K9/00; A61K9/48; A61K9/50; A61K39/00; A61K39/02; A61K39/085; A61K39/12; A61K39/39; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1635; A61K9/1641; A61K9/1647; A61P; A61P37/00; A61P37/02; A61P37/04; A61K2039/54; A61K2039/541; A61K2039/545; A61K2039/555; A61K2039/55511; A61K2039/55555; A61K38/00; C; C12; C12N; C12N2770/00; C12N2770/00011; C12N2770/24011; C12N2770/24111; C12N2770/24134; Y; Y02; Y02A; Y02A50/00; Y02A50/30; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984; Y10T428/2985; Y10T428/2989
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
97 words
A method of potentiating the immune response of an animal, comprising the step of parenterally administering to said animal a mixture of effective amounts of first biocompatible microcapsules having a size between approximately 1 micrometer and approximately 10 micrometers and containing a bioactive agent adn second biocompatible microcapsules containing a bioactive agent, said first microcapsules providing a primary immunological response and said second microcapsules releasing said agent contained in said second microcapsules ina pulsed manner to potentiate a subsequent immunological response, wherein said bioactive agent is selected from the group consisting of an antigen and an allergen.
Claim 2
Independent Claim
97 words
A method of potentiating the immune response of an animal, comprising the step of parenterally administering to said animal a mixture of effective amounts of first biocompatible microcapsules having a size between approximately 1 micrometer and approximately 10 micrometers and containing a bioactive agent adn second biocompatible microcapsules containing a bioactive agent, said first microcapsules providing a primary immunological response and said second microcapsules releasing said agent contained in said second microcapsules ina pulsed manner to potentiate a subsequent immunological response, wherein said bioactive agent is selected from the group consisting of an antigen and an allergen.
Claim 3
Dependent Claim
17 words
The method of claim 1, wherein said second biocompatible microcapsules have a size greater than 10 micrometers.
References Cited (Backward Citations)
US2738303A
Cited
US3823228A
Cited
US4021364A
Cited
FR2287216A1
Cited
US4269821A
Cited
US4291016A
Cited
US4123519A
Cited
US4209507A
Cited
US4166800A
Cited
US4152415A
Cited
US4203968A
Cited
US4152414A
Cited
US4152413A
Cited
US4732763A
Cited
US4585651A
Cited
US4309406A
Cited
US4309405A
Cited
US4298002A
Cited
US4292298A
Cited
US4367217A
Cited
US4439199A
Cited
US4384975A
Cited
US4455142A
Cited
US4590170A
Cited
US4650769A
Cited
US4326524A
Cited
US4389330A
Cited
US4349530A
Cited
US4524060A
Cited
US4681752A
Cited
US4783336A
Cited
US4428926A
Cited
US4428925A
Cited
US4479911A
Cited
US4434153A
Cited
US4484923A
Cited
US4526938A
Cited
US4559303A
Cited
US4542025A
Cited
US4530840A
Cited
US4525339A
Cited
US4613500A
Cited
US4690682A
Cited
EP0126537A2
Cited
EP0130162A2
Cited
AU3108884A
Cited
GB2160312A
Cited
US4764359A
Cited
US4610870A
Cited
WO1987006129A1
Cited
WO1988001213A1
Cited
US4925673A
Cited
WO1988009163A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-12-23 | 1995-06-24 | 1995-12-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-12-23 | 1999-06-24 | 1999-12-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-12-23 | 2003-06-24 | 2003-12-24 | $7700.00 | Window Closed / Lapsed |