Mercapto-acylamino acids as antihypertensives

Claim 1

A compound having the structural formula ##STR63## wherein R 1 is H or R 5 CO--; R 2 is Y--C 6 H 4 --, Y--C 6 H 4 S--, Y--C 6 H 4 O--, Y--C 6 H 4 CH 2 S--, Y--C 6 H 4 CH 2 O--, α-naphthyl, β-naphthyl, β-naphthyl, diphenylmethyl or ##STR64## R 3 is --OR 6 , --NR 6 R 7 or ##STR65## R 4 is hydrogen, lower alkyl or aryl lower alkyl; R 5 is lower alkyl, hydroxylower alkyl, lower alkoxy lower alkyl; (di-lower alkyl) amino lower alkyl, Y 1 --C 6 H 4 --lower alkyl, lower alkoxy, Y 1 --C 6 H 4 --, naphthyl; R 6 and R 7 are independently hydrogen, lower alkyl or substituted lower alkyl wherein the substituents are selected from the group consisting of 1 or 2 hydroxy groups, 1 or 2 lower alkoxy groups, lower alkoxy lower alkoxy, halogeno, halogeno lower alkoxy, amino, mono- or di-lower alkylamino, aryl, or substituted aryl wherein the substituents on aryl are 1-3 substituents selected from the group consisting of lower alkyl, hydroxy, halogeno, lower alkoxy and amino; R 8 is hydrogen, alkyl, carboxyalkyl, mercaptoalkyl, alkylthioalkyl, aminoalkyl, hydroxyalkyl, phenylalkyl, hydroxyphenylalkyl, guanidinoalkyl, or carbamoylalkyl; n is 0-3; A is ##STR66## X and X 1 are independently a bond, --O--, --S--, or --CH 2 --; Y, Y 1 and Y 2 are independently 1 to 3 substituents selected from the group consisting of hydrogen, lower alkyl, cyclolower alkyl, lower alkoxy, OH, F, Cl, Br, I, --CN, --CO 2 H, --CO 2 --lower alkyl, --CH 2 NH 2 , --CONH 2 and aryl; wherein aryl means mono-cyclic or fused ring bicyclic aromatic groups having 6 to 10 ring members or a pharmaceutically acceptable acid addition salt thereof.