US5776193A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bone grafting matrix
Assignee: DePuy Spine LLC
•
Filing: 1996-04-17
•
Granted: 1998-07-07
•
Expires: 2016-04-17
Abstract
Abstract A porous three-dimensional bone grafting matrix is provided which is biodegradable. The matrix is preferably formed from mineralized collagen where the mineral comprises particulate calcium phosphate immobilized in the matrix and having a particle size of 5 microns or less.
Inventors
- 👤 Michael K. Kwan
- 👤 Stephen D. Pacetti
- 👤 Ronald K. Yamamoto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 22:59
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/001; A61L24/0042; A61F; A61F2/00; A61F2/02; A61F2/28; A61L24/0036; A61L24/0047; A61L24/0073; A61L24/0084; A61L27/00; A61L27/14; A61L27/26; A61L27/40; A61L27/44; A61L27/46; A61L27/50; A61L27/54; A61L27/56; A61P; A61P19/00; A61F2002/2817; A61F2002/2835; A61F2/30; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2002/30092; A61F2002/30108; A61F2002/30199; A61F2002/30667; A61F2002/30677; A61F2210/00; A61F2210/0004; A61F2210/0014; A61F2230/00; A61F2230/0063; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00293; A61F2310/00365; A61F2310/00383; A61L2300/00; A61L2300/20; A61L2300/30; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/412; A61L2300/414; A61L2300/60; A61L2300/602; A61L2300/64; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
75 words
A porous, biodegradable three-dimensionally fixed matrix for the replacement of bone which maintains physical integrity for a period of at least about three days after implant and its porosity for a period of about seven to fourteen days after implant into a physiological environment in which bone replacement is occurring, comprising a bound network of water insoluble mineralized biopolymer fibers and a water insoluble binder, wherein said mineralized biopolymer fibers comprise immobile calcium phosphate mineral.
Claim 2
Dependent Claim
75 words
A porous, biodegradable three-dimensionally fixed matrix for the replacement of bone which maintains physical integrity for a period of at least about three days after implant and its porosity for a period of about seven to fourteen days after implant into a physiological environment in which bone replacement is occurring, comprising a bound network of water insoluble mineralized biopolymer fibers and a water insoluble binder, wherein said mineralized biopolymer fibers comprise immobile calcium phosphate mineral.
Claim 3
Dependent Claim
56 words
A matrix according to claim 1 wherein said binder is selected from the group consisting of soluble collagen, gelatin, polylactic acid, polyglycolic acid, copolymers of lactic and glycolic acid, polycaprolactone, carboxymethylcellulose, cellulose esters, dextrose, dextran, chitosan, hyaluronic acid, ficol, chondroitin sulfate, polyvinyl alcohol, polyacrylic acid, polypropylene glycol, polyethylene glycol, water soluble polyacrylates and water soluble polymethacrylates.
Claim 4
Dependent Claim
13 words
A matrix according to claim 1 wherein said biopolymer fibers comprise fibrillar collagen.
Claim 5
Dependent Claim
11 words
A matrix according to claim 1 wherein said mineral comprises hydroxyapatite.
Claim 6
Dependent Claim
21 words
A matrix according to claim 1 wherein said mineral consists of particles of a diameter no greater than about five microns.
Claim 7
Dependent Claim
39 words
A matrix according to claim 1 wherein said mineral is released as particles into said physiological environment during replacement with bone in a time-release profile which maintains said physical integrity and porosity, respectively for said respective periods of time.
Claim 8
Dependent Claim
17 words
A matrix according to claim 3 wherein said bipolymer fibers comprise about 30-80% by weight of collagen.
Claim 9
Dependent Claim
14 words
A matrix according to any of claims 1 through 7 further comprising marrow cells.
Claim 10
Dependent Claim
14 words
A matrix according to any of claims 1 through 7 further comprising autogenous bone.
Claim 11
Dependent Claim
18 words
A matrix according to any of claims 1 through 7 further comprising one or more bone growth factors.
References Cited (Backward Citations)
GB1271763A
Cited
US4294753A
Cited
US4455256A
Cited
US4440750A
Cited
US4434094A
Cited
US4789663A
Cited
US4627982A
Cited
US4563350A
Cited
US4888366A
Cited
US4795467A
Cited
US4698326A
Cited
US4780450A
Cited
US5133755A
Cited
US4962091A
Cited
US5306311A
Cited
WO1989004646A1
Cited
US4863732A
Cited
WO1990001955A1
Cited
US5328955A
Cited
US5264214A
Cited
US5092883A
Cited
WO1990010018A1
Cited
US5314474A
Cited
US5294446A
Cited
US5236456A
Cited
WO1993005823A1
Cited
WO1993005808A1
Cited
WO1991018558A1
Cited
US5397770A
Cited
US5231169A
Cited
US5393739A
Cited
US5208219A
Cited
US5413989A
Cited
US5376636A
Cited
WO1992020371A1
Cited
US5338772A
Cited
WO1993004710A2
Cited
US5306303A
Cited
US5532217A
Cited
WO1994000145A1
Cited
WO1994015653A1
Cited
WO1995008304A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-07-06 | 2002-01-05 | 2002-07-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-07-06 | 2006-01-05 | 2006-07-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-07-06 | 2010-01-05 | 2010-07-07 | $7700.00 | Window Closed / Lapsed |