US5376636A
Expired / Lapsed
US
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Method for promoting tissue repair and regeneration using PDGF and glucocorticoids
Assignee: CONNECTICUT A CORP OF CT, University of
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Filing: 1992-03-12
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Granted: 1994-12-27
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Expires: 2012-03-12
Abstract
Abstract Disclosed is a method for the regeneration of tissue, the treatment of external wounds and the treatment of periodontal disease comprising applying to the affected tissue an effective amount of a composition comprised of platelet-derived growth factor (PDGF) and an anti-inflammatory compound. The presence of the anti-inflammatory compound potentiates the activity of PDGF in stimulating cell growth, thereby enhancing tissue regeneration and/or wound healing.
Inventors
- 👤 Robert B. Rutherford
- 👤 Marc F. Charette
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 23:45
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/18; A61K38/1858; A61P; A61P1/00; A61P1/02; A61P43/00
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
55 words
A method for promoting regeneration or repair of a tissue in a mammal comprising: applying to the tissue a regenerating amount of a composition comprising PDGF in a concentration of from about 0.1 μg/ml to about 10 mg/ml and a glucocorticoid in a concentration of from about 10 -5 M to about 10 -12 M.
Claim 2
Independent Claim
55 words
A method for promoting regeneration or repair of a tissue in a mammal comprising: applying to the tissue a regenerating amount of a composition comprising PDGF in a concentration of from about 0.1 μg/ml to about 10 mg/ml and a glucocorticoid in a concentration of from about 10 -5 M to about 10 -12 M.
Claim 3
Independent Claim
57 words
A method of regenerating or repairing dental tissue in a mammal comprising the steps of: applying to said dental tissue a regenerating amount of a composition comprising PDGF in a concentration of from about 0.1 μg/ml to about 10 mg/ml and a glucocorticoid in a concentration of from about 10 -5 M to about 10 -12 M.
Claim 4
Independent Claim
57 words
A method of regenerating or repairing dental tissue in a mammal comprising the steps of: applying to said dental tissue a regenerating amount of a composition comprising PDGF in a concentration of from about 0.1 μg/ml to about 10 mg/ml and a glucocorticoid in a concentration of from about 10 -5 M to about 10 -12 M.
Claim 5
Independent Claim
12 words
The method of claims 1 or 2 wherein the tissue comprises epithelium.
Claim 6
Independent Claim
14 words
The method of claims 1 or 2 wherein the tissue comprises bone or cartilage.
Claim 7
Independent Claim
16 words
The method of claims 1 or 2 wherein the composition further comprises a pharmaceutically acceptable carrier.
Claim 8
Independent Claim
21 words
The method of claims 1 or 2 wherein the glucocorticoid is selected from the group consisting of dexamethasone, cortisone and hydrocortisone.
Claim 9
Dependent Claim
40 words
A composition for promoting regeneration or repair of a tissue in a mammal comprising PDGF in a concentration of 0.1 μg/ml to 10 mg/ml and a glucocorticoid compound in a concentration of 10 -5 M to about 10 -12 M.
Claim 10
Dependent Claim
40 words
A composition for promoting regeneration or repair of a tissue in a mammal comprising PDGF in a concentration of 0.1 μg/ml to 10 mg/ml and a glucocorticoid compound in a concentration of 10 -5 M to about 10 -12 M.
Claim 11
Dependent Claim
38 words
A composition for regenerating or repairing dental tissue in a mammal comprising PDGF in a concentration of 0.1 μg/ml to 10 mg/ml and a glucocorticoid compound in a concentration of 10 -5 M to about 10 -12 M.
Claim 12
Dependent Claim
38 words
A composition for regenerating or repairing dental tissue in a mammal comprising PDGF in a concentration of 0.1 μg/ml to 10 mg/ml and a glucocorticoid compound in a concentration of 10 -5 M to about 10 -12 M.
Claim 13
Dependent Claim
21 words
The composition of claim 7 or 8 wherein the glucocorticoid is selected from the group consisting of dexamethasone, cortisone and hydrocortisone.
Claim 14
Dependent Claim
24 words
The composition of claims 7 or 8 further comprising a growth factor in a growth factor:PDGF ratio of from about 1:4 to about 25:1.
Claim 15
Dependent Claim
23 words
The composition of claim 10 wherein the growth factor is selected from the group consisting of transforming growth factor-α and insulin-like growth factors.
Claim 16
Dependent Claim
16 words
The composition of claims 7 or 8 wherein the composition further comprises a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-12-26 | 1998-06-27 | 1998-12-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-12-26 | 2002-06-27 | 2002-12-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-12-26 | 2006-06-27 | 2006-12-27 | $7700.00 | Window Closed / Lapsed |