Bicyclic derivatives of 1, 4- dihydropyridine
Abstract
Abstract 1,4-Dihydropyridines bearing carbonyl functions in the 3- and 5positions, being optionally substituted by lower alkyl in the 6position, being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group, and being fused through the 1- and 2-positions to a five, six or seven membered cycloalkyl ring, one methylene group of which can be replaced by sulfur, oxygen imino or alkylimino, are antihypertensive agents and coronary vessel dilators. The compounds, of which 6-methyl-4-(3-nitrophenyl)-1,2pentamethylene-1,4-dihydropyridine-3,5 -dicarboxylic acid 3,5diethyl ester is a representative embodiment, are prepared through condensation of an ylideneacetoacetic acid ester and a cyclic enamino carbonyl derivative.
Inventors
- 👤 H Meyer
- 👤 K Stoepel
- 👤 F Bossert
- 👤 W Vater
Bibliographic Details
Claims Analysis
Total Claims: 17References Cited (Backward Citations)
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