US4292298A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical compositions containing paracetamol
Assignee: Beecham Group PLC
•
Filing: 1980-09-12
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Granted: 1981-09-29
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Expires: 2000-09-12
Abstract
Abstract The acute liver toxicity effects of paracetamol are reduced by co-formulating with sustained release ascorbic acid which produces high liver concentrations of ascorbate anion after oral administration of the co-formulation. A suitable form of sustained release ascorbic acid is prepared by microencapsulation of particles of ascorbic acid in membranes which act as microdialysis cells.
Inventors
- 👤 Adrian F. Davis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 01:34
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5084; A61K31/00; A61K31/33; A61K31/335; A61K31/365; A61K31/375
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
40 words
An analgesic and antipyretic pharmaceutical composition suitable for oral administration, comprising paracetamol, characterised in that the composition further includes a sufficient amount of ascorbic acid in a sustained release form to counteract the potential liver toxicity effects of the paracetamol.
Claim 2
Dependent Claim
40 words
An analgesic and antipyretic pharmaceutical composition suitable for oral administration, comprising paracetamol, characterised in that the composition further includes a sufficient amount of ascorbic acid in a sustained release form to counteract the potential liver toxicity effects of the paracetamol.
Claim 3
Dependent Claim
23 words
A composition according to claim 1, in which the ascorbate anion content is from 30% to 100% by weight of the paracetamol content.
Claim 4
Dependent Claim
28 words
A composition according to claim 1, in which the weight ratio of sustained release ascorbate:paracetamol is capable of producing corresponding liver concentrations of at least 1:8 of ascorbate:paracetamol.
Claim 5
Dependent Claim
10 words
A composition according to claim 1, in unit dosage form.
Claim 6
Dependent Claim
21 words
A composition according to claim 4, containing from 300 mg to 1000 mg of sustained release ascorbic acid per unit dose.
Claim 7
Dependent Claim
18 words
A composition according to claim 5, containing from 250 mg to 1000 mg of paracetamol per unit dose.
Claim 8
Dependent Claim
18 words
A composition according to claim 4, in the form of tablets, pills, capsules, dragees, a powder or syrup.
Claim 9
Dependent Claim
49 words
A composition according to claim 1, in which the sustained release ascorbic acid is in the form of solid ascorbic acid having a water resistant or water permeable coating, or spray dried ascorbic acid, or a hydrophobic matrix having ascorbic acid particles distributed throughout, or enteric coated ascorbic acid.
Claim 10
Dependent Claim
35 words
A treatment pack comprising an oral dosage unit comprising paracetamol and an oral dosage unit comprising sustained release ascorbic acid, the two oral dosage units being retained in the pack in association with one another.
Claim 11
Dependent Claim
35 words
A treatment pack comprising an oral dosage unit comprising paracetamol and an oral dosage unit comprising sustained release ascorbic acid, the two oral dosage units being retained in the pack in association with one another.
Claim 12
Independent Claim
32 words
A method of reducing the potential liver toxicity effect of a pharmaceutical composition comprising paracetamol, in which an effective amount of ascorbic acid in sustained release form is included in the composition.
Claim 13
Independent Claim
32 words
A method of reducing the potential liver toxicity effect of a pharmaceutical composition comprising paracetamol, in which an effective amount of ascorbic acid in sustained release form is included in the composition.
References Cited (Backward Citations)
US2953497A
Cited
DE1292783B
Cited
US3265629A
Cited
US3247065A
Cited
US3446891A
Cited
US3780195A
Cited
FR2081065B1
Cited
US3860733A
Cited
US4036948A
Cited
DE2706705A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-09-28 | 1985-03-30 | 1985-09-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-09-28 | 1989-03-30 | 1989-09-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-09-28 | 1993-03-30 | 1993-09-29 | $7700.00 | Window Closed / Lapsed |