US4824832A
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Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
Assignee: Aventis Inc
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Filing: 1987-12-30
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Granted: 1989-04-25
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Expires: 2007-12-30
Abstract
Abstract This invention relates to conformationally rigid sulfur containing tricyclic lactams, to the intermediates and processes useful for their preparation, and to their pharmacological effects in inhibiting angiotensin converting enzyme, in treating reperfusion injury and in treating heart-failure.
Inventors
- 👤 Gary A. Flynn
- 👤 Douglas W. Beight
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 16:48
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/55; A61P; A61P43/00; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P9/12
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
44 words
A compound of the formula ##STR5## wherein R is hydrogen, C 1 -C 6 lower alkyl, or (C 6 -C 12 )aryl(C 1 -C 6 )lower alkyl; and R' is hydrogen or --COR, wherein R is as defined above, or a pharmaceutically-acceptable salt thereof.
Claim 2
Dependent Claim
44 words
A compound of the formula ##STR5## wherein R is hydrogen, C 1 -C 6 lower alkyl, or (C 6 -C 12 )aryl(C 1 -C 6 )lower alkyl; and R' is hydrogen or --COR, wherein R is as defined above, or a pharmaceutically-acceptable salt thereof.
Claim 3
Dependent Claim
15 words
All enantiomeric isomers and diastereomeric isomers and mixtures thereof of a compound of claim 1.
Claim 4
Dependent Claim
17 words
A compound of claim 2 of the diastereomeric configuration: ##STR6## wherein the stereochemistry is 4(S), 7(S), 12b(R).
Claim 5
Dependent Claim
12 words
A compound of claim 3 wherein R and R' are both hydrogen.
Claim 6
Dependent Claim
13 words
A compound of claim 3 wherein R is methyl and R' is hydrogen.
Claim 7
Dependent Claim
26 words
A compound of the formula ##STR7## wherein R is C 1 -C 6 lower alkyl, or (C 6 -C 12 )aryl(C 1 -C 6 )lower alkyl.
Claim 8
Dependent Claim
26 words
A compound of the formula ##STR7## wherein R is C 1 -C 6 lower alkyl, or (C 6 -C 12 )aryl(C 1 -C 6 )lower alkyl.
Claim 9
Dependent Claim
27 words
A compound of the formula ##STR8## wherein R is hydrogen, C 1 -C 6 lower alkyl, or (C 6 -C 12 )aryl(C 1 -C 6 )lower alkyl.
Claim 10
Dependent Claim
27 words
A compound of the formula ##STR8## wherein R is hydrogen, C 1 -C 6 lower alkyl, or (C 6 -C 12 )aryl(C 1 -C 6 )lower alkyl.
Claim 11
Independent Claim
67 words
A method of treating hypertension which comprises administering to a patient in need thereof a compound of the formula ##STR9## wherein R is hydrogen, C 1 -C 6 lower alkyl, or (C 6 -C 12 )aryl(C 1 -C 6 )lower alkyl; and R' is hydrogen or --COR, wherein R is as defined above, or the pharmaceutically-acceptable salts thereof, in an amount necessary to effect an antihypertensive result.
Claim 12
Independent Claim
67 words
A method of treating hypertension which comprises administering to a patient in need thereof a compound of the formula ##STR9## wherein R is hydrogen, C 1 -C 6 lower alkyl, or (C 6 -C 12 )aryl(C 1 -C 6 )lower alkyl; and R' is hydrogen or --COR, wherein R is as defined above, or the pharmaceutically-acceptable salts thereof, in an amount necessary to effect an antihypertensive result.
Claim 13
Independent Claim
70 words
A method of treating cardiotonia which comprises administering to a patient in need thereof a compound of the formula ##STR10## wherein R is hydrogen, C 1 -C 6 lower alkyl, or (C 6 -C 12 )aryl(C 1 -C 6 )lower alkyl; and R' is hydrogen or --COR, wherein R is as defined above, or the pharmaceutically-acceptable salts thereof, in an amount necessary to effect an enhancement of myocardial contractile force.
Claim 14
Independent Claim
70 words
A method of treating cardiotonia which comprises administering to a patient in need thereof a compound of the formula ##STR10## wherein R is hydrogen, C 1 -C 6 lower alkyl, or (C 6 -C 12 )aryl(C 1 -C 6 )lower alkyl; and R' is hydrogen or --COR, wherein R is as defined above, or the pharmaceutically-acceptable salts thereof, in an amount necessary to effect an enhancement of myocardial contractile force.
Claim 15
Independent Claim
67 words
A method of treating ischemia which comprises administering to a patient in need thereof a compound of the formula ##STR11## wherein R is hydrogen, C 1 -C 6 lower alkyl, or (C 6 -C 12 )aryl(C 1 -C 6 )lower alkyl; and R' is hydrogen or --COR, wherein R is as defined above, or the pharmaceutically-acceptable salts thereof, in a quantity necessary to effect an anti-ischemic result.
Claim 16
Independent Claim
67 words
A method of treating ischemia which comprises administering to a patient in need thereof a compound of the formula ##STR11## wherein R is hydrogen, C 1 -C 6 lower alkyl, or (C 6 -C 12 )aryl(C 1 -C 6 )lower alkyl; and R' is hydrogen or --COR, wherein R is as defined above, or the pharmaceutically-acceptable salts thereof, in a quantity necessary to effect an anti-ischemic result.
References Cited (Backward Citations)
US3185680A
Cited
US4584294A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1992-04-24 | 1992-10-24 | 1993-04-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-04-24 | 1996-10-24 | 1997-04-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-04-24 | 2000-10-24 | 2001-04-25 | $7700.00 | Window Closed / Lapsed |