US5306311A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Prosthetic articular cartilage
Assignee: Regen Corp
•
Filing: 1991-12-17
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Granted: 1994-04-26
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Expires: 2011-12-17
Abstract
Abstract A prosthetic, resorbable articular cartilage and methods of its fabrication and insertion are disclosed. The prosthetic articular cartilage, when implanted in a humanoid joint, acts as a resorbable scaffold for ingrowth of native articular chondrocytes and supports natural articulating joint forces. The prosthetic articular cartilage is a dry, porous, volume matrix of biocompatible and bioresorbable fibers. These fibers include a natural polymer or analogs thereof, at least a portion of which may be crosslinked. The matrix is adapted to have an in vivo outer surface contour substantially the same as that of natural articular cartilage in an articulating joint, and has a pore size in the approximate range of about 100 microns to about 400 microns.
Inventors
- 👤 Kevin R. Stone
- 👤 Shu-Tung Li
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:54
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/58; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2/30; A61F2/30756; A61F2/38; A61F2/3872; A61F2/44; A61F2/442; A61L27/14; A61L27/20; A61L27/22; A61L27/227; A61L27/24; A61L27/26; A61L27/40; A61L27/44; A61L27/46; A61L27/48; A61L27/56; C; C08; C08L; C08L1/00; A61F2/30767; A61F2/30907; A61F2/3094; A61F2/30965; A61F2002/30001; A61F2002/30003; A61F2002/30004; A61F2002/30006; A61F2002/3006; A61F2002/30062; A61F2002/30108; A61F2002/3011; A61F2002/30112; A61F2002/30113; A61F2002/30131; A61F2002/30199; A61F2002/30205; A61F2002/30224; A61F2002/30225; A61F2002/3023; A61F2002/30667; A61F2002/30677; A61F2/30721; A61F2/30734; A61F2002/30736; A61F2002/30766; A61F2/30771; A61F2002/30795; A61F2002/30807; A61F2002/30808; A61F2002/3082; A61F2002/30822; A61F2002/30827; A61F2002/30878; A61F2002/30879; A61F2002/30881; A61F2002/30891; A61F2002/30904; A61F2/30942; A61F2002/30957; A61F2/42; A61F2/4261; A61F2002/4271; A61F2002/4274; A61F2002/4276; A61F2002/4279; A61F2002/4282; A61F2002/4284; A61F2002/4287; A61F2002/4289; A61F2002/4292; A61F2002/4294; A61F2002/4297; A61F2210/00; A61F2210/0004; A61F2230/00; A61F2230/0002; A61F2230/0004; A61F2230/0006; A61F2230/0013; A61F2230/0063; A61F2230/0067; A61F2230/0069; A61F2250/00; A61F2250/0014; A61F2250/0015; A61F2250/0057; A61F2310/00; A61F2310/00005; A61F2310/00365; A61L2430/00; A61L2430/06; A61L2430/38
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
94 words
A prosthetic articular cartilage device comprising a dry porous volume matrix of biocompatible and at least partially bioresorbable fibers, said fibers selected from the group consisting of natural polymers, and analogs and mixtures thereof, said matrix being adapted to have an in vivo outer surface contour substantially the same as that of natural articular cartilage, said matrix having a pore size in the approximate range of about 100 microns to about 400 microns, whereby said matrix establishes a bioresorbable scaffold adapted for the ingrowth of articular chondrocytes, and for supporting natural articulating joint forces.
Claim 2
Dependent Claim
94 words
A prosthetic articular cartilage device comprising a dry porous volume matrix of biocompatible and at least partially bioresorbable fibers, said fibers selected from the group consisting of natural polymers, and analogs and mixtures thereof, said matrix being adapted to have an in vivo outer surface contour substantially the same as that of natural articular cartilage, said matrix having a pore size in the approximate range of about 100 microns to about 400 microns, whereby said matrix establishes a bioresorbable scaffold adapted for the ingrowth of articular chondrocytes, and for supporting natural articulating joint forces.
Claim 3
Dependent Claim
19 words
The prosthetic articular cartilage device of claim 1 further comprising crosslinks between at least a portion of said fibers.
Claim 4
Dependent Claim
19 words
The prosthetic articular cartilage device of claim 1 further comprising a plurality of polysaccharide molecules interspersed with said fibers.
Claim 5
Dependent Claim
23 words
The prosthetic articular cartilage device of claim 3 wherein at least a portion of said molecules provide crosslinks between ones of said fibers.
Claim 6
Dependent Claim
25 words
The prosthetic articular cartilage device of claim 1 wherein said fibers are selected from the group consisting of collagen, elastin, reticulin, cellulose, and mixtures thereof.
Claim 7
Dependent Claim
41 words
The prosthetic articular cartilage device of claim 3 wherein said fibers are present at a concentration of about 75 to 100% by dry weight, and said polysaccharide molecules are present at a concentration of about 0 to 25% by dry weight.
Claim 8
Dependent Claim
38 words
The prosthetic articular cartilage device of claim 3, wherein said polysaccharide molecules are selected from the group consisting of chondroitin 4-sulfate, chondroitin 6-sulfate, keratan sulfate, dermatan sulfate, heparan sulfate, heparin, hyaluronic acid, alginic acid, chitosan, and mixtures thereof.
Claim 9
Dependent Claim
16 words
The prosthetic articular cartilage device of claim 1, wherein said cartilage before implantation is a cylinder.
Claim 10
Dependent Claim
18 words
The prosthetic articular cartilage device of claim 2 wherein said crosslinks are formed by a chemical crosslinking agent.
Claim 11
Dependent Claim
35 words
The prosthetic articular cartilage device of claim 9 wherein said crosslinking agent is selected from the group consisting of glutaraldehyde, formaldehyde, biocompatible bifunctional aldehydes, carbodiimides, hexamethylene diisocyanate, bis-imidates, polyglycerol polyglycidyl ether, glyoxal, and mixtures thereof.
Claim 12
Dependent Claim
24 words
The prosthetic articular cartilage device of claim 3 wherein said cartilage has a density of about 0.07 to 0.50 gram matrix per cubic centimeter.
Claim 13
Dependent Claim
27 words
The prosthetic articular cartilage device of claim 3 wherein said cartilage has an intrafibrillary and interfibrillary space of about 2 to 14 cubic centimeters per gram matrix.
Claim 14
Dependent Claim
21 words
The prosthetic articular cartilage device of claim 1 wherein said fibers are oriented in a substantially random fashion throughout said matrix.
Claim 15
Dependent Claim
21 words
The prosthetic articular cartilage device of claim 1 wherein said fibers are oriented in a substantially ordered fashion throughout said matrix.
Claim 16
Dependent Claim
16 words
The Prosthetic articular cartilage device of claim 14 wherein said matrix comprises substantially circumferentially extending fibers.
Claim 17
Dependent Claim
16 words
The prosthetic articular cartilage device of claim 14 wherein said matrix comprises substantially radially extending fibers.
Claim 18
Dependent Claim
20 words
The prosthetic articular cartilage device of claim 1 wherein the density of said fibers is substantially uniform throughout said matrix.
Claim 19
Dependent Claim
19 words
The prosthetic articular cartilage device of claim 3 wherein said polysaccharide molecules are dispersed substantially uniformly throughout said matrix.
Claim 20
Dependent Claim
18 words
The prosthetic articular cartilage device of claim 3 wherein said polysaccharide molecules are dispersed nonuniformly throughout said matrix.
Claim 21
Dependent Claim
43 words
The prosthetic articular cartilage device of claim 1 further comprising a biocompatible conical base component including means for anchoring said articular cartilage device in a complimentary aperture in cancellous bone, said base component extending from portions of the outer surface of said matrix.
Claim 22
Dependent Claim
17 words
The prosthetic articular cartilage device of claim 20 wherein said base component is at least partially resorbable.
Claim 23
Dependent Claim
19 words
The prosthetic articular cartilage device of claim 20 wherein said base component includes a plurality of circumferentially extending ridges.
Claim 24
Independent Claim
116 words
A method of regenerating articular cartilage in vivo comprising the steps of: (a) providing prosthetic articular cartilage device comprising a dry porous volume matrix of biocompatible and bioresorbable fibers, said fibers selected from the group consisting of natural polymers, and analogs and mixtures thereof, said matrix being adapted to have an in vivo outer surface contour substantially the same as that of natural articular cartilage, and said matrix having a pore size in the approximate range of about 100 microns to about 400 microns; and (b) implanting said prosthetic articular cartilage into a joint by surgical procedures, said matrix establishing a bioresorbable scaffold adapted for ingrowth of articular chondrocytes and for supporting natural articulating joint forces.
Claim 25
Independent Claim
116 words
A method of regenerating articular cartilage in vivo comprising the steps of: (a) providing prosthetic articular cartilage device comprising a dry porous volume matrix of biocompatible and bioresorbable fibers, said fibers selected from the group consisting of natural polymers, and analogs and mixtures thereof, said matrix being adapted to have an in vivo outer surface contour substantially the same as that of natural articular cartilage, and said matrix having a pore size in the approximate range of about 100 microns to about 400 microns; and (b) implanting said prosthetic articular cartilage into a joint by surgical procedures, said matrix establishing a bioresorbable scaffold adapted for ingrowth of articular chondrocytes and for supporting natural articulating joint forces.
Claim 26
Dependent Claim
19 words
The method of claim 23 wherein said providing step includes providing a prosthetic articular cartilage device comprising crosslinked fibers.
Claim 27
Dependent Claim
23 words
The method of claim 23 wherein said providing step further comprises providing a prosthetic articular cartilage device including a plurality of polysaccharide molecules.
Claim 28
Dependent Claim
48 words
The method of claim 23 wherein said providing step further comprises providing a dry porous volume matrix further including a biocompatible conical base component for anchoring said matrix in a complementary aperture in cancellous bone, said base component extending from portions of the outer surface of said matrix.
Claim 29
Dependent Claim
27 words
The method of claim 26 wherein said providing step further comprises providing a dry porous volume matrix including a base component that is at least partially bioresorbable.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-04-25 | 1997-10-25 | 1998-04-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-04-25 | 2001-10-25 | 2002-04-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-04-25 | 2005-10-25 | 2006-04-26 | $7700.00 | Window Closed / Lapsed |