US4740499A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of enhancing the bioactivity of atrial peptides
Assignee: Monsanto Co
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Filing: 1986-07-28
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Granted: 1988-04-26
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Expires: 2006-07-28
Abstract
Abstract A method of prolonging or enhancing the bioactivity of atrial peptides is disclosed in which thiorphan or kelatorphan is administered contemporaneously with the administration of the atrial peptide.
Inventors
- 👤 Gillian M. Olins
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 20:44
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/2242; A61K31/00; A61K31/185; A61K31/19; A61K31/195
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
30 words
The method of prolonging or enhancing the bioactivity of an atrial peptide administered to a mammal comprising substantially contemporaneously administering to said mammal an effective amount of thiorphan or kelatorphan.
Claim 2
Independent Claim
30 words
The method of prolonging or enhancing the bioactivity of an atrial peptide administered to a mammal comprising substantially contemporaneously administering to said mammal an effective amount of thiorphan or kelatorphan.
Claim 3
Dependent Claim
45 words
The method of claim 1 in which the atrial peptide has the following amino acid sequence ##STR5## wherein R 1 =H; ser; ser-ser; arg-ser-ser; arg-arg-ser-ser; leu-arg-arg-ser-ser; ser-leu-arg-arg-ser-ser; R 2 =OH; ser; ser-phe; ser-phe-arg; ser-phe-arg-tyr; X=ile; met; or the physiologically acceptable salts, esters or amides thereof.
Claim 4
Dependent Claim
17 words
The method of claim 1 in which the atrial peptide has the following amino acid sequence ##STR6##
Claim 5
Dependent Claim
14 words
The method of claim 1 in which the atrial peptide is administered with thiorphan.
Claim 6
Dependent Claim
14 words
The method of claim 1 in which the atrial peptide is administered with kelatorphan.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-04-26 | 1991-10-26 | 1992-04-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-04-26 | 1995-10-26 | 1996-04-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-04-26 | 1999-10-26 | 2000-04-26 | $7700.00 | Window Closed / Lapsed |