Compounds containing a fused bicycle ring and processes therefor

Claim 1

A compound of the formula ##STR87## or a pharmaceutically acceptable salt thereof wherein: A is ##STR88## X is O or S-(O) t ; R 1 and R 12 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, cycloalkyl, substituted alkyl, substituted alkenyl, aryl, substituted aryl, heteroaryl, cycloalkyl- alkylene-, aryl-alkylene-, substituted aryl- alkylene-, and heteroaryl-alkylene- or R 1 and R 12 taken together with the carbon to which they are attached complete a cycloalkyl ring or a benzolused cycloalkyl ring; R 2 is hydrogen, ##STR89## or R 11 -S-; R 3 , R 5 and R 7 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl- (CH 2 ) p-, substituted aryl- (CH 2 ) p -, heteroaryl-(CH 2 ) p - , ##STR90## R 4 is alkyl, cycloalkyl-(CH 2 ) p -, substituted alkyl, aryl-(CH 2 ) p -, substituted aryl-(CH 2 ) p -, or heteroaryl-(CH 2 ) p -; R 6 is alkyl, substituted alkyl, cycloalkyl-(CH 2 ) p -, aryl- (CH 2 ) p -, substituted aryl-(CH 2 ) p -, or heteroaryl-(CH 2 ) p -; R 8 is hydrogen, lower alkyl, cycloalkyl, or phenyl; R 9 is hydrogen, lower alkyl, lower alkoxy, or phenyl; R 10 is lower alkyl or aryl-(CH 2 ) p -; R 11 is hydrogen, alkyl, substituted alkyl, cycloalkyl-(CH 2 ) p -, aryl- (CH 2 ) p -, substituted aryl-(CH 2 ) p -, heteroaryl-(CH 2 ) p -, or -S-R 11 completes a symmetrical disulfide wherein R 11 is ##STR91## m is zero or one; Y is CH 2 , S-(O) t or O provided that Y is S-(O) t or O only when m is one; n is one or two; p is zero or an integer from 1 to 6; q is zero or an integer from 1 to 3; r is zero or one; and t is zero, one, or two.