US4005222A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Mucolytic mercaptoacylamidobenzoic and benzenesulfonic acid compounds and process
Assignee: Mead Johnson and Co LLC
•
Filing: 1975-05-21
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Granted: 1977-01-25
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Expires: 1995-05-21
Abstract
Abstract A mucolytic process is disclosed which comprises contacting N-(2-hydroxyethyl)mercaptoacetamidobenzamides or mercaptoacylamidobenzoic acids, mercaptoacetylsulfanilic acids and alkanoylthio derivatives thereof with mucus. Illustrative of compounds useful in the mucolytic process of the present invention are 4-(2-mercaptoacetamido)benzoic acid and N-(2-mercaptoacetyl)sulfanilic acid.
Inventors
- 👤 Tellis Alexander Martin
- 👤 William Timmey Comer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 08:43
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/16; A61K31/165; A61K31/185; A61K31/19; A61K31/195; A61K31/21; A61K31/265; A61P; A61P11/00; A61P11/10; A61P13/00; A61P13/02; A61P15/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
74 words
A process for liquiefaction of mucus which comprises contacting said mucus with a mucolytically effective amount of a member selected from the group consisting of compounds having Formula I ##STR6## wherein A is meta or para CO 2 H; Alk is a straight or branched divalent alkylene radical of from 1 to 3 carbon atoms inclusive; R is hydrogen or alkanoyl having up to 18 carbon atoms inclusive; and a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
74 words
A process for liquiefaction of mucus which comprises contacting said mucus with a mucolytically effective amount of a member selected from the group consisting of compounds having Formula I ##STR6## wherein A is meta or para CO 2 H; Alk is a straight or branched divalent alkylene radical of from 1 to 3 carbon atoms inclusive; R is hydrogen or alkanoyl having up to 18 carbon atoms inclusive; and a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
21 words
The process as claimed in claim 1 wherein said contacting step is carried out within the respiratory tract of a mammal.
Claim 4
Dependent Claim
16 words
The process as claimed in claim 1 wherein said contacting step is carried out in vitro.
Claim 5
Dependent Claim
30 words
The process as claimed in claim 1 wherein said mucus is contacted with about 0.003 to 0.5 molar solution of said compound for a time sufficient to liquify said mucus.
Claim 6
Dependent Claim
16 words
The process as claimed in claim 4 wherein said time is from 1 to 15 minutes.
Claim 7
Dependent Claim
13 words
The process as claimed in claim 1 wherein said compound is 4-(2-mercaptoacetamido)benzoic acid.
Claim 8
Dependent Claim
13 words
The process as claimed in claim 1 wherein said compound is 3-(2-mercaptoacetamido)benzoic acid.
Claim 9
Dependent Claim
13 words
The process as claimed in claim 1 wherein said compound is 4-[2-(acetylthio)acetamido]benzoic acid.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-01-25 | 1980-07-26 | 1981-01-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-01-25 | 1984-07-26 | 1985-01-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-01-25 | 1988-07-26 | 1989-01-25 | $7700.00 | Window Closed / Lapsed |