US4722810A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Enkephalinase inhibitors
Assignee: ER Squibb and Sons LLC
•
Filing: 1986-08-13
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Granted: 1988-02-02
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Expires: 2006-08-13
Abstract
Abstract Mercaptoalkanoyl and acylmercaptoalkanoyl compounds of the formula ##STR1## wherein n is an integer from one to fifteen possess enkephalinase inhibition activity and are useful as analgesic agents.
Inventors
- 👤 Norma G. Delaney
- 👤 Eric M. Gordon
- 👤 Miguel A. Ondetti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 01:42
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/16
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
105 words
A compound of the formula ##STR91## including a pharmaceutically acceptable salt thereof wherein: R 1 is hydrogen; R 2 is ##STR92## R 3 is hydrogen, lower alkyl, ##STR93## n is an integer from 1 to 15; R 6 is lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, hydroxy, Cl, Br, F, or CF 3 ; r is an integer from 1 to 3 provided that r is more than one only if R 6 is hydroxy, methyl, methoxy, Cl or F; and m is zero or an integer from 1 to 4.
Claim 2
Dependent Claim
105 words
A compound of the formula ##STR91## including a pharmaceutically acceptable salt thereof wherein: R 1 is hydrogen; R 2 is ##STR92## R 3 is hydrogen, lower alkyl, ##STR93## n is an integer from 1 to 15; R 6 is lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, hydroxy, Cl, Br, F, or CF 3 ; r is an integer from 1 to 3 provided that r is more than one only if R 6 is hydroxy, methyl, methoxy, Cl or F; and m is zero or an integer from 1 to 4.
Claim 3
Dependent Claim
52 words
A compound of claim 1 wherein: R 1 is hydrogen; R 2 is ##STR94## R 3 is hydrogen, straight or branched chain alkyl of 1 to 4 carbons, ##STR95## m is one or two; R 6 is methyl, methoxy, Cl, F, or hydroxy; and n is an integer from 1 to 9.
Claim 4
Dependent Claim
22 words
The compound of claim 2 wherein: n is one; R 1 is hydrogen; R 2 is benzyl; and R 3 is benzyl.
Claim 5
Dependent Claim
19 words
A compound of claim 2 wherein: R 2 is benzyl; and n is an integer from 3 to 6.
Claim 6
Dependent Claim
19 words
A compound of claim 2 wherein: R 1 is hydrogen; R 3 is hydrogen; and R 2 is benzyl.
Claim 7
Dependent Claim
9 words
The compound of claim 5 wherein: n is one.
Claim 8
Dependent Claim
9 words
The compound of claim 5 wherein: n is 2.
Claim 9
Dependent Claim
9 words
The compound of claim 5 wherein: n is three.
Claim 10
Dependent Claim
9 words
The compound of claim 5 wherein: n is four.
Claim 11
Dependent Claim
9 words
The compound of claim 5 wherein: n is five.
Claim 12
Dependent Claim
9 words
The compound of claim 5 wherein: n is six.
Claim 13
Dependent Claim
9 words
The compound of claim 5 wherein: n is nine.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-02-01 | 1991-08-03 | 1992-02-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-02-01 | 1995-08-03 | 1996-02-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-02-01 | 1999-08-03 | 2000-02-02 | $7700.00 | Window Closed / Lapsed |