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US5637698A Expired / Lapsed US ⏱️ 0.0 years remaining

Fused multiple ring lactams

Assignee: Bristol Myers Squibb Co
•
Filing: 1996-02-26
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Granted: 1997-06-10
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Expires: 2016-02-26
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Abstract

Abstract Compounds of the formula ##STR1## are useful as intermediates in the preparation of compounds possessing ACE and NEP inhibition activity.

Inventors

  • 👤 Jeffrey A. Robl

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-05 23:50
CPC Classifications
C; C07; C07D; C07D403/00; C07D403/02; C07D403/06; A; A61; A61P; A61P43/00; A61P9/00; A61P9/12; C07D409/00; C07D409/02; C07D409/06; C07D471/00; C07D471/12; C07D471/14; C07D495/00; C07D495/12; C07D495/14; C07K; C07K5/00; C07K5/02; C07K5/022; C07K5/0222; C07K5/04; C07K5/06; C07K5/06139; A61K; A61K38/00

Claims Analysis

Total Claims: 6
Claim 1
Independent Claim 261 words
A compound of the formula ##STR61## wherein m is one or two; R 3 is hydrogen, alkyl, substituted alkyl, aryl-(CH 2 ) p -, or substituted aryl-(CH 2 ) p -; p is zero or an integer from 1 to 6; ##STR62## represents an aromatic heteroatom containing ring selected from the group consisting of ##STR63## X 1 is S or NH; X 2 is S, O, or NH; and R 13 is hydrogen, lower alkyl, lower alkoxy, lower alkylthio, chloro, bromo, fluoro, trifluoro-methyl, amino, --NH(lower alkyl), --N(lower alkyl) 2 , or hydroxy; the term "alkyl" refers to straight or branched chain radicals of one to seven carbon atoms; the term "substituted alkyl" refers to such straight or branched chain radicals of 1 to 7 carbons wherein one or more hydrogens have been replaced by a hydroxy, amino, halo, trifluoromethyl, cyano, --NH(lower alkyl), --N(lower alkyl) 2 , lower alkoxy, lower alkylthio, or carboxy; the term "aryl" refers to phenyl, 1-naphthyl, and 2-naphthyl; the term "substituted aryl" refers to phenyl, 1-naphthyl, and 2-naphthyl having a substituent selected from lower alkyl, lower alkoxy, lower alkylthio, halo, hydroxy, trifluoromethyl, amino, --NH(lower alkyl), and --N(lower alkyl) 2 , and di- and tri-substituted phenyl, 1-naphthyl, and 2-naphthyl wherein said substituents are selected from methyl, methoxy, methylthio, halo, hydroxy, and amino; the term "lower alkyl" refers to straight or branched radicals of 1 to 4 carbons; the terms "lower alkoxy" and "lower alkylthio" refer to such lower alkyl groups as defined above attached to an oxygen sulfur; and the term "halo" refers to chloro, bromo, fluoro, and iodo.
Claim 2
Dependent Claim 261 words
A compound of the formula ##STR61## wherein m is one or two; R 3 is hydrogen, alkyl, substituted alkyl, aryl-(CH 2 ) p -, or substituted aryl-(CH 2 ) p -; p is zero or an integer from 1 to 6; ##STR62## represents an aromatic heteroatom containing ring selected from the group consisting of ##STR63## X 1 is S or NH; X 2 is S, O, or NH; and R 13 is hydrogen, lower alkyl, lower alkoxy, lower alkylthio, chloro, bromo, fluoro, trifluoro-methyl, amino, --NH(lower alkyl), --N(lower alkyl) 2 , or hydroxy; the term "alkyl" refers to straight or branched chain radicals of one to seven carbon atoms; the term "substituted alkyl" refers to such straight or branched chain radicals of 1 to 7 carbons wherein one or more hydrogens have been replaced by a hydroxy, amino, halo, trifluoromethyl, cyano, --NH(lower alkyl), --N(lower alkyl) 2 , lower alkoxy, lower alkylthio, or carboxy; the term "aryl" refers to phenyl, 1-naphthyl, and 2-naphthyl; the term "substituted aryl" refers to phenyl, 1-naphthyl, and 2-naphthyl having a substituent selected from lower alkyl, lower alkoxy, lower alkylthio, halo, hydroxy, trifluoromethyl, amino, --NH(lower alkyl), and --N(lower alkyl) 2 , and di- and tri-substituted phenyl, 1-naphthyl, and 2-naphthyl wherein said substituents are selected from methyl, methoxy, methylthio, halo, hydroxy, and amino; the term "lower alkyl" refers to straight or branched radicals of 1 to 4 carbons; the terms "lower alkoxy" and "lower alkylthio" refer to such lower alkyl groups as defined above attached to an oxygen sulfur; and the term "halo" refers to chloro, bromo, fluoro, and iodo.
Claim 3
Dependent Claim 33 words
A compound of claim 1 wherein: m is one or two; R 3 is hydrogen, lower alkyl, or aryl-(CH2) p -; p is zero or an integer from 1 to 6; and ##STR64##
Claim 4
Dependent Claim 11 words
The compound of claim 2, [4S-[4α, 7α, 13bβ]]-1,3,4,6,7,8,13,13b-octahydro-7-amino-6-oxo-2H-pyrido[1'2':1,2]azepino[3,4-b]indole-4-carboxylic acid, methyl acid.
Claim 5
Dependent Claim 9 words
The compound of claim 2, [5S-[5α,8α,11aβ]]-5,6,9,10,11,11a-hexahydro-7-amino-6-oxo-4H,8H-pyrido[1,2-a]thieno[3,2-c]azepine-8-carboxylic acid, methyl ester.
Claim 6
Dependent Claim 9 words
The compound of claim 2, [5S-[5α,8α,11aβ]]-5,6,9,10,11,11a-hexahydro-7-amino-6-oxo-4H,8H-pyrido[1,2-a]thieno[2,3-c]azepine-8-carboxylic acid, methyl ester.

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