US4326524A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Solid dose ballistic projectile
Assignee: 3M Co
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Filing: 1980-09-30
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Granted: 1982-04-27
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Expires: 2000-09-30
Abstract
Abstract A solid dose ballistic projectile formed entirely of a cohesive mixture comprising biologically active material, in the form of grindable solid particles having an average diameter between about 7 and 25 micrometers, and biologically inert binder, and capable of withstanding the stresses imparted thereon when the projectile is propelled ballistically from a barrel and implanted in the flesh of a living animal.
Inventors
- 👤 James F. Drake, Jr.
- 👤 G. Phillip Rambosek
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 17:26
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61D; A61D7/00; A61M; A61M37/00; F; F42; F42B; F42B12/00; F42B12/02; F42B12/36; F42B12/46; F42B12/54
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
162 words
A solid dose ballistic projectile shaped for penetrating the epidermal layer of a living animal and lodging totally within the tissues of the animal and capable of releasing biologically active ingredient into said tissue of said animal when lodged therein, the projectile comprising in a major portion a body consisting essentially of a uniform cohesive mixture of from about 70 to 95 weight percent of grindable solid particles, at least about 90 weight percent of said particles having an average diameter between about 7 and 25 micrometers, and at least a biologically effective amount of said particles comprising biologically active material, and from about 5 to 30 weight percent of a biologically inert, cohesive binder adhered to said particles, said binder being more compressible than said grindable solid particles, and said body being capable of providing structural integrity to said projectile when ballistically propelled at a muzzle velocity of up to about 475 m/sec and implanted within said tissues of said animal.
Claim 2
Dependent Claim
162 words
A solid dose ballistic projectile shaped for penetrating the epidermal layer of a living animal and lodging totally within the tissues of the animal and capable of releasing biologically active ingredient into said tissue of said animal when lodged therein, the projectile comprising in a major portion a body consisting essentially of a uniform cohesive mixture of from about 70 to 95 weight percent of grindable solid particles, at least about 90 weight percent of said particles having an average diameter between about 7 and 25 micrometers, and at least a biologically effective amount of said particles comprising biologically active material, and from about 5 to 30 weight percent of a biologically inert, cohesive binder adhered to said particles, said binder being more compressible than said grindable solid particles, and said body being capable of providing structural integrity to said projectile when ballistically propelled at a muzzle velocity of up to about 475 m/sec and implanted within said tissues of said animal.
Claim 3
Dependent Claim
23 words
The solid dose ballistic projectile of claim 1 wherein said grindable solid particles comprise 100 percent by weight of said biologically active material.
Claim 4
Dependent Claim
32 words
The solid dose ballistic projectile of claim 1 wherein said biologically active material is selected from the group consisting of vaccines, bacterins, hormones, minerals, vitamins, antibiotics, antigens, anthelmintics, medicinal drugs, and tranquilizers.
Claim 5
Dependent Claim
28 words
The solid dose ballistic projectile of claim 1 wherein said biologically active material is a crystalline medicament selected from the group consisting of penicillins, tetracycline HCl, and erythromycin.
Claim 6
Dependent Claim
36 words
The solid dose ballistic projectile of claim 1 wherein said biologically inert binder is selected from the group consisting of hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, sodium carboxymethyl cellulose, polyvinyl alcohol, polyvinyl pyrrolidene, gum arabic, polylactic acids and polyamides.
Claim 7
Dependent Claim
26 words
The solid dose ballistic projectile of claim 1 wherein said grindable solid particles also comprise adjuvants selected from the group consisting of lubricants, disintegrants, and fillers.
Claim 8
Dependent Claim
27 words
The solid dose ballistic projectile of claim 6 wherein said adjuvant is a lubricant selected from the group consisting of talc, magnesium stearate, calcium stearate, and carbowax.
Claim 9
Dependent Claim
24 words
The solid dose ballistic projectile of claim 7 wherein said lubricant comprises up to about 5 percent by weight of said uniform cohesive mixture.
Claim 10
Dependent Claim
27 words
The solid dose ballistic projectile of claim 6 wherein said adjuvant is a disintegrant selected from the group consisting of hydroxypropyl starch, calcium alginate and sodium alginate.
Claim 11
Dependent Claim
27 words
The solid dose ballistic projectile of claim 6 wherein said adjuvant is a filler selected from the group consisting of sodium chloride, calcium carbonate, and crystalline lactose.
Claim 12
Dependent Claim
23 words
The solid dose ballistic projectile of claim 10 wherein said filler comprises up to about 30 percent by weight of said solid particles.
Claim 13
Dependent Claim
60 words
A method of manufacturing the solid dose ballistic projectile of claim 1 comprising compressing in a pill press said uniform cohesive mixture of said grindable solid particles, and said binder, said uniform cohesive mixture comprising said solid particles coated with a thin layer of said binder, said binder coated solid particles having an average diameter of less than 50 micrometers.
Claim 14
Dependent Claim
22 words
The method of claim 12 wherein said binder coating is applied to said grindable solid particles by spray or freeze drying techniques.
Claim 15
Dependent Claim
55 words
A ballistic projectile according to claim 1 wherein said projectile has an elongated body portion with a central axis, adapted for close fitting engagement with the inner surface of a barrel from which said projectile is to be propelled, and a generally conical nose portion with and projecting from one end of said body portion.
Claim 16
Dependent Claim
22 words
The ballistic projectile of claim 14 wherein the end of said body portion opposite said nose portion has a concave surface portion.
Claim 17
Dependent Claim
39 words
The ballistic projectile of claim 14 wherein said nose portion has a base diameter smaller than the diameter of said body portion so as to provide a slight shoulder where said base of said nose meets said body portion.
Claim 18
Dependent Claim
23 words
The ballistic projectile of claim 14 wherein said body portion has a cavity therein, said cavity capable of containing additional biologically active material.
Claim 19
Dependent Claim
38 words
A ballistic projectile according to claim 14 wherein said body portion has flatted surface portions of equal width around the periphery of said body portion, said flatted surface portions being evenly twisted about the axis of said tablet.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-04-26 | 1985-10-26 | 1986-04-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-04-26 | 1989-10-26 | 1990-04-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-04-26 | 1993-10-26 | 1994-04-27 | $7700.00 | Window Closed / Lapsed |