Mercaptoacyl aminolactam endopeptidase inhibitors

Claim 1

A compound represented by the formula ##STR49## wherein Y is -(CHR 5 ) n -(CR 3 R 4 )- or -(CR 3 R 4 ) p X(CR 3 R 4 ) q -, wherein two substituents selected from the group consisting of R 3 , R 4 and R 5 , together with the carbons to which the substituents are attached, when the substituents are present on adjacent carbon atoms, can form a benzene, cyclopentane or cyclohexane ring; X is -O-, -S-, -SO- or -SO 2 -; Q is hydrogen or R 6 CO-; m is 1 or 2; n is 1, 2, 3 or 4; p is 1 or 2; q is 2 or 3; R 1 is lower alkyl; aryl, selected from the group consisting of phenyl, naphthyl, substituted phenyl and substituted naphthyl, wherein said substituted phenyl and substituted naphthyl groups are substituted with 1-3 substituents selected from the group consisting of lower alkyl, hydroxy, lower alkoxy, halo, trifluoromethyl, phenyl, phenoxy and phenylthio; heteroaryl or substituted heteroaryl, wherein heteroaryl is selected from the group consisting of furanyl, thienyl, pyrrolyl and pyridyl, and wherein said substituted heteroaryl is substituted with 1-3 substituents selected from the group consisting of lower alkyl, hydroxy, lower alkoxy, halo, trifluoromethyl, phenyl, phenoxy and phenylthio; R 2 is hydrogen, lower alkyl, hydroxylower alkyl, loweralkoxylower alkyl, aryllower alkyl, heteroaryllower alkyl, substituted-aryllower alkyl, or substituted-heteroaryllower alkyl, wherein aryl, heteroaryl, substituted aryl and substituted heteraryl are as defined above; R 3 and R 4 are independently hydrogen, lower alkyl, aryllower alkyl, heteroaryllower alkyl, substituted-aryllower alkyl, or substituted-heteroaryllower alkyl, wherein aryl, heteroaryl, substituted aryl and substituted heteroaryl are as defined above; R 5 is hydrogen, lower alkyl, aryllower alkyl, heteroaryllower alkyl, hydroxy, lower alkoxy, mercapto, lower alkylthio, substituted-aryllower alkyl, or substituted-heteroaryllower alkyl, wherein aryl, heteroaryl, substituted aryl and substituted heteroaryl are as defined above; and R 6 is lower alkyl, aryl, heteroaryl, wherein aryl, heteroaryl, substituted aryl and substituted heteroaryl are as defined above.