US4508729A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
Assignee: Institut Servier de Medecine Translationnelle SARL
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Filing: 1981-10-02
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Granted: 1985-04-02
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Expires: 2001-10-02
Abstract
Abstract Compounds of the general formula: <IMAGE> wherein: the ring A is saturated and n=0 or 1, or the ring A is a benzene ring and n=1, R1 represents a lower alkyl group which can carry an amino group, R2 represents a hydrogen atom or a lower alkyl group, R3 represents a straight or branched alkyl group, a mono- or di-cycloalkylalkyl or phenylalkyl group having no more than a total of 9 carbon atoms, or a substituted alkyl group, and also the salts thereof. These compounds are useful as therapeutic drugs.
Inventors
- 👤 Michel Vincent
- 👤 Georges Remond
- 👤 Michel Laubie
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 14:11
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06008; C07K5/06017; C07K5/06026; C07D; C07D209/00; C07D209/02; C07D209/44; C07D217/00; C07D217/22; C07D217/26; C07D339/00; C07D339/08; C07K5/02; C07K5/022; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
79 words
A compound selected from the group consisting of iminodiacid compounds having the formula: ##STR20## wherein R 1 represents lower-alkyl having 1 to 4 carbon atoms, inclusive, R 2 represents hydrogen or lower-alkyl having 1 to 4 carbon atoms, inclusive, R 3 is --CH 2 CH 2 --CH 3 , in racemic form or as an optical isomer, a salt thereof with a pharmaceutically-acceptable inorganic or organic base, and an addition salt thereof with a pharmaceutically-acceptable inorganic or organic acid.
Claim 2
Dependent Claim
79 words
A compound selected from the group consisting of iminodiacid compounds having the formula: ##STR20## wherein R 1 represents lower-alkyl having 1 to 4 carbon atoms, inclusive, R 2 represents hydrogen or lower-alkyl having 1 to 4 carbon atoms, inclusive, R 3 is --CH 2 CH 2 --CH 3 , in racemic form or as an optical isomer, a salt thereof with a pharmaceutically-acceptable inorganic or organic base, and an addition salt thereof with a pharmaceutically-acceptable inorganic or organic acid.
Claim 3
Dependent Claim
13 words
A compound of claim 1, in which R 1 is a methyl radical.
Claim 4
Dependent Claim
9 words
(2S)-1-{N[(1RS)-1-ethoxycarbonylbutyl]-(S)-alanyl}-2-carboxyperhydroindole, its (S)-isomer or the sodium salt of these.
Claim 5
Dependent Claim
9 words
(2S)-1-{N[(1RS)-1-ethoxycarbonylbutyl]-(S)-alanyl}-2-carboxyperhydroindole, its (S)-isomer or the sodium salt of these.
Claim 6
Dependent Claim
25 words
A pharmaceutical composition containing as active ingredient at least one compound according to claim 1, in conjunction with an inert, non-toxic pharmaceutically-acceptable carrier or excipient.
Claim 7
Dependent Claim
23 words
A pharmaceutical composition containing as active ingredient a compound according to claim 3, in conjunction with an inert, non-toxic pharmaceutically-acceptable carrier or excipient.
Claim 8
Dependent Claim
26 words
A method for treating a patient suffering from hypertension, which comprises administering to said patient a therapeutically effective dose of a compound according to claim 1.
Claim 9
Dependent Claim
25 words
A method for treating a patient suffering from hypertension, which comprises administering to said patient a therapeutically-effective dose of a compound according to claim 3.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-04-01 | 1988-10-01 | 1989-04-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-04-01 | 1992-10-01 | 1993-04-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-04-01 | 1996-10-01 | 1997-04-02 | $7700.00 | Window Closed / Lapsed |