Thiazine and thiazepine containing compounds

Claim 1

A compound of the formula ##STR197## and pharmaceutically acceptable salts thereof wherein: ##STR198## R 1 is hydrogen, lower alkyl, amino substituted lower alkyl, hydroxy substituted lower alkyl, or halo substituted lower alkyl; n is one or two; R 5 and R 6 are independently selected from the group consisting of hydrogen, lower alkyl, --(CH 2 ) m -cycloalkyl wherein said cycloalkyl is a saturated ring of 3 to 7 carbons, and ##STR199## m is zero or an integer from 1 to 4; R 14 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, halo, trifluoromethyl, or hydroxy; p is an integer from 1 to 3 provided that p is more than one only if R 14 is hydrogen, methyl, methoxy, chloro, or fluoro; R 7 is alkyl of 1 to 10 carbons, ##STR200## --(CH 2 ) s -cycloalkyl wherein cycloalkyl is a saturated ring of 3 to 7 carbons, --(CH 2 ) t --NH 2 ##STR201## s is zero or an integer from 1 to 7; t is an integer from 1 to 8; R 9 and R 12 are independently selected from the group consisting of lower alkyl, halo substituted lower alkyl-(CH 2 ) m -cycloalkyl wherein cycloalkyl is a saturated ring of 3 to 7 carbons, ##STR202## R 8 and R 2 are independently selected from the group consisting of hydrogen, lower alkyl, benzhydryl, an alkali metal ion, an alkaline earth metal ion, and ##STR203## R 10 is hydrogen, lower alkyl, cycloalkyl wherein cycloalkyl is a saturated ring of 3 to 7 carbons or phenyl; and R 11 is hydrogen, lower alkyl, lower alkoxy, cycloalkyl wherein cycloalkyl is a saturated ring of 3 to 7 carbons, phenyl, benzyl, or phenethyl.