US4439199A
Expired / Lapsed
US
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Method for administering immunopotentiator
Assignee: Alza Corp
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Filing: 1982-03-25
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Granted: 1984-03-27
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Expires: 2002-03-25
Abstract
Abstract The invention pertains to the administration of an immunopotentiator to activate an immune response. The administration comprises the controlled and continuous administration of the immunopotentiator leading to a high immune response with adequate persistancy, while simultaneously and substantially reducing or eliminating inflammatory reactions usually accompanying depot-type administration.
Inventors
- 👤 Alfred A. Amkraut
- 👤 Agusto B. Martins
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 20:15
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0002; A61K9/0004; A61K39/00; A61K39/39
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
103 words
A method for potentiating the immune response of a host, which method consists essentially of administering to a host needing potentiation of the immune response an immunopotentiating agent, said agent administered from a therapeutic delivery system that limits the contact of the host with the agent unitl the agent is released oil-free from the system, thereby lessening the incidence of local inflammation, fever and adverse biological response of the host to the agent, which agent is administered in a therapeutically effective amount of at least one picogram for a prolonged period of time of at least 12 hours for potentiating the immune response.
Claim 2
Independent Claim
103 words
A method for potentiating the immune response of a host, which method consists essentially of administering to a host needing potentiation of the immune response an immunopotentiating agent, said agent administered from a therapeutic delivery system that limits the contact of the host with the agent unitl the agent is released oil-free from the system, thereby lessening the incidence of local inflammation, fever and adverse biological response of the host to the agent, which agent is administered in a therapeutically effective amount of at least one picogram for a prolonged period of time of at least 12 hours for potentiating the immune response.
Claim 3
Dependent Claim
43 words
The method potentiating the immune response of a host according to claim 1, wherein the host is a warm-blooded animal, and the method comprises administering the immunopotentiating agent to the animal to potentiate the immune response of the animal against an impending infection.
Claim 4
Dependent Claim
45 words
The method for potentiating the immune response of a host according to claim 1, wherein the host is a warm-blooded animal, and the method comprises administering the immunopotentiating agent to the animal for potentiating the immune response of the animal against a disease in progress.
Claim 5
Dependent Claim
45 words
The method for potentiating the immune response of a host according to claim 1, wherein the host is an animal, the prolonged period of time corresponds to the period of a threat of an impending infection and the immunopotentiating agent produces a nonspecific immune response.
Claim 6
Dependent Claim
29 words
The method for potentiating the immune response of the host according to claim 1, wherein the prolonged period of time is at least 1 day up to 380 days.
Claim 7
Dependent Claim
20 words
The method for potentiating the immune response of the host according to claim 1, wherein the host is a human.
Claim 8
Dependent Claim
60 words
The method for potentiating the immune response of the host according to claim 1, wherein the host is an animal, the immunopotentiator is nonimmunogenic and mixed with a pharmaceutically acceptable carrier, and the mixture is administered in a prophylactically effective amount at a controlled and continuous rate for up to 180 days to potentiate the immune response against an infection.
Claim 9
Dependent Claim
87 words
The method for potentiating the immune response of the host according to claim 1, wherein the therapeutic delivery system is a matrix and the immunopotentiating agent is housed in the matrix, which matrix is formed of a nontoxic, bioerodible material that bioerodes at a controlled and continuous rate over a prolonged period of at least 1 day up to 180 days, thereby administering the immunopotentiating agent to the host at a controlled and continuous rate over a period of at least 1 day up to 180 days.
Claim 10
Dependent Claim
54 words
The method for potentiating the immune response of the host according to claim 1, wherein the therapeutic delivery system comprises a reservoir, and the immunopotentiating agent is administered at a controlled rate in a therapeutically effective amount for potentiating the immune response from the reservoir of an external therapeutic delivery system to the host.
Claim 11
Dependent Claim
53 words
The method for potentiating the immune response of the host according to claim 1, wherein the therapeutic delivery system is positioned in the host and the method comprises administering a biologically acceptable immunopotentiating agent at a controlled rate and in a therapeutically effective amount for potentiating the immune response from said delivery system.
Claim 12
Dependent Claim
70 words
The method for potentiating the immune response of the host according to claim 1, wherein the therapeutic delivery system is used in a single application and limits contact of the host with the agent until it is administered to the host, and wherein the method comprises the controlled and continuous delivery of the immunopotentiating agent from the system to the host over a prolonged period of 1 to 180 days.
Claim 13
Dependent Claim
54 words
The method for potentiating the immune response of the host according to claim 1, wherein the therapeutic delivery system comprises an internal reservoir and the immunopotentiating agent is housed in the reservoir that limits the agent's contact with the tissues and fluids of the host until the agent is released from the delivery system.
Claim 14
Dependent Claim
24 words
The method for potentiating the immune response of the host according to claim 1, wherein the therapeutic delivery system is an osmotic delivery system.
Claim 15
Dependent Claim
24 words
The method for potentiating the immune response of the host according to claim 1, wherein the therapeutic delivery system is a diffusional delivery system.
Claim 16
Dependent Claim
36 words
The method for potentiating the immune response of the host according to claim 1, wherein the method produces an early appearance of an immune response high enough to protect the host from an immediate threatening infection.
Claim 17
Dependent Claim
39 words
The method for potentiating the immune response of the host according to claim 1, wherein the host is a warm-blooded animal, and the immunopotentiator potentiates the immune response of the gastrointestional tract against a disease that enters the tract.
Claim 18
Dependent Claim
35 words
The method for potentiating the immune response of the host according to claim 1, wherein the host is warm-blooded animal and the therapeutic delivery system administers the immunopotentiating agent intramuscularly to produce the desired effect.
Claim 19
Dependent Claim
36 words
The method for potentiating the immune response of the host according to claim 1, wherein the host is a warm-blooded animal and the therapeutic delivery system administers the immunopotentiating agent subcutaneously to produce the desired effect.
Claim 20
Dependent Claim
36 words
The method for potentiating the immune response of the host according to claim 1, wherein the host is a warm-blooded animal and the therapeutic delivery system administers the immunopotentiating agent parenterally to produce the desired effect.
Claim 21
Dependent Claim
36 words
The method for potentiating the immune response of the host according to claim 1, wherein the host is a warm-blooded animal and the therapeutic delivery system administers the immunopotentiating agent parenterally to produce the desired effect.
Claim 22
Dependent Claim
34 words
The method for potentiating the immune response of the host according to claim 1, wherein the prolonged period of time comprises a period of time prior to exposure of the host to a disease.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-03-27 | 1987-09-26 | 1988-03-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-03-27 | 1991-09-26 | 1992-03-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-03-27 | 1995-09-26 | 1996-03-27 | $7700.00 | Window Closed / Lapsed |