US5116374A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Prosthetic meniscus
Assignee: Regen Corp
•
Filing: 1990-09-13
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Granted: 1992-05-26
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Expires: 2010-09-13
Abstract
Abstract A prosthetic, resorbable meniscus and method of its fabrication are disclosed. The prosthetic meniscus can be implanted in a human knee where it can act as a scaffold for regrowth of native meniscal tissues. The meniscus comprises a dry, porous, matrix of biocompatible and bioresorbable fibers, at least a portion of which may be crosslinked. The fibers include natural polymers or analogs or mixtures thereof. The matrix is adapted to have in vivo an outer surface contour substantially the same as that of a natural meniscus. The matrix has pore size in the approximate range of greater than 50 microns to less than about 500 microns. With this configuration, the matrix establishes an at least partially bioresorbable scaffold adapted for ingrowth of meniscal fibrochondrocytes.
Inventors
- 👤 Kevin R. Stone
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:01
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/38; A61F2/3872; A61F2/28; A61F2/3094; A61F2/30965; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2002/30108; A61F2002/3011; A61F2002/30112; A61F2002/30131; A61F2002/30199; A61F2002/30224; A61F2002/3023; A61F2002/30667; A61F2002/30677; A61F2/30721; A61F2/30734; A61F2002/30736; A61F2/30942; A61F2002/30957; A61F2/42; A61F2/4261; A61F2002/4271; A61F2002/4274; A61F2002/4276; A61F2002/4279; A61F2002/4282; A61F2002/4284; A61F2002/4287; A61F2002/4289; A61F2002/4292; A61F2002/4294; A61F2002/4297; A61F2210/00; A61F2210/0004; A61F2230/00; A61F2230/0002; A61F2230/0004; A61F2230/0013; A61F2230/0063; A61F2230/0069; A61F2310/00; A61F2310/00005; A61F2310/00365
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
126 words
A method of regenerating meniscal tissue in vivo comprising the steps of: (a) fabricating a prosthetic menisucs comprising a dry porous matrix of biocompatible and bioresorbable fibers, said fibers selected from the group consisting of natural polymers, and analogs, and mixtures thereof, said matrix being adapted to have in vivo and outer surface contour substantially the same as that of a natural meniscus, said matrix having pore size in the approximate range of greater than 50 microns to less than about 500 microns, whereby said matrix establishes an at least partially bioresorbable scaffold adapted for ingrowth of meniscal fibrochondrocytes, and wherein said scaffold and said ingrown meniscal fibrochondrocytes support natural meniscal load forces; and (b) implanting said prosthetic meniscus into a knee joint by surgical procedure.
Claim 2
Independent Claim
126 words
A method of regenerating meniscal tissue in vivo comprising the steps of: (a) fabricating a prosthetic menisucs comprising a dry porous matrix of biocompatible and bioresorbable fibers, said fibers selected from the group consisting of natural polymers, and analogs, and mixtures thereof, said matrix being adapted to have in vivo and outer surface contour substantially the same as that of a natural meniscus, said matrix having pore size in the approximate range of greater than 50 microns to less than about 500 microns, whereby said matrix establishes an at least partially bioresorbable scaffold adapted for ingrowth of meniscal fibrochondrocytes, and wherein said scaffold and said ingrown meniscal fibrochondrocytes support natural meniscal load forces; and (b) implanting said prosthetic meniscus into a knee joint by surgical procedure.
Claim 3
Dependent Claim
18 words
The method of claim 1 wherein said fabricating step includes crosslinking at least a portion of said fibers.
Claim 4
Dependent Claim
19 words
The method of claim 1 wherein said prosthetic meniscus fabricated in step (a) comprises a plurality of glycosaminoglycan molecules.
Claim 5
Dependent Claim
25 words
The method of claim 1 wherein said prosthetic meniscus fabricated in step (a) assumes the shape of a native meniscus when implanted in step (b).
Claim 6
Dependent Claim
33 words
The method of claim 5 wherein said fabricating step includes fabricating a prosthetic meniscus comprising a mesh extending from portions of the outer surface of said matrix, said mesh being resorbable and biocompatible.
References Cited (Backward Citations)
US3443261A
Cited
US3551560A
Cited
US3855638A
Cited
US4085466A
Cited
US4060081A
Cited
US4280954A
Cited
US4000525A
Cited
US4055862A
Cited
US4064567A
Cited
US4291013A
Cited
US4351069A
Cited
US4385404A
Cited
US4378224A
Cited
US4344193A
Cited
US4400833A
Cited
US4350629A
Cited
US4472840A
Cited
US4502161B1
Cited
US4502161A
Cited
US4418691A
Cited
US4458678A
Cited
US4505266A
Cited
US4542539A
Cited
US4544516A
Cited
US4578079A
Cited
US4589881A
Cited
US4661111A
Cited
US4448718A
Cited
US4614794A
Cited
US4627853A
Cited
EP0277678A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-05-26 | 1995-11-25 | 1996-05-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-05-26 | 1999-11-25 | 2000-05-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-05-26 | 2003-11-25 | 2004-05-26 | $7700.00 | Window Closed / Lapsed |