US4297275A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Inhibitors of mammalian collagenase
Assignee: ER Squibb and Sons LLC
•
Filing: 1980-02-14
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Granted: 1981-10-27
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Expires: 2000-02-14
Abstract
Abstract Mammalian collagenase is inhibited by compounds having the formula ##STR1## and salts thereof, wherein R 1 is hydrogen or alkanoyl of 2 to 10 carbon atoms; R 2 is hydroxy, amino, or ##STR2## R 3 is hydrogen, alkyl of 1 to 4 carbon atoms, ##STR3## R 4 is hydroxy, amino, arginine, leucine, glutamine, alanine or glycine; and m is 0 or an integer of 1 to 9.
Inventors
- 👤 Joseph E. Sundeen
- 👤 Tamara Dejneka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 22:19
CPC Classifications
C; C07; C07C; C07C327/00; C07C323/00; C07C51/00; C07C51/08; C07C51/347; C07C51/367; C07C51/377; C07C51/58; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
63 words
A compound having the formula ##STR30## or a salt thereof wherein R 1 is hydrogen or alkanoyl of 2 to 10 carbon atoms; R 2 is hydroxy, or ##STR31## R 3 is hydrogen, alkyl of 1 to 4 carbon atoms, ##STR32## R 4 is hydroxy, amino, arginine, leucine, glutamine, alanine or glycine; and m is 0 or an integer of 1 to 9.
Claim 2
Dependent Claim
63 words
A compound having the formula ##STR30## or a salt thereof wherein R 1 is hydrogen or alkanoyl of 2 to 10 carbon atoms; R 2 is hydroxy, or ##STR31## R 3 is hydrogen, alkyl of 1 to 4 carbon atoms, ##STR32## R 4 is hydroxy, amino, arginine, leucine, glutamine, alanine or glycine; and m is 0 or an integer of 1 to 9.
Claim 3
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 1 is hydrogen.
Claim 4
Dependent Claim
18 words
A compound in accordance with claim 1 wherein R 1 is alkanoyl of 2 to 10 carbon atoms.
Claim 5
Dependent Claim
12 words
A compound in accordance with claim 2 wherein R 2 is hydroxy.
Claim 6
Dependent Claim
12 words
A compound in accordance with claim 2 wherein R 2 is ##STR33##
Claim 7
Dependent Claim
11 words
A compound in accordance with claim 5 wherein m is 0.
Claim 8
Dependent Claim
16 words
A compound in accordance with claim 5 wherein m is an integer of 1 to 9.
Claim 9
Dependent Claim
12 words
A compound in accordance with claim 2 wherein R 3 is hydrogen.
Claim 10
Dependent Claim
18 words
A compound in accordance with claim 2 wherein R 3 is alkyl of 1 to 4 carbon atoms.
Claim 11
Dependent Claim
12 words
A compound in accordance with claim 2 wherein R 3 is ##STR34##
Claim 12
Dependent Claim
12 words
A compound in accordance with claim 2 wherein R 3 is ##STR35##
Claim 13
Dependent Claim
12 words
A compound in accordance with claim 2 wherein R 4 is hydroxy.
Claim 14
Dependent Claim
12 words
A compound in accordance with claim 2 wherein R 4 is amino.
Claim 15
Dependent Claim
17 words
A compound in accordance with claim 2 wherein R 4 is arginine, leucine, glutamine, alanine or glycine.
Claim 16
Dependent Claim
11 words
The compound in accordance with claim 1, 2-(mercaptomethyl)-4-methylpentanoic acid, ammonium salt.
Claim 17
Dependent Claim
8 words
The compound in accordance with claim 1, N-[2-(mercaptomethyl)-4-methyl-1-oxopentyl]glycine.
Claim 18
Dependent Claim
8 words
The compound in accordance with claim 1, N-[6-[2-[(acetylthio)methyl]-4-methyl-1-oxopentyl]-1-oxohexyl]-L-arginine.
Claim 19
Dependent Claim
8 words
The compound in accordance with claim 1, N-[6-[[2-(mercaptomethyl)-4-methyl-1-oxopentyl]amino]-1-oxohexyl]-L-arginine.
Claim 20
Dependent Claim
8 words
The compound in accordance with claim 1, 6-[[2-[(acetylthio)methyl]-4-methyl-1-oxopentyl]amino]hexanamide.
Claim 21
Dependent Claim
8 words
The compound in accordance with claim 1, N-[N-[2-(mercaptomethyl)-4-methyl-1-oxopentyl]glycyl]-L-arginine.
Claim 22
Dependent Claim
8 words
The compound in accordance with claim 1, N-[5-[[2-(mercaptomethyl)-4-methyl-1-oxopentyl]amino-1-oxopentyl]-L-arginine.
Claim 23
Dependent Claim
8 words
The compound in accordance with claim 1, N-[8-[[2-(mercaptomethyl)-4-methyl-1-oxopentyl]amino-1-oxooctyl]-L-arginine.
References Cited (Backward Citations)
US4146611A
Cited
US4179434A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-10-26 | 1985-04-27 | 1985-10-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-10-26 | 1989-04-27 | 1989-10-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-10-26 | 1993-04-27 | 1993-10-27 | $7700.00 | Window Closed / Lapsed |