US4152415A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of increasing the effectiveness of oral vaccination for swine dysentery
Assignee: Chromalloy American Corp
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Filing: 1978-08-18
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Granted: 1979-05-01
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Expires: 1998-08-18
Abstract
Abstract The resistance of field-raised swine to dysentery infection is increased by a sequence of parenteral and oral administrations. First there is parenterally administered to the swine an injectable cell concentrate containing a virulent isolate of killed cells of Treponema hyodysenteriae, and not less than five days after the animals have received the first of the parenteral injections, a series of oral administrations of enteric-coated pellets is started, the pellets containing concentrated killed cells of a virulent isolate of T. hyodysenteriae. The oral administrations are given at least once every 24 hours for a period of at least five days.
Inventors
- 👤 Delbert L. Harris
- 👤 Robert A. Goodnow
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 22:51
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/02; A61K39/0225; Y; Y10; Y10S; Y10S424/00; Y10S424/825
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
147 words
The method of increasing the resistance of field-raised swine to dysentery infection, comprising a sequence of parenteral and oral administrations which are carried out before the swine contract the infection, characterized by: (a) first parenterally administering to the swine an injectable cell concentrate containing a virulent isolate of killed cells of Treponema hyodysenteriae at least one injection being given per animal and each injection containing at least 2 milligrams (dry basis) of said cells; and (b) not less than 5 days after said animals have received the first of said parenteral injections beginning a series of oral administrations of enteric-coated pellets containing concentrated killed cells of a virulent isolate of Treponema hyodysenteriae, said oral administrations being given at least one every 24 hours for a period of at least 5 days, and each of said oral administrations providing at least 3 milligrams (dry basis) of said cells.
Claim 2
Independent Claim
147 words
The method of increasing the resistance of field-raised swine to dysentery infection, comprising a sequence of parenteral and oral administrations which are carried out before the swine contract the infection, characterized by: (a) first parenterally administering to the swine an injectable cell concentrate containing a virulent isolate of killed cells of Treponema hyodysenteriae at least one injection being given per animal and each injection containing at least 2 milligrams (dry basis) of said cells; and (b) not less than 5 days after said animals have received the first of said parenteral injections beginning a series of oral administrations of enteric-coated pellets containing concentrated killed cells of a virulent isolate of Treponema hyodysenteriae, said oral administrations being given at least one every 24 hours for a period of at least 5 days, and each of said oral administrations providing at least 3 milligrams (dry basis) of said cells.
Claim 3
Dependent Claim
21 words
The method of claim 1 in which said killed cells of Treponema hyodysenteriae are prepared from isolate B204 (ATCC No. 31287).
Claim 4
Dependent Claim
52 words
The method of claim 1 or claim 2 in which said parenteral injections comprise 2 injections per animal with an interval of at least 4 days between the days on which the injections are given, and each parenteral injection provides at least 3 milligrams (dry basis) of said cells of Treponema hyodysenteriae.
Claim 5
Dependent Claim
47 words
The method of claim 1 or claim 2 in which each of said oral administrations provide at least 4 milligrams (dry basis) of said cells per animal and are continued for at least 8 days at the rate of one oral administration per animal per 24 hours.
Claim 6
Dependent Claim
27 words
The method of claim 1 or claim 2 in which said swine are growing pigs, and said oral administrations are started after the pigs have been weaned.
Claim 7
Independent Claim
151 words
The method of increasing the resistance of field-raised swine to dysentery infection, comprising a sequence of parenteral and oral administrations which are carried out before the swine contract the infection, characterized by: (a) first parenterally administering to the swine an injectable cell concentrate containing a virulent isolate of killed cells of Treponema hyodysenteriae, at least two injections being given per animal with an interval of at least 4 days between the days on which the injections are given, and each injection containing at least 2 milligrams (dry basis) of said cells; and (b) not less than 5 days after said animals have received the first of said injections beginning the feeding of enteric-coated granules containing concentrated killed cells of a virulent isolate of Treponema hyodysenteriae, said feeding being at the rate of at least 3 milligrams (dry basis) per animal per 24-hour day, and being continued for at least 5 days.
Claim 8
Independent Claim
151 words
The method of increasing the resistance of field-raised swine to dysentery infection, comprising a sequence of parenteral and oral administrations which are carried out before the swine contract the infection, characterized by: (a) first parenterally administering to the swine an injectable cell concentrate containing a virulent isolate of killed cells of Treponema hyodysenteriae, at least two injections being given per animal with an interval of at least 4 days between the days on which the injections are given, and each injection containing at least 2 milligrams (dry basis) of said cells; and (b) not less than 5 days after said animals have received the first of said injections beginning the feeding of enteric-coated granules containing concentrated killed cells of a virulent isolate of Treponema hyodysenteriae, said feeding being at the rate of at least 3 milligrams (dry basis) per animal per 24-hour day, and being continued for at least 5 days.
Claim 9
Dependent Claim
20 words
The method of claim 6 in which said cell so Treponema hyodysenteriae are prepared from isolate B204 (ATCC No. 31287).
Claim 10
Dependent Claim
16 words
The method of claim 6 or claim 7 in which said parenteral administration is intramuscular injection.
Claim 11
Dependent Claim
44 words
The method of claim 6 or claim 7 in which said swine are baby pigs, and at least the first of said parenteral administrations is given before said pigs are weaned, said feeding of said granules being started after said pigs have been weaned.
Claim 12
Dependent Claim
13 words
The method of claim 9 in which said parenteral administration is intramuscular injection.
References Cited (Backward Citations)
US3127318A
Cited
US2369218A
Cited
US2946724A
Cited
US3072528A
Cited
US3081233A
Cited
US3317393A
Cited
US3458621A
Cited
US3541203A
Cited
US3823228A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-04-30 | 1982-10-30 | 1983-05-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-04-30 | 1986-10-30 | 1987-05-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-04-30 | 1990-10-30 | 1991-05-01 | $7700.00 | Window Closed / Lapsed |