Patent US4788967A successfully refreshed from Google Patents.
Patent US5116374A successfully refreshed from Google Patents.
US5116374A
Expired / Lapsed
US
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Prosthetic meniscus
Assignee: Regen Corp
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Filing: 1990-09-13
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Granted: 1992-05-26
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Expires: 2010-09-13
Abstract
Abstract A prosthetic, resorbable meniscus and method of its fabrication are disclosed. The prosthetic meniscus can be implanted in a human knee where it can act as a scaffold for regrowth of native meniscal tissues. The meniscus comprises a dry, porous, matrix of biocompatible and bioresorbable fibers, at least a portion of which may be crosslinked. The fibers include natural polymers or analogs or mixtures thereof. The matrix is adapted to have in vivo an outer surface contour substantially the same as that of a natural meniscus. The matrix has pore size in the approximate range of greater than 50 microns to less than about 500 microns. With this configuration, the matrix establishes an at least partially bioresorbable scaffold adapted for ingrowth of meniscal fibrochondrocytes.
Inventors
- 👤 Kevin R. Stone
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:08
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/38; A61F2/3872; A61F2/28; A61F2/3094; A61F2/30965; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2002/30108; A61F2002/3011; A61F2002/30112; A61F2002/30131; A61F2002/30199; A61F2002/30224; A61F2002/3023; A61F2002/30667; A61F2002/30677; A61F2/30721; A61F2/30734; A61F2002/30736; A61F2/30942; A61F2002/30957; A61F2/42; A61F2/4261; A61F2002/4271; A61F2002/4274; A61F2002/4276; A61F2002/4279; A61F2002/4282; A61F2002/4284; A61F2002/4287; A61F2002/4289; A61F2002/4292; A61F2002/4294; A61F2002/4297; A61F2210/00; A61F2210/0004; A61F2230/00; A61F2230/0002; A61F2230/0004; A61F2230/0013; A61F2230/0063; A61F2230/0069; A61F2310/00; A61F2310/00005; A61F2310/00365
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
126 words
A method of regenerating meniscal tissue in vivo comprising the steps of: (a) fabricating a prosthetic menisucs comprising a dry porous matrix of biocompatible and bioresorbable fibers, said fibers selected from the group consisting of natural polymers, and analogs, and mixtures thereof, said matrix being adapted to have in vivo and outer surface contour substantially the same as that of a natural meniscus, said matrix having pore size in the approximate range of greater than 50 microns to less than about 500 microns, whereby said matrix establishes an at least partially bioresorbable scaffold adapted for ingrowth of meniscal fibrochondrocytes, and wherein said scaffold and said ingrown meniscal fibrochondrocytes support natural meniscal load forces; and (b) implanting said prosthetic meniscus into a knee joint by surgical procedure.
Claim 2
Independent Claim
126 words
A method of regenerating meniscal tissue in vivo comprising the steps of: (a) fabricating a prosthetic menisucs comprising a dry porous matrix of biocompatible and bioresorbable fibers, said fibers selected from the group consisting of natural polymers, and analogs, and mixtures thereof, said matrix being adapted to have in vivo and outer surface contour substantially the same as that of a natural meniscus, said matrix having pore size in the approximate range of greater than 50 microns to less than about 500 microns, whereby said matrix establishes an at least partially bioresorbable scaffold adapted for ingrowth of meniscal fibrochondrocytes, and wherein said scaffold and said ingrown meniscal fibrochondrocytes support natural meniscal load forces; and (b) implanting said prosthetic meniscus into a knee joint by surgical procedure.
Claim 3
Dependent Claim
18 words
The method of claim 1 wherein said fabricating step includes crosslinking at least a portion of said fibers.
Claim 4
Dependent Claim
19 words
The method of claim 1 wherein said prosthetic meniscus fabricated in step (a) comprises a plurality of glycosaminoglycan molecules.
Claim 5
Dependent Claim
25 words
The method of claim 1 wherein said prosthetic meniscus fabricated in step (a) assumes the shape of a native meniscus when implanted in step (b).
Claim 6
Dependent Claim
33 words
The method of claim 5 wherein said fabricating step includes fabricating a prosthetic meniscus comprising a mesh extending from portions of the outer surface of said matrix, said mesh being resorbable and biocompatible.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-05-26 | 1995-11-25 | 1996-05-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-05-26 | 1999-11-25 | 2000-05-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-05-26 | 2003-11-25 | 2004-05-26 | $7700.00 | Window Closed / Lapsed |